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Article: A comparison of two prostaglandin analogues (enprostil vs misoprostol) in the treatment of acute duodenal ulcer disease

TitleA comparison of two prostaglandin analogues (enprostil vs misoprostol) in the treatment of acute duodenal ulcer disease
Authors
Issue Date1995
PublisherSpringer Japan. The Journal's web site is located at http://link.springer-ny.com/link/service/journals/00535/index.htm
Citation
Journal of Gastroenterology, 1995, v. 30 n. 5, p. 607-614 How to Cite?
AbstractWe conducted a clinical trial to compare the efficacy and safety profile of two prostaglandin analogues, enprostil (35 μg twice daily) and misoprostol (200 μg four times daily) in the treatment of acute duodenal ulcers in 214 patients. The two agents healed approximately 80% and in excess of 90% of duodenal ulcers after 4 and 6 weeks' therapy, respectively. There was a significantly lower ulcer healing rate in both treatment groups in smokers compared with nonsmokers (P<0.05). However, daytime and nighttime ulcer pain relief was achieved in fewer than 50% of patients by either agent. Diarrhea, which occurred in more than 40% of patients, was the predominant side effect, and occurred mainly during the first 2 weeks of therapy with either agent. Nevertheless, this side effect was mild and self-limiting in the majority of patients. Both agents were found to be safe and well tolerated by the majority of patients. We conclude that these prostaglandin analogues are safe and effective duodenal ulcer healing agents. Furthermore, there was very little difference between enprostil and misoprostol. The limiting factors, however, for their routine use as ulcer healing agents are their low efficacy with regard to ulcer pain relief and the high incidence of diarrhea.
Persistent Identifierhttp://hdl.handle.net/10722/225154
ISSN
2015 Impact Factor: 4.414
2015 SCImago Journal Rankings: 1.651

 

DC FieldValueLanguage
dc.contributor.authorChing, CK-
dc.contributor.authorLam, SK-
dc.date.accessioned2016-04-25T04:37:45Z-
dc.date.available2016-04-25T04:37:45Z-
dc.date.issued1995-
dc.identifier.citationJournal of Gastroenterology, 1995, v. 30 n. 5, p. 607-614-
dc.identifier.issn0944-1174-
dc.identifier.urihttp://hdl.handle.net/10722/225154-
dc.description.abstractWe conducted a clinical trial to compare the efficacy and safety profile of two prostaglandin analogues, enprostil (35 μg twice daily) and misoprostol (200 μg four times daily) in the treatment of acute duodenal ulcers in 214 patients. The two agents healed approximately 80% and in excess of 90% of duodenal ulcers after 4 and 6 weeks' therapy, respectively. There was a significantly lower ulcer healing rate in both treatment groups in smokers compared with nonsmokers (P<0.05). However, daytime and nighttime ulcer pain relief was achieved in fewer than 50% of patients by either agent. Diarrhea, which occurred in more than 40% of patients, was the predominant side effect, and occurred mainly during the first 2 weeks of therapy with either agent. Nevertheless, this side effect was mild and self-limiting in the majority of patients. Both agents were found to be safe and well tolerated by the majority of patients. We conclude that these prostaglandin analogues are safe and effective duodenal ulcer healing agents. Furthermore, there was very little difference between enprostil and misoprostol. The limiting factors, however, for their routine use as ulcer healing agents are their low efficacy with regard to ulcer pain relief and the high incidence of diarrhea.-
dc.languageeng-
dc.publisherSpringer Japan. The Journal's web site is located at http://link.springer-ny.com/link/service/journals/00535/index.htm-
dc.relation.ispartofJournal of Gastroenterology-
dc.rightsThe final publication is available at Springer via http://dx.doi.org/[insert DOI]-
dc.subject.meshAnti-Ulcer Agents - adverse effects - therapeutic use-
dc.subject.meshDuodenal Ulcer - drug therapy - pathology-
dc.subject.meshEndoscopy, Digestive System-
dc.subject.meshEnprostil - adverse effects - therapeutic use-
dc.subject.meshMisoprostol - adverse effects - therapeutic use-
dc.titleA comparison of two prostaglandin analogues (enprostil vs misoprostol) in the treatment of acute duodenal ulcer disease-
dc.typeArticle-
dc.identifier.emailChing, CK: ckching@hkucc.hku.hk-
dc.identifier.emailLam, SK: hrmelsk@hkucc.hku.hk-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/BF02367786-
dc.identifier.pmid8574332-
dc.identifier.scopuseid_2-s2.0-0029152194-
dc.identifier.hkuros9715-
dc.identifier.volume30-
dc.identifier.issue5-
dc.identifier.spage607-
dc.identifier.epage614-
dc.publisher.placeJapan-

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