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Article: The internal and external responsiveness of Functional Assessment of Cancer Therapy-Prostate (FACT-P) and Short Form-12 Health Survey version 2 (SF-12 v2) in patients with prostate cancer

TitleThe internal and external responsiveness of Functional Assessment of Cancer Therapy-Prostate (FACT-P) and Short Form-12 Health Survey version 2 (SF-12 v2) in patients with prostate cancer
Authors
Issue Date2016
Citation
Quality of Life Research, 2016 How to Cite?
AbstractPurpose: To examine the responsiveness of Functional Assessment of Cancer Therapy-Prostate (FACT-P) and Short Form-12 Health Survey version 2 (SF-12 v2) in prostate cancer patients because there is a lack of evidence to support their responsiveness in prostate cancer patients. Methods: One hundred sixty-eight subjects with prostate cancer were surveyed at baseline and at 6 months using the SF-12 v2 and FACT-P version 4. Internal responsiveness was assessed using paired t test and generalized estimating equation. External responsiveness was evaluated using receiver operating characteristic curve analysis. Results: The internal responsiveness of the FACT-P and SF-12 v2 to detect positive change was satisfactory. The FACT-P and SF-12 v2 could not detect negative change. The FACT-P and the SF-12 v2 performed the best in distinguishing between improved general health and worsened general health. The FACT-P performed better in distinguishing between unchanged general health and worsened general health. The SF-12 v2 performed better in distinguishing between unchanged general health and improved general health. Conclusions: Positive change detected by these measures should be interpreted with caution as they might be too responsive to detect “noise,” which is not clinically significant. The ability of the FACT-P and the SF-12 v2 to detect negative change was disappointing. The internal and external responsiveness of the social well-being of the FACT-P cannot be supported, suggesting that it is not suitable to longitudinally monitor the social component of HRQOL in prostate cancer patients. The study suggested that generic and disease-specific measures should be used together to complement each other.
Persistent Identifierhttp://hdl.handle.net/10722/223856

 

DC FieldValueLanguage
dc.contributor.authorChoi, EPH-
dc.contributor.authorWong, CKH-
dc.contributor.authorWan, EYF-
dc.contributor.authorTsu, HLJ-
dc.contributor.authorChin, WY-
dc.contributor.authorKung, K-
dc.contributor.authorYiu, MK-
dc.date.accessioned2016-03-18T02:30:00Z-
dc.date.available2016-03-18T02:30:00Z-
dc.date.issued2016-
dc.identifier.citationQuality of Life Research, 2016-
dc.identifier.urihttp://hdl.handle.net/10722/223856-
dc.description.abstractPurpose: To examine the responsiveness of Functional Assessment of Cancer Therapy-Prostate (FACT-P) and Short Form-12 Health Survey version 2 (SF-12 v2) in prostate cancer patients because there is a lack of evidence to support their responsiveness in prostate cancer patients. Methods: One hundred sixty-eight subjects with prostate cancer were surveyed at baseline and at 6 months using the SF-12 v2 and FACT-P version 4. Internal responsiveness was assessed using paired t test and generalized estimating equation. External responsiveness was evaluated using receiver operating characteristic curve analysis. Results: The internal responsiveness of the FACT-P and SF-12 v2 to detect positive change was satisfactory. The FACT-P and SF-12 v2 could not detect negative change. The FACT-P and the SF-12 v2 performed the best in distinguishing between improved general health and worsened general health. The FACT-P performed better in distinguishing between unchanged general health and worsened general health. The SF-12 v2 performed better in distinguishing between unchanged general health and improved general health. Conclusions: Positive change detected by these measures should be interpreted with caution as they might be too responsive to detect “noise,” which is not clinically significant. The ability of the FACT-P and the SF-12 v2 to detect negative change was disappointing. The internal and external responsiveness of the social well-being of the FACT-P cannot be supported, suggesting that it is not suitable to longitudinally monitor the social component of HRQOL in prostate cancer patients. The study suggested that generic and disease-specific measures should be used together to complement each other.-
dc.languageeng-
dc.relation.ispartofQuality of Life Research-
dc.titleThe internal and external responsiveness of Functional Assessment of Cancer Therapy-Prostate (FACT-P) and Short Form-12 Health Survey version 2 (SF-12 v2) in patients with prostate cancer-
dc.typeArticle-
dc.identifier.emailChoi, EPH: h0714919@hku.hk-
dc.identifier.emailWong, CKH: carlosho@hku.hk-
dc.identifier.emailWan, EYF: yfwan@hku.hk-
dc.identifier.emailTsu, HLJ: jamestsu@hku.hk-
dc.identifier.emailChin, WY: chinwy@hku.hk-
dc.identifier.emailKung, K: kkung@hku.hk-
dc.identifier.emailYiu, MK: pmkyiu@hku.hk-
dc.identifier.authorityWong, CKH=rp01931-
dc.identifier.authorityChin, WY=rp00290-
dc.identifier.authorityKung, K=rp01974-
dc.identifier.doi10.1007/s11136-016-1254-1-
dc.identifier.hkuros257160-

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