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  Patent History
  • Application
    EP 20110795024 2011-06-15
  • Granted
    EP 2582410 2013-04-24

granted patent: METHODS FOR COMPLEX TISSUE ENGINEERING

TitleMETHODS FOR COMPLEX TISSUE ENGINEERING
Granted PatentEP 2582410
Granted Date2013-04-24
Priority Date2010-06-15 US 12/354869P
2011-06-15 PCT/CN2011000988
Inventors
Issue Date2013
Citation
EP Patent EP 2582410. European Patent Office (EPO), Escapenet, 2013 How to Cite?
AbstractA simple, highly flexible and scalable platform for making functional complex tissue with heterogeneity and irregularity is provided. The method includes combining undifferentiated cells, such as pluripotent or multipotent stem cells, with a biomaterial to make multiple undifferentiated or naive subunits, exposing the undifferentiated or naive subunits to different cell culture environments for induction of differentiation towards different lineages as required by said complex tissue, and combining the then functional subunits solely or with the undifferentiated subunits. The differentiated subunits thus combined can be cultured under biological, chemical, and/or physical culture conditions suitable to fine-tune the structural and functional properties of the bioengineered complex tissue to form a bioengineered tissue graft that mimics the structural and functional characteristics of native complex tissue. Said bioengineered tissue graft can be used to replace dysfunctional tissue.
Persistent Identifierhttp://hdl.handle.net/10722/225267
References

 

DC FieldValueLanguage
dc.date.accessioned2016-05-03T05:10:11Z-
dc.date.available2016-05-03T05:10:11Z-
dc.date.issued2013-
dc.identifier.citationEP Patent EP 2582410. European Patent Office (EPO), Escapenet, 2013-
dc.identifier.urihttp://hdl.handle.net/10722/225267-
dc.description.abstractA simple, highly flexible and scalable platform for making functional complex tissue with heterogeneity and irregularity is provided. The method includes combining undifferentiated cells, such as pluripotent or multipotent stem cells, with a biomaterial to make multiple undifferentiated or naive subunits, exposing the undifferentiated or naive subunits to different cell culture environments for induction of differentiation towards different lineages as required by said complex tissue, and combining the then functional subunits solely or with the undifferentiated subunits. The differentiated subunits thus combined can be cultured under biological, chemical, and/or physical culture conditions suitable to fine-tune the structural and functional properties of the bioengineered complex tissue to form a bioengineered tissue graft that mimics the structural and functional characteristics of native complex tissue. Said bioengineered tissue graft can be used to replace dysfunctional tissue.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License for public patent documents-
dc.titleMETHODS FOR COMPLEX TISSUE ENGINEERING-
dc.typePatent-
dc.identifier.authorityCHAN, PUI BARBARA=rp00087-
dc.identifier.authorityCHEUNG, MANCHEE KENNETH=rp00387-
dc.identifier.authorityLUK, DIPKEI KEITH=rp00333-
dc.description.naturepublished_or_final_version-
dc.contributor.inventorCHAN, PUI BARBARA-
dc.contributor.inventorCHENG, HIUWA-
dc.contributor.inventorCHIK, TSZKIT DANIEL-
dc.contributor.inventorCHEUNG, MANCHEE KENNETH-
dc.contributor.inventorLUK, DIPKEI KEITH-
patents.identifier.applicationEP 20110795024-
patents.identifier.grantedEP 2582410-
patents.description.assignee UNIV HONG KONG [CN] -
patents.description.countryEuropean Patent Office -
patents.date.granted2013-04-24-
dc.relation.referencesCN 101721748 (A) 2010-06-09 -
dc.relation.references C N101721748 (B) 2013-04-10-
dc.relation.referencesCN 101439204 (A) 2009-05-27 -
dc.relation.references C N101439204 (B) 2012-09-05-
dc.relation.referencesWO 2006079854 (A1) 2006-08-03-
dc.relation.referencesWO 2009142770 (A2) 2009-11-26 -
dc.relation.references W O2009142770 (A3) 2010-01-14-
patents.identifier.hkutechidME-2010-00362-3-
patents.identifier.hkutechidME-2010-00362-4-
patents.identifier.hkutechidME-2010-00362-5-
patents.identifier.hkutechidME-2010-00362-6-
patents.date.application2011-06-15-
patents.date.priority2010-06-15 US 12/354869P-
patents.date.priority2011-06-15 PCT/CN2011000988-
patents.description.ccep-
patents.relation.familyCN 102971019 (A) 2013-03-13-
patents.relation.familyUS 2012148632 (A1) 2012-06-14-
patents.relation.familyWO 2011157057 (A1) 2011-12-22-
patents.description.kindA1-
patents.typePatent_granted-

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