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Article: Protective effect of polysaccharides-enriched fraction from Angelica sinensis on hepatic injury

TitleProtective effect of polysaccharides-enriched fraction from Angelica sinensis on hepatic injury
Authors
Issue Date2001
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
Citation
Life Sciences, 2001, v. 69 n. 6, p. 637-646 How to Cite?
AbstractA polysaccharides-enriched fraction from the root of Angelica sinensis, which is known for its anti-ulcer action on the gastrointestinal tract, was isolated and studied for its hepato-protective effect in rodents. Intra-gastric administration of Angelica sinensis polysaccharides-enriched fraction (AP) at the doses of 50 or 75 mg/kg dose-dependently prevented liver toxicity induced by acetaminophen in mice but did not affect the serum acetaminophen concentration. It normalized the rises of serum alanine transferase (ALT) and hepatic nitric oxide synthase (NOS) activities and the decrease of glutathione level in the liver. It also reduced the hepatic malondialdehyde (MDA) concentration. The protective effect was less evident in the carbon tetrachloride (CCl4)-treated animals including mice and rats. In the rat the elevated serum ALT level was unaffected though the MDA level was similarly reduced by the higher dose of AP. In these animals, CCl4 increased the hepatic glutathione level instead while the NOS activity remained unchanged. These findings suggest that the pathogenic mechanisms of both acetaminophen and CCl4 are different. AP is more effective in the protection against liver damage induced by acetaminophen, which is associated with the glutathione depletion and nitric oxide synthase activation in the liver.
Persistent Identifierhttp://hdl.handle.net/10722/224119
ISSN
2015 Impact Factor: 2.685
2015 SCImago Journal Rankings: 1.056

 

DC FieldValueLanguage
dc.contributor.authorYe, YN-
dc.contributor.authorLiu, ESL-
dc.contributor.authorLi, Y-
dc.contributor.authorSo, HL-
dc.contributor.authorCho, CCM-
dc.contributor.authorSheng, HP-
dc.contributor.authorLee, SS-
dc.contributor.authorCho, CH-
dc.date.accessioned2016-03-24T03:38:05Z-
dc.date.available2016-03-24T03:38:05Z-
dc.date.issued2001-
dc.identifier.citationLife Sciences, 2001, v. 69 n. 6, p. 637-646-
dc.identifier.issn0024-3205-
dc.identifier.urihttp://hdl.handle.net/10722/224119-
dc.description.abstractA polysaccharides-enriched fraction from the root of Angelica sinensis, which is known for its anti-ulcer action on the gastrointestinal tract, was isolated and studied for its hepato-protective effect in rodents. Intra-gastric administration of Angelica sinensis polysaccharides-enriched fraction (AP) at the doses of 50 or 75 mg/kg dose-dependently prevented liver toxicity induced by acetaminophen in mice but did not affect the serum acetaminophen concentration. It normalized the rises of serum alanine transferase (ALT) and hepatic nitric oxide synthase (NOS) activities and the decrease of glutathione level in the liver. It also reduced the hepatic malondialdehyde (MDA) concentration. The protective effect was less evident in the carbon tetrachloride (CCl4)-treated animals including mice and rats. In the rat the elevated serum ALT level was unaffected though the MDA level was similarly reduced by the higher dose of AP. In these animals, CCl4 increased the hepatic glutathione level instead while the NOS activity remained unchanged. These findings suggest that the pathogenic mechanisms of both acetaminophen and CCl4 are different. AP is more effective in the protection against liver damage induced by acetaminophen, which is associated with the glutathione depletion and nitric oxide synthase activation in the liver.-
dc.languageeng-
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie-
dc.relation.ispartofLife Sciences-
dc.rightsPosting accepted manuscript (postprint): © <year>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.subject.meshDrug-Induced Liver Injury - blood - prevention & control-
dc.subject.meshDrugs, Chinese Herbal-
dc.subject.meshPlant Extracts - therapeutic use-
dc.subject.meshPlant Roots - chemistry-
dc.subject.meshRats, Sprague-Dawley-
dc.titleProtective effect of polysaccharides-enriched fraction from Angelica sinensis on hepatic injury-
dc.typeArticle-
dc.identifier.emailSheng, HP: hpsheng@hkucc.hku.hk-
dc.identifier.emailCho, CH: chcho@hkusua.hku.hk-
dc.identifier.doi10.1016/S0024-3205(01)01153-5-
dc.identifier.pmid11476185-
dc.identifier.scopuseid_2-s2.0-0035967847-
dc.identifier.hkuros71779-
dc.identifier.volume69-
dc.identifier.issue6-
dc.identifier.spage637-
dc.identifier.epage646-
dc.publisher.placeUnited States-

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