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Article: Anticancer Activity of Hemsleya Amabilis Extract

TitleAnticancer Activity of Hemsleya Amabilis Extract
Authors
Issue Date2002
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
Citation
Life Sciences, 2002, v. 71 n. 18, p. 2161-2170 How to Cite?
AbstractHemsleya amabilis extract is derived from the medicinal herb Hemsleya amabilis, which has long been used to treat cancer and many other conditions. The underlying mechanism is not clear. To investigate Hemsleya amabili's anticancer activity, we have treated different types of cancer cells including human astrocytoma U87 cells, breast cancer cells MDA-MB-231and Jurkat cells with Hemsleya amabilis extract. This agent significantly inhibited tumor cell growth and colony formation at various concentrations. When astrocytoma cells were seeded in the presence of Hemsleya amabilis extract at very low concentrations, cell spreading was greatly inhibited. Hemsleya amabilis extract also promoted tumor cell death in all the tested cell lines, but with varied sensitivities. Apoptotic assays with Annexin V staining demonstrated that Hemsleya amabilis extract induced astrocytoma cell apoptosis at different concentrations.
Persistent Identifierhttp://hdl.handle.net/10722/224096
ISSN
2015 Impact Factor: 2.685
2015 SCImago Journal Rankings: 1.056

 

DC FieldValueLanguage
dc.contributor.authorWu, J-
dc.contributor.authorWu, Y-
dc.contributor.authorYang, BB-
dc.date.accessioned2016-03-23T07:08:46Z-
dc.date.available2016-03-23T07:08:46Z-
dc.date.issued2002-
dc.identifier.citationLife Sciences, 2002, v. 71 n. 18, p. 2161-2170-
dc.identifier.issn0024-3205-
dc.identifier.urihttp://hdl.handle.net/10722/224096-
dc.description.abstractHemsleya amabilis extract is derived from the medicinal herb Hemsleya amabilis, which has long been used to treat cancer and many other conditions. The underlying mechanism is not clear. To investigate Hemsleya amabili's anticancer activity, we have treated different types of cancer cells including human astrocytoma U87 cells, breast cancer cells MDA-MB-231and Jurkat cells with Hemsleya amabilis extract. This agent significantly inhibited tumor cell growth and colony formation at various concentrations. When astrocytoma cells were seeded in the presence of Hemsleya amabilis extract at very low concentrations, cell spreading was greatly inhibited. Hemsleya amabilis extract also promoted tumor cell death in all the tested cell lines, but with varied sensitivities. Apoptotic assays with Annexin V staining demonstrated that Hemsleya amabilis extract induced astrocytoma cell apoptosis at different concentrations.-
dc.languageeng-
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie-
dc.relation.ispartofLife Sciences-
dc.rightsPosting accepted manuscript (postprint): © <year>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.subject.meshAntineoplastic Agents, Phytogenic - pharmacology-
dc.subject.meshApoptosis - drug effects-
dc.subject.meshCell Survival - drug effects-
dc.subject.meshPlant Extracts - pharmacology-
dc.subject.meshPlants, Medicinal - chemistry-
dc.titleAnticancer Activity of Hemsleya Amabilis Extract-
dc.typeArticle-
dc.identifier.emailWu, J: jwuaa@hkucc.hku.hk-
dc.identifier.doi10.1016/S0024-3205(02)02013-1-
dc.identifier.pmid12204774-
dc.identifier.hkuros106096-
dc.identifier.volume71-
dc.identifier.issue18-
dc.identifier.spage2161-
dc.identifier.epage2170-
dc.publisher.placeUnited States-

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