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Article: Lycium barbarum polysaccharides promotes in vivo proliferation of adult rat retinal progenitor cells

TitleLycium barbarum polysaccharides promotes in vivo proliferation of adult rat retinal progenitor cells
Authors
Issue Date2015
PublisherMedknow Publications and Media Pvt. Ltd. The Journal's web site is located at http://www.nrronline.org/
Citation
Neural Regeneration Research, 2015, v. 10 n. 12, p. 1976-1981 How to Cite?
AbstractLycium barbarum is a widely used Chinese herbal medicine prescription for protection of optic nerve. However, it remains unclear regarding the effects of Lycium barbarum polysaccharides, the main component of Lycium barbarum, on in vivo proliferation of adult ciliary body cells. In this study, adult rats were intragastrically administered low - and high-dose Lycium barbarum polysaccharides (1 and 10 mg/kg) for 35 days and those intragastrically administered phosphate buffered saline served as controls. The number of ki-67-positive cells in rat ciliary body in the Lycium barbarum polysaccharides groups, in particular low-dose Lycium barbarum polysaccharides group, was significantly greater than that in the phosphate buffered saline group. Ki-67-positive rat ciliary body cells expressed nestin but they did not express glial fibrillary acidic protein. These findings suggest that Lycium barbarum polysaccharides can promote the proliferation of adult rat retinal progenitor cells and the proliferated cells present with neuronal phenotype.
Persistent Identifierhttp://hdl.handle.net/10722/223988
ISSN
2015 Impact Factor: 0.968
2015 SCImago Journal Rankings: 0.337

 

DC FieldValueLanguage
dc.contributor.authorWang, H-
dc.contributor.authorLau, BWM-
dc.contributor.authorWang, NL-
dc.contributor.authorWang, SY-
dc.contributor.authorLu, QJ-
dc.contributor.authorChang, RCC-
dc.contributor.authorSo, KF-
dc.date.accessioned2016-03-18T02:33:22Z-
dc.date.available2016-03-18T02:33:22Z-
dc.date.issued2015-
dc.identifier.citationNeural Regeneration Research, 2015, v. 10 n. 12, p. 1976-1981-
dc.identifier.issn1673-5374-
dc.identifier.urihttp://hdl.handle.net/10722/223988-
dc.description.abstractLycium barbarum is a widely used Chinese herbal medicine prescription for protection of optic nerve. However, it remains unclear regarding the effects of Lycium barbarum polysaccharides, the main component of Lycium barbarum, on in vivo proliferation of adult ciliary body cells. In this study, adult rats were intragastrically administered low - and high-dose Lycium barbarum polysaccharides (1 and 10 mg/kg) for 35 days and those intragastrically administered phosphate buffered saline served as controls. The number of ki-67-positive cells in rat ciliary body in the Lycium barbarum polysaccharides groups, in particular low-dose Lycium barbarum polysaccharides group, was significantly greater than that in the phosphate buffered saline group. Ki-67-positive rat ciliary body cells expressed nestin but they did not express glial fibrillary acidic protein. These findings suggest that Lycium barbarum polysaccharides can promote the proliferation of adult rat retinal progenitor cells and the proliferated cells present with neuronal phenotype.-
dc.languageeng-
dc.publisherMedknow Publications and Media Pvt. Ltd. The Journal's web site is located at http://www.nrronline.org/-
dc.relation.ispartofNeural Regeneration Research-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleLycium barbarum polysaccharides promotes in vivo proliferation of adult rat retinal progenitor cells-
dc.typeArticle-
dc.identifier.emailChang, RCC: rccchang@hku.hk-
dc.identifier.emailSo, KF: hrmaskf@hku.hk-
dc.identifier.authorityChang, RCC=rp00470-
dc.identifier.authoritySo, KF=rp00329-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.4103/1673-5374.172315-
dc.identifier.hkuros257206-
dc.identifier.volume10-
dc.identifier.issue12-
dc.identifier.spage1976-
dc.identifier.epage1981-
dc.publisher.placeChina-

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