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Article: Ambient particulate pollution and the world-wide prevalence of asthma, rhinoconjunctivitis and eczema in children: Phase One of the International Study of Asthma and Allergies in Childhood (ISAAC)

TitleAmbient particulate pollution and the world-wide prevalence of asthma, rhinoconjunctivitis and eczema in children: Phase One of the International Study of Asthma and Allergies in Childhood (ISAAC)
Authors
KeywordsAsthma - epidemiology
Conjunctivitis, Allergic - epidemiology
Eczema - epidemiology
Particulate Matter - analysis - toxicity
Rhinitis, Allergic, Perennial - epidemiology
Issue Date2010
PublisherBMJ Publishing Group. The Journal's web site is located at http://www.occenvmed.com
Citation
Occupational and Environmental Medicine, 2010, v. 67 n. 5, p. 293-300 How to Cite?
AbstractOBJECTIVES: To investigate the effect of ambient particulate matter on variation in childhood prevalence of asthma, rhinoconjunctivitis and eczema. METHODS: Prevalences of asthma, rhinoconjunctivitis and eczema obtained in Phase One of the International Study of Asthma and Allergies in Childhood (ISAAC) were matched with city-level estimates of residential PM(10) obtained from a World Bank model. Associations were investigated using binomial regression adjusting for GNP per capita and for clustering within country. For countries with more than one centre, a two stage meta-analysis was carried out. The results were compared with a meta-analysis of published multi-centre studies. RESULTS: Annual concentrations of PM(10) at city level were obtained for 105 ISAAC centres in 51 countries. After controlling for GNP per capita, there was a weak negative association between PM(10) and various outcomes. For severe wheeze in 13-14-year-olds, the OR for a 10 microg/m(3) increase in PM(10) was 0.92 (95% CI 0.84 to 1.00). In 24 countries with more than one centre, most summary estimates for within-country associations were weakly positive. For severe wheeze in 13-14-year-olds, the summary OR for a 10 microg/m(3) increase in PM(10) was 1.01 (0.92 to 1.10). This result was close to a summary OR of 0.99 (0.91 to 1.06) obtained from published multi-centre studies. CONCLUSIONS: Modelled estimates of particulate matter at city level are imprecise and incomplete estimates of personal exposure to ambient air pollutants. Nevertheless, our results together with those of previous multi-centre studies, suggest that urban background PM(10) has little or no association with the prevalence of childhood asthma, rhinoconjunctivitis or eczema either within or between countries.
Persistent Identifierhttp://hdl.handle.net/10722/224745
ISSN
2015 Impact Factor: 3.745
2015 SCImago Journal Rankings: 1.597

 

DC FieldValueLanguage
dc.contributor.authorAnderson, HR-
dc.contributor.authorRuggles, R-
dc.contributor.authorPandey, KD-
dc.contributor.authorKapetanakis, V-
dc.contributor.authorBrunekreef, B-
dc.contributor.authorLai, CKW-
dc.contributor.authorStrachan, DP-
dc.contributor.authorWeiland, SK-
dc.contributor.authorThe ISAAC Phase One Study Group,-
dc.contributor.authorLau, YL-
dc.date.accessioned2016-04-14T02:30:22Z-
dc.date.available2016-04-14T02:30:22Z-
dc.date.issued2010-
dc.identifier.citationOccupational and Environmental Medicine, 2010, v. 67 n. 5, p. 293-300-
dc.identifier.issn1351-0711-
dc.identifier.urihttp://hdl.handle.net/10722/224745-
dc.description.abstractOBJECTIVES: To investigate the effect of ambient particulate matter on variation in childhood prevalence of asthma, rhinoconjunctivitis and eczema. METHODS: Prevalences of asthma, rhinoconjunctivitis and eczema obtained in Phase One of the International Study of Asthma and Allergies in Childhood (ISAAC) were matched with city-level estimates of residential PM(10) obtained from a World Bank model. Associations were investigated using binomial regression adjusting for GNP per capita and for clustering within country. For countries with more than one centre, a two stage meta-analysis was carried out. The results were compared with a meta-analysis of published multi-centre studies. RESULTS: Annual concentrations of PM(10) at city level were obtained for 105 ISAAC centres in 51 countries. After controlling for GNP per capita, there was a weak negative association between PM(10) and various outcomes. For severe wheeze in 13-14-year-olds, the OR for a 10 microg/m(3) increase in PM(10) was 0.92 (95% CI 0.84 to 1.00). In 24 countries with more than one centre, most summary estimates for within-country associations were weakly positive. For severe wheeze in 13-14-year-olds, the summary OR for a 10 microg/m(3) increase in PM(10) was 1.01 (0.92 to 1.10). This result was close to a summary OR of 0.99 (0.91 to 1.06) obtained from published multi-centre studies. CONCLUSIONS: Modelled estimates of particulate matter at city level are imprecise and incomplete estimates of personal exposure to ambient air pollutants. Nevertheless, our results together with those of previous multi-centre studies, suggest that urban background PM(10) has little or no association with the prevalence of childhood asthma, rhinoconjunctivitis or eczema either within or between countries.-
dc.languageeng-
dc.publisherBMJ Publishing Group. The Journal's web site is located at http://www.occenvmed.com-
dc.relation.ispartofOccupational and Environmental Medicine-
dc.rightsOccupational and Environmental Medicine. Copyright © BMJ Publishing Group.-
dc.subjectAsthma - epidemiology-
dc.subjectConjunctivitis, Allergic - epidemiology-
dc.subjectEczema - epidemiology-
dc.subjectParticulate Matter - analysis - toxicity-
dc.subjectRhinitis, Allergic, Perennial - epidemiology-
dc.titleAmbient particulate pollution and the world-wide prevalence of asthma, rhinoconjunctivitis and eczema in children: Phase One of the International Study of Asthma and Allergies in Childhood (ISAAC)-
dc.typeArticle-
dc.identifier.emailAnderson, HR: r.anderson@sgul.ac.uk-
dc.identifier.emailLau, YL: lauylung@hkucc.hku.hk-
dc.identifier.authorityLau, YL=rp00361-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1136/oem.2009.048785-
dc.identifier.pmid19819866-
dc.identifier.hkuros170260-
dc.identifier.volume67-
dc.identifier.issue5-
dc.identifier.spage293-
dc.identifier.epage300-
dc.publisher.placeUnited Kingdom-

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