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Article: A thymus-independent (type 1) phosphoryicholine antigen isolated from Trichinella spiralis protects mice against pneumococcal infection

TitleA thymus-independent (type 1) phosphoryicholine antigen isolated from Trichinella spiralis protects mice against pneumococcal infection
Authors
Issue Date1990
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/IMM
Citation
Immunology, 1990, v. 69 n. 3, p. 443-448 How to Cite?
AbstractA phosphorylcholine (PC)-containing glycoprotein of 68,000 molecular weight (MW) was isolated from Trichinella spiralis. The potential of this antigen (Tsp) as a species-specific vaccine against Streptococcus pneumoniae was studied in both immunologically deficient (CBA/N) and normal (CFW) mice. Unlike the PC determinant found in S. pneumoniae, Tsp is a type 1 thymus-independent (TI-1) antigen, as it was able to stimulate PC-specific antibody production in CBA/N animals, though less well than in CFW mice. Immunological memory to this antigen was observed in both strains of mice, and the predominant class of antibodies formed was IgM. In further studies, Tsp-immunized CFW mice were protected against a fatal challenge of S. pneumoniae type 3. Protection in these animals is probably mediated by the PC-specific antibodies present, which comprised 87.9% of antibodies reactive to S. pneumoniae, or 58.7% of total antibodies formed.
Persistent Identifierhttp://hdl.handle.net/10722/225105
ISSN
2015 Impact Factor: 4.078
2015 SCImago Journal Rankings: 2.038
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorLim, PL-
dc.contributor.authorChoy, WF-
dc.date.accessioned2016-04-21T02:27:38Z-
dc.date.available2016-04-21T02:27:38Z-
dc.date.issued1990-
dc.identifier.citationImmunology, 1990, v. 69 n. 3, p. 443-448-
dc.identifier.issn0019-2805-
dc.identifier.urihttp://hdl.handle.net/10722/225105-
dc.description.abstractA phosphorylcholine (PC)-containing glycoprotein of 68,000 molecular weight (MW) was isolated from Trichinella spiralis. The potential of this antigen (Tsp) as a species-specific vaccine against Streptococcus pneumoniae was studied in both immunologically deficient (CBA/N) and normal (CFW) mice. Unlike the PC determinant found in S. pneumoniae, Tsp is a type 1 thymus-independent (TI-1) antigen, as it was able to stimulate PC-specific antibody production in CBA/N animals, though less well than in CFW mice. Immunological memory to this antigen was observed in both strains of mice, and the predominant class of antibodies formed was IgM. In further studies, Tsp-immunized CFW mice were protected against a fatal challenge of S. pneumoniae type 3. Protection in these animals is probably mediated by the PC-specific antibodies present, which comprised 87.9% of antibodies reactive to S. pneumoniae, or 58.7% of total antibodies formed.-
dc.languageeng-
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/IMM-
dc.relation.ispartofImmunology-
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.subject.meshAntigens, Helminth - therapeutic use-
dc.subject.meshCholine - analogs & derivatives-
dc.subject.meshPhosphorylcholine - immunology-
dc.subject.meshPneumococcal Infections - prevention & control-
dc.subject.meshTrichinella - immunology-
dc.titleA thymus-independent (type 1) phosphoryicholine antigen isolated from Trichinella spiralis protects mice against pneumococcal infection-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.pmid2312167-
dc.identifier.pmcidPMC1385965-
dc.identifier.volume69-
dc.identifier.issue3-
dc.identifier.spage443-
dc.identifier.epage448-
dc.publisher.placeUnited Kingdom-

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