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Article: PIKE GTPase are phosphoinositide-3-kinase enhancers, suppressing programmed cell death

TitlePIKE GTPase are phosphoinositide-3-kinase enhancers, suppressing programmed cell death
Authors
KeywordsAkt
PIKE
PI3K
GTPase
Apoptosis
Issue Date2007
Citation
Journal of Cellular and Molecular Medicine, 2007, v. 11, n. 1, p. 39-53 How to Cite?
AbstractPhosphoinositide-3-kinase enhancers (PIKE) are GTP-binding proteins that posses anti-apoptotic functions. The PIKE family includes three members, PIKE-L, PIKE-S and PIKE-A, which are originated from a single gene (CENTG1) through alternative splicing or differential transcription initiation. Both PIKE-S and PIKE-L bind to phosphoinositide-3-kinase (PI3K) and enhance its activity. PIKE-A does not interplay with PI3K. Instead, it interacts with the downstream effector Akt and promotes its activity. These actions are mediated by their GTPase activity. Because both PI3K and Akt are important effectors in the growth factor-mediated signaling which triggers cellular growth and acts against apoptosis, PIKEs therefore serve as the molecular switch that their activation are crucial for growth factors to exert their physiological functions. In this review, the current understanding of different PIKE isoforms in growth factors-induced anti-apoptotic function will be discussed. Moreover, the role of PIKE in the survival and invasion activity of cancer cells will also be introduced. © 2007 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/225031
ISSN
2012 Impact Factor: 4.753
2015 SCImago Journal Rankings: 1.941

 

DC FieldValueLanguage
dc.contributor.authorChan, Chi Bun-
dc.contributor.authorYe, Keqiang-
dc.date.accessioned2016-04-18T11:16:34Z-
dc.date.available2016-04-18T11:16:34Z-
dc.date.issued2007-
dc.identifier.citationJournal of Cellular and Molecular Medicine, 2007, v. 11, n. 1, p. 39-53-
dc.identifier.issn1582-1838-
dc.identifier.urihttp://hdl.handle.net/10722/225031-
dc.description.abstractPhosphoinositide-3-kinase enhancers (PIKE) are GTP-binding proteins that posses anti-apoptotic functions. The PIKE family includes three members, PIKE-L, PIKE-S and PIKE-A, which are originated from a single gene (CENTG1) through alternative splicing or differential transcription initiation. Both PIKE-S and PIKE-L bind to phosphoinositide-3-kinase (PI3K) and enhance its activity. PIKE-A does not interplay with PI3K. Instead, it interacts with the downstream effector Akt and promotes its activity. These actions are mediated by their GTPase activity. Because both PI3K and Akt are important effectors in the growth factor-mediated signaling which triggers cellular growth and acts against apoptosis, PIKEs therefore serve as the molecular switch that their activation are crucial for growth factors to exert their physiological functions. In this review, the current understanding of different PIKE isoforms in growth factors-induced anti-apoptotic function will be discussed. Moreover, the role of PIKE in the survival and invasion activity of cancer cells will also be introduced. © 2007 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd.-
dc.languageeng-
dc.relation.ispartofJournal of Cellular and Molecular Medicine-
dc.subjectAkt-
dc.subjectPIKE-
dc.subjectPI3K-
dc.subjectGTPase-
dc.subjectApoptosis-
dc.titlePIKE GTPase are phosphoinositide-3-kinase enhancers, suppressing programmed cell death-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1582-4934.2007.00014.x-
dc.identifier.pmid17367500-
dc.identifier.scopuseid_2-s2.0-33947306609-
dc.identifier.volume11-
dc.identifier.issue1-
dc.identifier.spage39-
dc.identifier.epage53-

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