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Article: Congenital Duodenal Atresia in Rat Model Induced by Adriamycin

TitleCongenital Duodenal Atresia in Rat Model Induced by Adriamycin
阿霉素誘導十二指腸閉鎖的實驗研究
Authors
KeywordsAdriamycin (阿霉素)
Duodenal atresia (十二指腸閉鎖)
Issue Date1999
PublisherZhonghua Yi Xue Hui Wuhan Fen Hui (中華醫學會武漢分會). The Journal's web site is located at http://med.wanfangdata.com.cn/Paper/PeriodicalInfo.aspx?periodicalID=xrwk
Citation
Chinese Journal of Pediatric Surgery, 1999, v. 20 n. 3, p. 170-171, 193 How to Cite?
中華小兒外科雜誌, 1999, v. 20 n. 3, p. 170-171, 193 How to Cite?
AbstractObjective To describe a reprducible fetal model of duedenal atresia. Methods Themated Pregnant rats were given 1. 75 rug/kg of Adriamycin intraperitoneally on days 6 through 9 of gestation, and the litters were recovered on day 20. The fetuses were dissected microscopically and studied histologically. The findings were compared with those of age-matched saline embryos. Results All saline embryos were normal, whereas 81. 7% (26/32) of Adriamycin ernbryoo had duodenal atresia. The intralumi-nal atresia was found in 15. 4% (4/26) of duedenal atresia embryos, gapped atresia with pancreatic tissuefilled in between in 46. 2% (12/26) and gapped atresia in 38. 5 % (10/26). A double duedenal atresia wasfound in one fetus. The malformation was anatomically identical to that of human human. Interestingly,all duedenal atresia embryco were saaociated with pancreatic agenesis, in 34. 6 % with the pancreatic neck,ho and tail absence and in 65. 4% with the body and tail absence. Conclusion This easily repnducibleexperimental model permits new research into both its embryogenesis and the biology if the duedenal atresiafetus. 目的制作阿霉素誘導大白鼠胎仔出現先天性十二指腸閉鎖的模型。方法Wistar孕鼠10只,于妊娠第6至第9天腹腔注射阿霉素175mp/kg,妊娠20天剖宮取胎仔,做解剖、電鏡及光鏡觀察。結果用藥組獲胎仔32只,十二指腸閉鎖26例(81.3%),其中腔內閉鎖15.4%,閉鎖近遠端由纖維或胰腺相連者占46.2%,近遠端游離者為38.5%,十二指腸閉鎖畸形均伴有胰腺發育異常,9例胰頸、胰體及胰尾缺如,17例胰體和胰尾缺如,另外,鏡下見部分胰腺腺泡呈發育不良改變。結論阿霉素誘導大鼠胎仔出現先天性十二指腸畸形和胰腺畸形是一種可靠的模型制作方法。
Persistent Identifierhttp://hdl.handle.net/10722/224709
ISSN

 

DC FieldValueLanguage
dc.contributor.authorChen, YC-
dc.contributor.authorLi, L-
dc.contributor.authorDiao, M-
dc.contributor.authorHe, LJ-
dc.contributor.authorZhang, JZ-
dc.contributor.authorCheng, W-
dc.date.accessioned2016-04-13T01:03:26Z-
dc.date.available2016-04-13T01:03:26Z-
dc.date.issued1999-
dc.identifier.citationChinese Journal of Pediatric Surgery, 1999, v. 20 n. 3, p. 170-171, 193-
dc.identifier.citation中華小兒外科雜誌, 1999, v. 20 n. 3, p. 170-171, 193-
dc.identifier.issn0253-3006-
dc.identifier.urihttp://hdl.handle.net/10722/224709-
dc.description.abstractObjective To describe a reprducible fetal model of duedenal atresia. Methods Themated Pregnant rats were given 1. 75 rug/kg of Adriamycin intraperitoneally on days 6 through 9 of gestation, and the litters were recovered on day 20. The fetuses were dissected microscopically and studied histologically. The findings were compared with those of age-matched saline embryos. Results All saline embryos were normal, whereas 81. 7% (26/32) of Adriamycin ernbryoo had duodenal atresia. The intralumi-nal atresia was found in 15. 4% (4/26) of duedenal atresia embryos, gapped atresia with pancreatic tissuefilled in between in 46. 2% (12/26) and gapped atresia in 38. 5 % (10/26). A double duedenal atresia wasfound in one fetus. The malformation was anatomically identical to that of human human. Interestingly,all duedenal atresia embryco were saaociated with pancreatic agenesis, in 34. 6 % with the pancreatic neck,ho and tail absence and in 65. 4% with the body and tail absence. Conclusion This easily repnducibleexperimental model permits new research into both its embryogenesis and the biology if the duedenal atresiafetus. 目的制作阿霉素誘導大白鼠胎仔出現先天性十二指腸閉鎖的模型。方法Wistar孕鼠10只,于妊娠第6至第9天腹腔注射阿霉素175mp/kg,妊娠20天剖宮取胎仔,做解剖、電鏡及光鏡觀察。結果用藥組獲胎仔32只,十二指腸閉鎖26例(81.3%),其中腔內閉鎖15.4%,閉鎖近遠端由纖維或胰腺相連者占46.2%,近遠端游離者為38.5%,十二指腸閉鎖畸形均伴有胰腺發育異常,9例胰頸、胰體及胰尾缺如,17例胰體和胰尾缺如,另外,鏡下見部分胰腺腺泡呈發育不良改變。結論阿霉素誘導大鼠胎仔出現先天性十二指腸畸形和胰腺畸形是一種可靠的模型制作方法。-
dc.languagechi-
dc.publisherZhonghua Yi Xue Hui Wuhan Fen Hui (中華醫學會武漢分會). The Journal's web site is located at http://med.wanfangdata.com.cn/Paper/PeriodicalInfo.aspx?periodicalID=xrwk-
dc.relation.ispartofChinese Journal of Pediatric Surgery-
dc.relation.ispartof中華小兒外科雜誌-
dc.subjectAdriamycin (阿霉素)-
dc.subjectDuodenal atresia (十二指腸閉鎖)-
dc.titleCongenital Duodenal Atresia in Rat Model Induced by Adriamycin-
dc.title阿霉素誘導十二指腸閉鎖的實驗研究-
dc.typeArticle-
dc.identifier.emailCheng, W: weicheng@hkucc.hku.hk-
dc.identifier.hkuros47950-
dc.identifier.volume20-
dc.identifier.issue3-
dc.identifier.spage170-
dc.identifier.epage171, 193-
dc.publisher.placeChina (中國)-

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