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Conference Paper: Liver stiffness and histological features in healthy persons, and patients with occult hepatitis B, chronic active hepatitis B, and hepatitis B-related cirrhosis.

TitleLiver stiffness and histological features in healthy persons, and patients with occult hepatitis B, chronic active hepatitis B, and hepatitis B-related cirrhosis.
Authors
Issue Date2009
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.hepatology.org/
Citation
The 60th Annual Meeting and Postgraduate Course of the American Assoication for the Study of Liver Diseases (The Liver Meeting® 2009), Boston, MA., 30 October-3 November 2009. In Hepatology, 2009, v. 50 n. 4 suppl., p. 978A-979A, abstract no. 1465 How to Cite?
AbstractBackground: Liver stiffness measurement using transient elas-tography has become a popular tool to assess liver fibrosis.Aim: To determine liver stiffness values and histological featuresin healthy subjects and patients with chronic hepatitis B.Patients and Methods: A total of 157 persons were included(28 healthy subjects, 18 occult hepatitis B infection, 102 activechronic hepatitis B, and 9 end-stage hepatitis B cirrhosis). His-tology and liver stiffness measurements were obtained from allpatients. Results: The median liver stiffness in healthy subjects,occult hepatitis B, active hepatitis B, and end-stage cirrhosiswere 4.6, 4.2, 8.7, and 33.8 kPa respectively, with signifi-cantly higher values in the latter 2 groups compared to the for-mer 2 groups (p<0.001). In healthy subjects and patients with occult hepatitis B infection, no one had significant fibrosis onhistology and all had liver stiffness <7.2 kPa. In patients withchronic active hepatitis B, 32 (31%) had liver stiffness >11.0kPa, but only 4 (12%) had cirrhosis on histology. Using liverstiffness to predict cirrhosis in this group had a sensitivity of100%, specificity of 69%, a positive predictive value of 10%,and a negative predictive value of 100%. All 9 patients withend-stage liver cirrhosis had liver stiffness >11.0 kPa. The over-all AUROC for diagnosing cirrhosis using a cut-off of 11.3 kPawas 0.89. Conclusion: Liver stiffness measurement has an over-all good diagnostic accuracy with excellent negative predictivevalue. In chronic active hepatitis B, the diagnostic accuracymay be reduced when underlying inflammatory activity issevere.
Persistent Identifierhttp://hdl.handle.net/10722/224432
ISSN
2015 Impact Factor: 11.711
2015 SCImago Journal Rankings: 4.752

 

DC FieldValueLanguage
dc.contributor.authorFung, JYY-
dc.contributor.authorLai, CL-
dc.contributor.authorChan, SC-
dc.contributor.authorBut, D-
dc.contributor.authorSeto, WKW-
dc.contributor.authorCheng, CTK-
dc.contributor.authorWong, DKH-
dc.contributor.authorLo, CM-
dc.contributor.authorFan, ST-
dc.contributor.authorYuen, RMF-
dc.date.accessioned2016-04-05T04:20:41Z-
dc.date.available2016-04-05T04:20:41Z-
dc.date.issued2009-
dc.identifier.citationThe 60th Annual Meeting and Postgraduate Course of the American Assoication for the Study of Liver Diseases (The Liver Meeting® 2009), Boston, MA., 30 October-3 November 2009. In Hepatology, 2009, v. 50 n. 4 suppl., p. 978A-979A, abstract no. 1465-
dc.identifier.issn0270-9139-
dc.identifier.urihttp://hdl.handle.net/10722/224432-
dc.description.abstractBackground: Liver stiffness measurement using transient elas-tography has become a popular tool to assess liver fibrosis.Aim: To determine liver stiffness values and histological featuresin healthy subjects and patients with chronic hepatitis B.Patients and Methods: A total of 157 persons were included(28 healthy subjects, 18 occult hepatitis B infection, 102 activechronic hepatitis B, and 9 end-stage hepatitis B cirrhosis). His-tology and liver stiffness measurements were obtained from allpatients. Results: The median liver stiffness in healthy subjects,occult hepatitis B, active hepatitis B, and end-stage cirrhosiswere 4.6, 4.2, 8.7, and 33.8 kPa respectively, with signifi-cantly higher values in the latter 2 groups compared to the for-mer 2 groups (p<0.001). In healthy subjects and patients with occult hepatitis B infection, no one had significant fibrosis onhistology and all had liver stiffness <7.2 kPa. In patients withchronic active hepatitis B, 32 (31%) had liver stiffness >11.0kPa, but only 4 (12%) had cirrhosis on histology. Using liverstiffness to predict cirrhosis in this group had a sensitivity of100%, specificity of 69%, a positive predictive value of 10%,and a negative predictive value of 100%. All 9 patients withend-stage liver cirrhosis had liver stiffness >11.0 kPa. The over-all AUROC for diagnosing cirrhosis using a cut-off of 11.3 kPawas 0.89. Conclusion: Liver stiffness measurement has an over-all good diagnostic accuracy with excellent negative predictivevalue. In chronic active hepatitis B, the diagnostic accuracymay be reduced when underlying inflammatory activity issevere.-
dc.languageeng-
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.hepatology.org/-
dc.relation.ispartofHepatology-
dc.rightsHepatology. Copyright © John Wiley & Sons, Inc.-
dc.titleLiver stiffness and histological features in healthy persons, and patients with occult hepatitis B, chronic active hepatitis B, and hepatitis B-related cirrhosis.-
dc.typeConference_Paper-
dc.identifier.emailFung, JYY: jfung@sicklehut.com-
dc.identifier.emailLai, CL: hrmelcl@hku.hk-
dc.identifier.emailChan, SC: seechingchan@gmail.com-
dc.identifier.emailSeto, WKW: wkseto@hku.hk-
dc.identifier.emailCheng, CTK: ctkcheng@HKUCC.hku.hk-
dc.identifier.emailWong, DKH: danywong@hku.hk-
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hk-
dc.identifier.emailFan, ST: stfan@hku.hk-
dc.identifier.emailYuen, RMF: mfyuen@hkucc.hku.hk-
dc.identifier.authorityFung, JYY=rp00518-
dc.identifier.authorityLai, CL=rp00314-
dc.identifier.authorityChan, SC=rp01568-
dc.identifier.authoritySeto, WKW=rp01659-
dc.identifier.authorityWong, DKH=rp00492-
dc.identifier.authorityLo, CM=rp00412-
dc.identifier.authorityFan, ST=rp00355-
dc.identifier.authorityYuen, RMF=rp00479-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1002/hep.23306-
dc.identifier.hkuros181236-
dc.identifier.volume50-
dc.identifier.issue4 suppl.-
dc.identifier.spage978A, abstract no. 1465-
dc.identifier.epage979A-
dc.publisher.placeUnited States-

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