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Article: Capacitative Ca2+ entry in HL-60 cells: tetrandrine and SK & F 96365 as probes

TitleCapacitative Ca2+ entry in HL-60 cells: tetrandrine and SK & F 96365 as probes
白血病HL-60細胞的電容性鈣內流:粉防己堿與SK&F96365作為探測藥
Authors
Issue Date1996
PublisherScience Press (科學出版社). The Journal's web site is located at http://www.chinaphar.com/
Citation
Acta Pharmacologica Sinica, 1996, v. 17 n. 2, p. 97-101 How to Cite?
中國藥理學報 (英文版), 1996, v. 17 n. 2, p. 97-101 How to Cite?
AbstractAgonist-activated Ca2+ entry is important in many biological responses such as secretion and cell growth(1,2). In nonexcitable cells which have no voltage-operated Ca2+ channels (VOCC), agonist-receptor interaction can trigger Ca2+ entry across the plasmalemma via several entry pathways(1-3) (Fig 1): (A) channels which are intrinsic structures of the receptor (receptor-operated channels), (B) channels which are coupled to receptors via a G-protein (G-protein-operated channels), (C) channels which are activated by some second messengers (second-messenger-operated channels), and (D) channels which open upon intracellular nonmitochondrial Ca2+ store depletion (Ca2+ release-activated channels) resulting from inositol 1, 4, 5-trisphosphate-induced Ca2+ release or inhibition of Ca2+ re-uptake (see next section). Ca2+ entry via the 4th type of channel, also known as 'capacitative Ca2+ entry' (CCE)[4], has aroused much interest in the past decade because of its intriguing nature as retrograde signalling. In this brief review, we present the evidence for and the possible biochemical processes involved in CCE. We also discuss the use of 2 novel Ca2+ entry blockers: tetrandrine and SK&F 96365. Emphasis will be put on the human leukemic HL-60 cell line, a popular cell system for intracellular Ca2+ homeostasis studies and also a model the signal transduction of which we have been investigating during the past few years.
Persistent Identifierhttp://hdl.handle.net/10722/225465
ISSN
2000 Impact Factor: 0.485

 

DC FieldValueLanguage
dc.contributor.authorLeung, YM-
dc.contributor.authorKwan, CY-
dc.contributor.authorLoh, TT-
dc.date.accessioned2016-05-17T07:38:03Z-
dc.date.available2016-05-17T07:38:03Z-
dc.date.issued1996-
dc.identifier.citationActa Pharmacologica Sinica, 1996, v. 17 n. 2, p. 97-101-
dc.identifier.citation中國藥理學報 (英文版), 1996, v. 17 n. 2, p. 97-101-
dc.identifier.issn0253-9756-
dc.identifier.urihttp://hdl.handle.net/10722/225465-
dc.description.abstractAgonist-activated Ca2+ entry is important in many biological responses such as secretion and cell growth(1,2). In nonexcitable cells which have no voltage-operated Ca2+ channels (VOCC), agonist-receptor interaction can trigger Ca2+ entry across the plasmalemma via several entry pathways(1-3) (Fig 1): (A) channels which are intrinsic structures of the receptor (receptor-operated channels), (B) channels which are coupled to receptors via a G-protein (G-protein-operated channels), (C) channels which are activated by some second messengers (second-messenger-operated channels), and (D) channels which open upon intracellular nonmitochondrial Ca2+ store depletion (Ca2+ release-activated channels) resulting from inositol 1, 4, 5-trisphosphate-induced Ca2+ release or inhibition of Ca2+ re-uptake (see next section). Ca2+ entry via the 4th type of channel, also known as 'capacitative Ca2+ entry' (CCE)[4], has aroused much interest in the past decade because of its intriguing nature as retrograde signalling. In this brief review, we present the evidence for and the possible biochemical processes involved in CCE. We also discuss the use of 2 novel Ca2+ entry blockers: tetrandrine and SK&F 96365. Emphasis will be put on the human leukemic HL-60 cell line, a popular cell system for intracellular Ca2+ homeostasis studies and also a model the signal transduction of which we have been investigating during the past few years.-
dc.languageeng-
dc.publisherScience Press (科學出版社). The Journal's web site is located at http://www.chinaphar.com/-
dc.relation.ispartofActa Pharmacologica Sinica-
dc.relation.ispartof中國藥理學報 (英文版)-
dc.subject.meshAlkaloids - pharmacology-
dc.subject.meshBenzylisoquinolines-
dc.subject.meshCalcium - metabolism-
dc.subject.meshCalcium Channel Blockers - pharmacology-
dc.subject.meshImidazoles - pharmacology-
dc.titleCapacitative Ca2+ entry in HL-60 cells: tetrandrine and SK & F 96365 as probes-
dc.title白血病HL-60細胞的電容性鈣內流:粉防己堿與SK&F96365作為探測藥-
dc.typeArticle-
dc.identifier.emailKwan, CY: cykwan@hkucc.hku.hk-
dc.identifier.emailLoh, TT: ttloh@hkucc.hku.hk-
dc.identifier.pmid9772652-
dc.identifier.hkuros11275-
dc.identifier.volume17-
dc.identifier.issue2-
dc.identifier.spage97-
dc.identifier.epage101-
dc.publisher.placeBeijing (北京)-

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