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Article: Atherosclerosis risk factors: The possible role of homocysteine

TitleAtherosclerosis risk factors: The possible role of homocysteine
Authors
Issue Date2000
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0300-8177
Citation
Molecular and Cellular Biochemistry, 2000, v. 207 n. 1-2, p. 143-148 How to Cite?
AbstractAtherosclerosis is the leading cause of death in North America. It is characterized by thickening of the coronary artery wall by the formation of plaques, resulting in reduced blood flow. Plaque rupture and the consequent thrombosis may lead to sudden blockage of arteries and causing stroke and heart attack. In the last several decades, more than 250 factors associated with the development of coronary artery disease have been identified. Recently, a relationship between atherosclerosis and elevated homocysteine level in the blood has been established. The mechanism for the production of atherosclerosis by homocysteine has been investigated. When human hepatoma cells (HepG2) were incubated with 4mM homocysteine, enhancements in the production of cholesterol and secretion of apolipoprotein B-100 were observed. The stimulatory effect on cholesterol synthesis was mediated via the enhancement of HMG-CoA reductase, which catalyzes the rate-limiting step in cholesterol biosynthesis. Cholesterol appears to play an important role in the regulation of apoB-100 secretion by hepatocytes. It is plausible that the increase in apoB secretion was caused by the elevated cholesterol level induced by homocysteine. The ability of homocysteine to produce a higher amount of cholesterol and promote the secretion of apoB would provide a plausible mechanism for the observed relationship between hyperhomocysteinemia and the development of atherogenesis and coronary artery disease.
Persistent Identifierhttp://hdl.handle.net/10722/224218
ISSN
2015 Impact Factor: 2.613
2015 SCImago Journal Rankings: 1.019

 

DC FieldValueLanguage
dc.contributor.authorChoy, PC-
dc.contributor.authorMymin, D-
dc.contributor.authorZhu, Q-
dc.contributor.authorDakshinamurti, K-
dc.contributor.authorO, K-
dc.date.accessioned2016-03-30T03:33:51Z-
dc.date.available2016-03-30T03:33:51Z-
dc.date.issued2000-
dc.identifier.citationMolecular and Cellular Biochemistry, 2000, v. 207 n. 1-2, p. 143-148-
dc.identifier.issn0300-8177-
dc.identifier.urihttp://hdl.handle.net/10722/224218-
dc.description.abstractAtherosclerosis is the leading cause of death in North America. It is characterized by thickening of the coronary artery wall by the formation of plaques, resulting in reduced blood flow. Plaque rupture and the consequent thrombosis may lead to sudden blockage of arteries and causing stroke and heart attack. In the last several decades, more than 250 factors associated with the development of coronary artery disease have been identified. Recently, a relationship between atherosclerosis and elevated homocysteine level in the blood has been established. The mechanism for the production of atherosclerosis by homocysteine has been investigated. When human hepatoma cells (HepG2) were incubated with 4mM homocysteine, enhancements in the production of cholesterol and secretion of apolipoprotein B-100 were observed. The stimulatory effect on cholesterol synthesis was mediated via the enhancement of HMG-CoA reductase, which catalyzes the rate-limiting step in cholesterol biosynthesis. Cholesterol appears to play an important role in the regulation of apoB-100 secretion by hepatocytes. It is plausible that the increase in apoB secretion was caused by the elevated cholesterol level induced by homocysteine. The ability of homocysteine to produce a higher amount of cholesterol and promote the secretion of apoB would provide a plausible mechanism for the observed relationship between hyperhomocysteinemia and the development of atherogenesis and coronary artery disease.-
dc.languageeng-
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0300-8177-
dc.relation.ispartofMolecular and Cellular Biochemistry-
dc.rightsThe final publication is available at Springer via http://dx.doi.org/[insert DOI]-
dc.subject.meshApolipoproteins B - metabolism-
dc.subject.meshArteriosclerosis - metabolism-
dc.subject.meshCholesterol - metabolism-
dc.subject.meshHomocysteine - physiology-
dc.subject.meshHydroxymethylglutaryl CoA Reductases - metabolism-
dc.titleAtherosclerosis risk factors: The possible role of homocysteine-
dc.typeArticle-
dc.identifier.emailO, K: okarmin@hkucc.hku.hk-
dc.identifier.doi10.1023/A:1017286006708-
dc.identifier.pmid10888240-
dc.identifier.hkuros58415-
dc.identifier.volume207-
dc.identifier.issue1-2-
dc.identifier.spage143-
dc.identifier.epage148-
dc.publisher.placeUnited States-

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