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Conference Paper: Liver stiffness and histological features in healthy persons, and patients with occult hepatitis B, chronic active hepatitis B, and hepatitis B-related cirrhosis.

TitleLiver stiffness and histological features in healthy persons, and patients with occult hepatitis B, chronic active hepatitis B, and hepatitis B-related cirrhosis.
Authors
Issue Date2009
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.hepatology.org/
Citation
The American Assoication for the Study of Liver Diseases 60th Annual Meeting and Postgraduate Course - The Liver Meeting, Boston, MA, 30 October - 3 November 2009。 In Hepatology, 2009, v. 50 n. 4 Suppl, p. 978A-979A Abstract no. 1465 How to Cite?
AbstractBackground: Liver stiffness measurement using transient elas-tography has become a popular tool to assess liver fibrosis.Aim: To determine liver stiffness values and histological featuresin healthy subjects and patients with chronic hepatitis B.Patients and Methods: A total of 157 persons were included(28 healthy subjects, 18 occult hepatitis B infection, 102 activechronic hepatitis B, and 9 end-stage hepatitis B cirrhosis). His-tology and liver stiffness measurements were obtained from allpatients. Results: The median liver stiffness in healthy subjects,occult hepatitis B, active hepatitis B, and end-stage cirrhosiswere 4.6, 4.2, 8.7, and 33.8 kPa respectively, with signifi-cantly higher values in the latter 2 groups compared to the for-mer 2 groups (p<0.001). In healthy subjects and patients with occult hepatitis B infection, no one had significant fibrosis onhistology and all had liver stiffness <7.2 kPa. In patients withchronic active hepatitis B, 32 (31%) had liver stiffness >11.0kPa, but only 4 (12%) had cirrhosis on histology. Using liverstiffness to predict cirrhosis in this group had a sensitivity of100%, specificity of 69%, a positive predictive value of 10%,and a negative predictive value of 100%. All 9 patients withend-stage liver cirrhosis had liver stiffness >11.0 kPa. The over-all AUROC for diagnosing cirrhosis using a cut-off of 11.3 kPawas 0.89. Conclusion: Liver stiffness measurement has an over-all good diagnostic accuracy with excellent negative predictivevalue. In chronic active hepatitis B, the diagnostic accuracymay be reduced when underlying inflammatory activity issevere.
Persistent Identifierhttp://hdl.handle.net/10722/224432
ISSN
2015 Impact Factor: 11.711
2015 SCImago Journal Rankings: 4.752

 

DC FieldValueLanguage
dc.contributor.authorFung, JYY-
dc.contributor.authorLai, CL-
dc.contributor.authorChan, SC-
dc.contributor.authorBut, D-
dc.contributor.authorSeto, WKW-
dc.contributor.authorCheng, CTK-
dc.contributor.authorWong, DKH-
dc.contributor.authorLo, CM-
dc.contributor.authorFan, ST-
dc.contributor.authorYuen, RMF-
dc.date.accessioned2016-04-05T04:20:41Z-
dc.date.available2016-04-05T04:20:41Z-
dc.date.issued2009-
dc.identifier.citationThe American Assoication for the Study of Liver Diseases 60th Annual Meeting and Postgraduate Course - The Liver Meeting, Boston, MA, 30 October - 3 November 2009。 In Hepatology, 2009, v. 50 n. 4 Suppl, p. 978A-979A Abstract no. 1465-
dc.identifier.issn0270-9139-
dc.identifier.urihttp://hdl.handle.net/10722/224432-
dc.description.abstractBackground: Liver stiffness measurement using transient elas-tography has become a popular tool to assess liver fibrosis.Aim: To determine liver stiffness values and histological featuresin healthy subjects and patients with chronic hepatitis B.Patients and Methods: A total of 157 persons were included(28 healthy subjects, 18 occult hepatitis B infection, 102 activechronic hepatitis B, and 9 end-stage hepatitis B cirrhosis). His-tology and liver stiffness measurements were obtained from allpatients. Results: The median liver stiffness in healthy subjects,occult hepatitis B, active hepatitis B, and end-stage cirrhosiswere 4.6, 4.2, 8.7, and 33.8 kPa respectively, with signifi-cantly higher values in the latter 2 groups compared to the for-mer 2 groups (p<0.001). In healthy subjects and patients with occult hepatitis B infection, no one had significant fibrosis onhistology and all had liver stiffness <7.2 kPa. In patients withchronic active hepatitis B, 32 (31%) had liver stiffness >11.0kPa, but only 4 (12%) had cirrhosis on histology. Using liverstiffness to predict cirrhosis in this group had a sensitivity of100%, specificity of 69%, a positive predictive value of 10%,and a negative predictive value of 100%. All 9 patients withend-stage liver cirrhosis had liver stiffness >11.0 kPa. The over-all AUROC for diagnosing cirrhosis using a cut-off of 11.3 kPawas 0.89. Conclusion: Liver stiffness measurement has an over-all good diagnostic accuracy with excellent negative predictivevalue. In chronic active hepatitis B, the diagnostic accuracymay be reduced when underlying inflammatory activity issevere.-
dc.languageeng-
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.hepatology.org/-
dc.relation.ispartofHepatology-
dc.rightsHepatology. Copyright © John Wiley & Sons, Inc.-
dc.rightsSpecial Statement for Preprint only Before publication: 'This is a preprint of an article accepted for publication in [The Journal of Pathology] Copyright © ([year]) ([Pathological Society of Great Britain and Ireland])'. After publication: the preprint notice should be amended to follows: 'This is a preprint of an article published in [include the complete citation information for the final version of the Contribution as published in the print edition of the Journal]' For Cochrane Library/ Cochrane Database of Systematic Reviews, add statement & acknowledgement : ‘This review is published as a Cochrane Review in the Cochrane Database of Systematic Reviews 20XX, Issue X. Cochrane Reviews are regularly updated as new evidence emerges and in response to comments and criticisms, and the Cochrane Database of Systematic Reviews should be consulted for the most recent version of the Review.’ Please include reference to the Review and hyperlink to the original version using the following format e.g. Authors. Title of Review. Cochrane Database of Systematic Reviews 20XX, Issue #. Art. No.: CD00XXXX. DOI: 10.1002/14651858.CD00XXXX (insert persistent link to the article by using the URL: http://dx.doi.org/10.1002/14651858.CD00XXXX) (This statement should refer to the most recent issue of the Cochrane Database of Systematic Reviews in which the Review published.)-
dc.titleLiver stiffness and histological features in healthy persons, and patients with occult hepatitis B, chronic active hepatitis B, and hepatitis B-related cirrhosis.-
dc.typeConference_Paper-
dc.identifier.emailFung, JYY: jfung@sicklehut.com-
dc.identifier.emailLai, CL: hrmelcl@hku.hk-
dc.identifier.emailChan, SC: seechingchan@gmail.com-
dc.identifier.emailSeto, WKW: wkseto@hku.hk-
dc.identifier.emailCheng, CTK: ctkcheng@HKUCC.hku.hk-
dc.identifier.emailWong, DKH: danywong@hku.hk-
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hk-
dc.identifier.emailFan, ST: stfan@hku.hk-
dc.identifier.emailYuen, RMF: mfyuen@hkucc.hku.hk-
dc.identifier.authorityFung, JYY=rp00518-
dc.identifier.authorityLai, CL=rp00314-
dc.identifier.authorityChan, SC=rp01568-
dc.identifier.authoritySeto, WKW=rp01659-
dc.identifier.authorityWong, DKH=rp00492-
dc.identifier.authorityLo, CM=rp00412-
dc.identifier.authorityFan, ST=rp00355-
dc.identifier.authorityYuen, RMF=rp00479-
dc.identifier.doi10.1002/hep.23306-
dc.identifier.hkuros181236-
dc.identifier.volume50-
dc.identifier.issue4 Suppl-
dc.identifier.spage978A-
dc.identifier.epage979A Abstract no. 1465-
dc.publisher.placeUnited States-

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