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Article: Fyn regulates adipogenesis by promoting PIKE-A/STAT5a interaction

TitleFyn regulates adipogenesis by promoting PIKE-A/STAT5a interaction
Authors
Issue Date2013
Citation
Molecular and Cellular Biology, 2013, v. 33, n. 9, p. 1797-1808 How to Cite?
AbstractFyn is a tyrosine kinase with multiple roles in a variety of cellular processes. Here we report that Fyn is a new kinase involved in adipocyte differentiation. Elevated Fyn protein is detected specifically in the adipocytes of obese mice. Moreover, Fyn expression increases progressively in 3T3-L1 cells during in vitro adipogenesis, which correlates with its kinase activity. Inhibition of Fyn by either genetic or pharmacological manipulation restrains the 3T3-L1 preadipocytes from fully differentiating into mature adipocytes.Mechanistically, Fyn regulates the activity of the adipogenic transcription factor signal transducer and activator of transcription 5a (STAT5a) through enhancing its interaction with the GTPase phosphoinositide 3-kinase enhancer A (PIKE-A). The STAT5a activity is therefore reduced in Fyn- or PIKE-ablated adipose tissues, leading to diminished expression of adipogenic markers and adipocyte differentiation. Our data thus demonstrate a novel functional interaction between Fyn, PIKE-A, and STAT5a in mediating adipogenesis. © 2013, American Society for Microbiology.
Persistent Identifierhttp://hdl.handle.net/10722/225053
ISSN
2015 Impact Factor: 4.427
2015 SCImago Journal Rankings: 3.806

 

DC FieldValueLanguage
dc.contributor.authorTse, Margaret Chui Ling-
dc.contributor.authorLiu, Xia-
dc.contributor.authorYang, Seran-
dc.contributor.authorYe, Keqiang-
dc.contributor.authorChan, Chi Bun-
dc.date.accessioned2016-04-18T11:16:38Z-
dc.date.available2016-04-18T11:16:38Z-
dc.date.issued2013-
dc.identifier.citationMolecular and Cellular Biology, 2013, v. 33, n. 9, p. 1797-1808-
dc.identifier.issn0270-7306-
dc.identifier.urihttp://hdl.handle.net/10722/225053-
dc.description.abstractFyn is a tyrosine kinase with multiple roles in a variety of cellular processes. Here we report that Fyn is a new kinase involved in adipocyte differentiation. Elevated Fyn protein is detected specifically in the adipocytes of obese mice. Moreover, Fyn expression increases progressively in 3T3-L1 cells during in vitro adipogenesis, which correlates with its kinase activity. Inhibition of Fyn by either genetic or pharmacological manipulation restrains the 3T3-L1 preadipocytes from fully differentiating into mature adipocytes.Mechanistically, Fyn regulates the activity of the adipogenic transcription factor signal transducer and activator of transcription 5a (STAT5a) through enhancing its interaction with the GTPase phosphoinositide 3-kinase enhancer A (PIKE-A). The STAT5a activity is therefore reduced in Fyn- or PIKE-ablated adipose tissues, leading to diminished expression of adipogenic markers and adipocyte differentiation. Our data thus demonstrate a novel functional interaction between Fyn, PIKE-A, and STAT5a in mediating adipogenesis. © 2013, American Society for Microbiology.-
dc.languageeng-
dc.relation.ispartofMolecular and Cellular Biology-
dc.titleFyn regulates adipogenesis by promoting PIKE-A/STAT5a interaction-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1128/MCB.01410-12-
dc.identifier.pmid23438599-
dc.identifier.scopuseid_2-s2.0-84876453706-
dc.identifier.volume33-
dc.identifier.issue9-
dc.identifier.spage1797-
dc.identifier.epage1808-
dc.identifier.eissn1098-5549-

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