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Article: A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect

TitleA synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect
Authors
Issue Date2010
Citation
Journal of Medicinal Chemistry, 2010, v. 53, n. 23, p. 8274-8286 How to Cite?
Abstract7,8-Dihydroxyflavone is a recently identified small molecular tropomyosin-receptor-kinase B (TrkB) agonist. Our preliminary structural-activity relationship (SAR) study showed that the 7,8-dihydroxy groups are essential for the agonistic effect. To improve the lead compound's agonistic activity, we have conducted an extensive SAR study and synthesized numerous derivatives. We have successfully identified 4′-dimethylamino-7, 8-dihydroxyflavone that displays higher TrkB agonistic activity than that of the lead. This novel compound also exhibits a more robust and longer TrkB activation effect in animals. Consequently, this new compound reveals more potent antiapoptotic activity. Interestingly, chronic oral administration of 4′-dimethylamino-7,8-dihydroxyflavone and its lead strongly promotes neurogenesis in dentate gyrus and demonstrates marked antidepressant effects. Hence, our data support that the synthetic 4′-dimethylamino-7,8- dihydroxyflavone and its lead both are orally bioavailable TrkB agonists and possess potent antidepressant effects. © 2010 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/225086
ISSN
2015 Impact Factor: 5.589
2015 SCImago Journal Rankings: 2.529

 

DC FieldValueLanguage
dc.contributor.authorLiu, Xia-
dc.contributor.authorChan, Chi Bun-
dc.contributor.authorJang, Sung Wuk-
dc.contributor.authorPradoldej, Sompol-
dc.contributor.authorHuang, Junjian-
dc.contributor.authorHe, Kunyan-
dc.contributor.authorPhun, Lien H.-
dc.contributor.authorFrance, Stefan-
dc.contributor.authorXiao, Ge-
dc.contributor.authorJia, Yonghui-
dc.contributor.authorLuo, Hongbo R.-
dc.contributor.authorYe, Keqiang-
dc.date.accessioned2016-04-18T11:16:44Z-
dc.date.available2016-04-18T11:16:44Z-
dc.date.issued2010-
dc.identifier.citationJournal of Medicinal Chemistry, 2010, v. 53, n. 23, p. 8274-8286-
dc.identifier.issn0022-2623-
dc.identifier.urihttp://hdl.handle.net/10722/225086-
dc.description.abstract7,8-Dihydroxyflavone is a recently identified small molecular tropomyosin-receptor-kinase B (TrkB) agonist. Our preliminary structural-activity relationship (SAR) study showed that the 7,8-dihydroxy groups are essential for the agonistic effect. To improve the lead compound's agonistic activity, we have conducted an extensive SAR study and synthesized numerous derivatives. We have successfully identified 4′-dimethylamino-7, 8-dihydroxyflavone that displays higher TrkB agonistic activity than that of the lead. This novel compound also exhibits a more robust and longer TrkB activation effect in animals. Consequently, this new compound reveals more potent antiapoptotic activity. Interestingly, chronic oral administration of 4′-dimethylamino-7,8-dihydroxyflavone and its lead strongly promotes neurogenesis in dentate gyrus and demonstrates marked antidepressant effects. Hence, our data support that the synthetic 4′-dimethylamino-7,8- dihydroxyflavone and its lead both are orally bioavailable TrkB agonists and possess potent antidepressant effects. © 2010 American Chemical Society.-
dc.languageeng-
dc.relation.ispartofJournal of Medicinal Chemistry-
dc.titleA synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1021/jm101206p-
dc.identifier.pmid21073191-
dc.identifier.scopuseid_2-s2.0-78649857797-
dc.identifier.volume53-
dc.identifier.issue23-
dc.identifier.spage8274-
dc.identifier.epage8286-
dc.identifier.eissn1520-4804-

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