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Article: Comparison of tamoxifen with danazol in the management of idiopathic gynecomastia

TitleComparison of tamoxifen with danazol in the management of idiopathic gynecomastia
Authors
Issue Date2000
PublisherSoutheastern Surgical Congress. The Journal's web site is located at http://www.sesc.org/TAS/Journal.htm
Citation
American Surgeon, 2000, v. 66 n. 1, p. 38-40 How to Cite?
AbstractIdiopathic gynecomastia, unilateral or bilateral, is a common physical finding in normal men. Successful treatment using tamoxifen (antiestrogen) and danazol (antiandrogen) has recently been reported. We compared the efficacy of tamoxifen and danazol in the treatment of idiopathic gynecomastia. We reviewed the clinical records of patients with idiopathic gynecomastia presenting to the Department of Surgery, University of Hong Kong, between August 1990 and September 1995. Medical treatment with either tamoxifen (20 mg/d) or danazol (400 mg/d) was offered and continued until a static response was achieved. The treatment response was compared. Sixty-eight patients with idiopathic gynecomastia were seen in the Breast Clinic. The median age was 39.5 years (range, 13-82), with a median duration of symptoms of 3 months (range, 1-90). The median size was 3 cm (range, 1-7). Twenty-three patients were treated with tamoxifen and 20 with danazol. Complete resolution of the gynecomastia was recorded in 18 patients (78.2%) treated with tamoxifen, whereas only 8 patients (40%) in the danazol group had complete resolution. Five patients, all from the tamoxifen group, developed recurrence of breast mass. In conclusion, hormonal manipulation is effective in the treatment of patients with idiopathic gynecomastia. Although the effect is more marked for tamoxifen compared with danazol, the relapse rate is higher for tamoxifen. Further prospective randomized studies would be useful in defining the role of these drugs in the management of patients with idiopathic gynecomastia.
Persistent Identifierhttp://hdl.handle.net/10722/225925
ISSN
2015 Impact Factor: 0.769
2015 SCImago Journal Rankings: 0.464

 

DC FieldValueLanguage
dc.contributor.authorTing, ACW-
dc.contributor.authorChow, LWC-
dc.contributor.authorLeung, YF-
dc.date.accessioned2016-05-25T03:41:43Z-
dc.date.available2016-05-25T03:41:43Z-
dc.date.issued2000-
dc.identifier.citationAmerican Surgeon, 2000, v. 66 n. 1, p. 38-40-
dc.identifier.issn0003-1348-
dc.identifier.urihttp://hdl.handle.net/10722/225925-
dc.description.abstractIdiopathic gynecomastia, unilateral or bilateral, is a common physical finding in normal men. Successful treatment using tamoxifen (antiestrogen) and danazol (antiandrogen) has recently been reported. We compared the efficacy of tamoxifen and danazol in the treatment of idiopathic gynecomastia. We reviewed the clinical records of patients with idiopathic gynecomastia presenting to the Department of Surgery, University of Hong Kong, between August 1990 and September 1995. Medical treatment with either tamoxifen (20 mg/d) or danazol (400 mg/d) was offered and continued until a static response was achieved. The treatment response was compared. Sixty-eight patients with idiopathic gynecomastia were seen in the Breast Clinic. The median age was 39.5 years (range, 13-82), with a median duration of symptoms of 3 months (range, 1-90). The median size was 3 cm (range, 1-7). Twenty-three patients were treated with tamoxifen and 20 with danazol. Complete resolution of the gynecomastia was recorded in 18 patients (78.2%) treated with tamoxifen, whereas only 8 patients (40%) in the danazol group had complete resolution. Five patients, all from the tamoxifen group, developed recurrence of breast mass. In conclusion, hormonal manipulation is effective in the treatment of patients with idiopathic gynecomastia. Although the effect is more marked for tamoxifen compared with danazol, the relapse rate is higher for tamoxifen. Further prospective randomized studies would be useful in defining the role of these drugs in the management of patients with idiopathic gynecomastia.-
dc.languageeng-
dc.publisherSoutheastern Surgical Congress. The Journal's web site is located at http://www.sesc.org/TAS/Journal.htm-
dc.relation.ispartofAmerican Surgeon-
dc.subject.meshAged, 80 and over-
dc.subject.meshDanazol - therapeutic use-
dc.subject.meshEstrogen Antagonists - therapeutic use-
dc.subject.meshGynecomastia - drug therapy-
dc.subject.meshTamoxifen - therapeutic use-
dc.titleComparison of tamoxifen with danazol in the management of idiopathic gynecomastia-
dc.typeArticle-
dc.identifier.emailTing, ACW: tingacw@hkucc.hku.hk-
dc.identifier.emailChow, LWC: lwcchow@hkucc.hku.hk-
dc.identifier.pmid10651345-
dc.identifier.hkuros47842-
dc.identifier.volume66-
dc.identifier.issue1-
dc.identifier.spage38-
dc.identifier.epage40-
dc.publisher.placeUnited States-

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