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Article: An experimental model for studying passive cigarette smoking effects on gastric ulceration

TitleAn experimental model for studying passive cigarette smoking effects on gastric ulceration
Authors
Issue Date1996
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
Citation
Life Sciences, 1996, v. 58 n. 26, p. 2415-2422 How to Cite?
AbstractCigarette smoking is associated with gastric mucosal damage in humans. For this study, a smoke chamber was designed to investigate the effects of passive smoking on gastric ulceration. Different concentrations of cigarette smoke (0%, 1%, 2%, and 4%) were perfused into a chamber for one hr in which conscious rats were placed. This one-hr smoke exposure potentiated ethanol (70%, v/v, p.o.)-induced gastric mucosal damage and increased serum nicotine levels; however, it did not affect the blood pH, pCO2, pO2, and HCO3 concentrations, or the systemic blood pressure and heart rate. Under these experimental conditions, exposure to cigarette smoke produced no significant changes in the blood acid/base balance and stress in the animals but significantly potentiated ethanol-induced gastric mucosal damage. The present experimental model is suitable for studying the adverse interactions between passive smoking and alcohol drinking in gastric ulcer formation in rats.
Persistent Identifierhttp://hdl.handle.net/10722/224095
ISSN
2015 Impact Factor: 2.685
2015 SCImago Journal Rankings: 1.056

 

DC FieldValueLanguage
dc.contributor.authorChow, JYC-
dc.contributor.authorMa, L-
dc.contributor.authorCho, CH-
dc.date.accessioned2016-03-23T06:29:45Z-
dc.date.available2016-03-23T06:29:45Z-
dc.date.issued1996-
dc.identifier.citationLife Sciences, 1996, v. 58 n. 26, p. 2415-2422-
dc.identifier.issn0024-3205-
dc.identifier.urihttp://hdl.handle.net/10722/224095-
dc.description.abstractCigarette smoking is associated with gastric mucosal damage in humans. For this study, a smoke chamber was designed to investigate the effects of passive smoking on gastric ulceration. Different concentrations of cigarette smoke (0%, 1%, 2%, and 4%) were perfused into a chamber for one hr in which conscious rats were placed. This one-hr smoke exposure potentiated ethanol (70%, v/v, p.o.)-induced gastric mucosal damage and increased serum nicotine levels; however, it did not affect the blood pH, pCO2, pO2, and HCO3 concentrations, or the systemic blood pressure and heart rate. Under these experimental conditions, exposure to cigarette smoke produced no significant changes in the blood acid/base balance and stress in the animals but significantly potentiated ethanol-induced gastric mucosal damage. The present experimental model is suitable for studying the adverse interactions between passive smoking and alcohol drinking in gastric ulcer formation in rats.-
dc.languageeng-
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie-
dc.relation.ispartofLife Sciences-
dc.rightsPosting accepted manuscript (postprint): © <year>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.subject.meshRats, Sprague-Dawley-
dc.subject.meshMale-
dc.subject.meshNicotine - blood-
dc.subject.meshStomach Ulcer - etiology-
dc.subject.meshTobacco Smoke Pollution - adverse effects-
dc.titleAn experimental model for studying passive cigarette smoking effects on gastric ulceration-
dc.typeArticle-
dc.identifier.emailCho, CH: chcho@hkusua.hku.hk-
dc.identifier.doi10.1016/0024-3205(96)00245-7-
dc.identifier.pmid8691986-
dc.identifier.hkuros11743-
dc.identifier.volume58-
dc.identifier.issue26-
dc.identifier.spage2415-
dc.identifier.epage2422-
dc.publisher.placeUnited States-

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