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Article: Deoxygedunin, a natural product with potent neurotrophic activity in mice

TitleDeoxygedunin, a natural product with potent neurotrophic activity in mice
Authors
Issue Date2010
Citation
PLoS ONE, 2010, v. 5, n. 7 How to Cite?
AbstractGedunin, a family of natural products from the Indian neem tree, possess a variety of biological activities. Here we report the discovery of deoxygedunin, which activates the mouse TrkB receptor and its downstream signaling cascades. Deoxygedunin is orally available and activates TrkB in mouse brain in a BDNF-independent way. Strikingly, it prevents the degeneration of vestibular ganglion in BDNF -/- pups. Moreover, deoxygedunin robustly protects rat neurons from cell death in a TrkBdependent manner. Further, administration of deoxygedunin into mice displays potent neuroprotective, anti-depressant and learning enhancement effects, all of which are mediated by the TrkB receptor. Hence, deoxygedunin imitates BDNF's biological activities through activating TrkB, providing a powerful therapeutic tool for treatment of various neurological diseases. © 2010 Jang et al.
Persistent Identifierhttp://hdl.handle.net/10722/225084

 

DC FieldValueLanguage
dc.contributor.authorJang, Sung Wuk-
dc.contributor.authorLiu, Xia-
dc.contributor.authorChan, Chi Bun-
dc.contributor.authorFrance, Stefan A.-
dc.contributor.authorSayeed, Iqbal-
dc.contributor.authorTang, Wenxue-
dc.contributor.authorLin, Xi-
dc.contributor.authorXiao, Ge-
dc.contributor.authorAndero, Raul-
dc.contributor.authorChang, Qiang-
dc.contributor.authorRessler, Kerry J.-
dc.contributor.authorYe, Keqiang-
dc.date.accessioned2016-04-18T11:16:44Z-
dc.date.available2016-04-18T11:16:44Z-
dc.date.issued2010-
dc.identifier.citationPLoS ONE, 2010, v. 5, n. 7-
dc.identifier.urihttp://hdl.handle.net/10722/225084-
dc.description.abstractGedunin, a family of natural products from the Indian neem tree, possess a variety of biological activities. Here we report the discovery of deoxygedunin, which activates the mouse TrkB receptor and its downstream signaling cascades. Deoxygedunin is orally available and activates TrkB in mouse brain in a BDNF-independent way. Strikingly, it prevents the degeneration of vestibular ganglion in BDNF -/- pups. Moreover, deoxygedunin robustly protects rat neurons from cell death in a TrkBdependent manner. Further, administration of deoxygedunin into mice displays potent neuroprotective, anti-depressant and learning enhancement effects, all of which are mediated by the TrkB receptor. Hence, deoxygedunin imitates BDNF's biological activities through activating TrkB, providing a powerful therapeutic tool for treatment of various neurological diseases. © 2010 Jang et al.-
dc.languageeng-
dc.relation.ispartofPLoS ONE-
dc.titleDeoxygedunin, a natural product with potent neurotrophic activity in mice-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1371/journal.pone.0011528-
dc.identifier.pmid20644624-
dc.identifier.scopuseid_2-s2.0-77955351134-
dc.identifier.volume5-
dc.identifier.issue7-
dc.identifier.eissn1932-6203-

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