File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Cytokine production by human lymphocytes stimulated by a herbal compound containing Bupleurum (KY88 LIVER LIVO)

TitleCytokine production by human lymphocytes stimulated by a herbal compound containing Bupleurum (KY88 LIVER LIVO)
Authors
KeywordsBupleurum
KY88 LIVER LIVO
Chinese traditional medicine
Lymphocyte proliferation
Interleukins
Issue Date2003
PublisherChinese Pharmacological Society and Shanghai Institute of Materia Medica, Chinese Academy of Sciences. The Journal's web site is located at http://www.chinaphar.com/1671-4083/online.htm
Citation
Acta Pharmacologica Sinica, 2003, v. 24 n. 2, p. 140-144 How to Cite?
中國藥理學報 (英文版), 2003, v. 24 n. 2, p. 140-144 How to Cite?
AbstractAIM: Compounds containing Bupleurum possess immunomodulating effects. KY88 LIVER LIVO (KY88) is a blend of such compound. The aim of this study is to investigate the effects of KY88 on the production of cytokines by lymphocytes in vitro. METHODS: Seventy Sprague Dawley rats were used of which 40 were orally fed with 4 mg purified KY88 for 35 d. Normal human lymphocytes were isolated and cultured in standard conditions. The culture medium was collected at zero and 72 h after the KY88 treatment. The cytokines, including interleukin-1 (IL-1), IL-2, IL-4, IL-6, tumor necrosis factor- (TNF-), and interferon-, were measured by ELISA kits. RESULTS: TNF- levels in the supernatant of cultured human lymphocytes significantly increased after the treatment of PHA and KY88. The mean levels were (855±251), (399±145), and (176±49) ng/L after the treatment with KY88 at the concentrations of 10, 1 and 0.1 g/mL respectively. However, the level in the control group without specific treatment was only (68±4) ng/L. The difference between KY88 10 g/mL and control groups was significant (P<0.05). All other cytokines did not show significant variations between KY88 and the control groups. KY88 may regulate the immune function through the induction of TNF- expression.
Persistent Identifierhttp://hdl.handle.net/10722/225482
ISSN
2015 Impact Factor: 3.166
2015 SCImago Journal Rankings: 1.161

 

DC FieldValueLanguage
dc.contributor.authorChow, WCL-
dc.contributor.authorLoo, TY-
dc.contributor.authorSham, STJ-
dc.date.accessioned2016-05-18T01:45:15Z-
dc.date.available2016-05-18T01:45:15Z-
dc.date.issued2003-
dc.identifier.citationActa Pharmacologica Sinica, 2003, v. 24 n. 2, p. 140-144-
dc.identifier.citation中國藥理學報 (英文版), 2003, v. 24 n. 2, p. 140-144-
dc.identifier.issn1671-4083-
dc.identifier.urihttp://hdl.handle.net/10722/225482-
dc.description.abstractAIM: Compounds containing Bupleurum possess immunomodulating effects. KY88 LIVER LIVO (KY88) is a blend of such compound. The aim of this study is to investigate the effects of KY88 on the production of cytokines by lymphocytes in vitro. METHODS: Seventy Sprague Dawley rats were used of which 40 were orally fed with 4 mg purified KY88 for 35 d. Normal human lymphocytes were isolated and cultured in standard conditions. The culture medium was collected at zero and 72 h after the KY88 treatment. The cytokines, including interleukin-1 (IL-1), IL-2, IL-4, IL-6, tumor necrosis factor- (TNF-), and interferon-, were measured by ELISA kits. RESULTS: TNF- levels in the supernatant of cultured human lymphocytes significantly increased after the treatment of PHA and KY88. The mean levels were (855±251), (399±145), and (176±49) ng/L after the treatment with KY88 at the concentrations of 10, 1 and 0.1 g/mL respectively. However, the level in the control group without specific treatment was only (68±4) ng/L. The difference between KY88 10 g/mL and control groups was significant (P<0.05). All other cytokines did not show significant variations between KY88 and the control groups. KY88 may regulate the immune function through the induction of TNF- expression.-
dc.languageeng-
dc.publisherChinese Pharmacological Society and Shanghai Institute of Materia Medica, Chinese Academy of Sciences. The Journal's web site is located at http://www.chinaphar.com/1671-4083/online.htm-
dc.relation.ispartofActa Pharmacologica Sinica-
dc.relation.ispartof中國藥理學報 (英文版)-
dc.subjectBupleurum-
dc.subjectKY88 LIVER LIVO-
dc.subjectChinese traditional medicine-
dc.subjectLymphocyte proliferation-
dc.subjectInterleukins-
dc.titleCytokine production by human lymphocytes stimulated by a herbal compound containing Bupleurum (KY88 LIVER LIVO)-
dc.typeArticle-
dc.identifier.emailChow, WCL: lwcchow@hkucc.hku.hk-
dc.identifier.emailLoo, TY: tyloo@hkucc.hku.hk-
dc.identifier.emailSham, STJ: jstsham@hku.hk-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.pmid12546721-
dc.identifier.hkuros75762-
dc.identifier.volume24-
dc.identifier.issue2-
dc.identifier.spage140-
dc.identifier.epage144-
dc.publisher.placeChina-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats