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Conference Paper: Endothelial Dysfunction Is Associated With Decreased Circulating Endothelial Progenitor Cells In Pateints With Systemic Sclerosis

TitleEndothelial Dysfunction Is Associated With Decreased Circulating Endothelial Progenitor Cells In Pateints With Systemic Sclerosis
Authors
Issue Date2009
PublisherBMJ Publishing Group. The Journal's web site is located at http://ard.bmjjournals.com/
Citation
The 2009 ACR/ARHP Annual Scientific Meeting, Philadelphia, PA., 16-21 October 2009. In Annals of the Rheumatic Diseases, 2009, v. 60 n. S10, p. 1710 How to Cite?
AbstractBackground: The role of circulating bone marrow derived endothelial progenitor cells (EPCs) for vascular repair in scleroderma (SSc) remains unclear. Purpose: To examine endothelial dysfunction in SSc patients and to correlate findings with biochemical markers of endothelial injury, circulating EPC count, disease activity and organ involvement. Methods: Endothelial dependent and independent vasodilation responses were assessed by changes in flow mediated dilation (FMD%) and nitroglycerin challenge (NTG%) in the brachial artery respectively in SSc patients compared to age- and sex- matched controls. Serum levels of vascular endothelial growth factor (VEGF) and soluble vascular cell adhesion molecule (sVCAM)-1 were measured by ELISA. Enumeration of circulating CD133/VEGFR2+ EPCs was performed by flow cytometry. Results: Median FMD% (4.8% vs. 7.8%, P<0.001) and NTG% (17.0% vs. 21.4%, P=0.002) were found to be significantly lower in SSc patients (n=52) than controls (n=52), especially in patients with limited disease (lSSc). Median circulating EPC count was significantly lower in lSSc patients (23.0/ml) compared to controls (73.0/ml) (P<0.001). This was accompanied by higher level of sVCAM-1 in these patients compared to those with diffuse disease (P=0.01). Lower circulating EPC count was found to be associated with high disease activity (P=0.04), abnormal forced vital capacity (P=0.003), longer disease duration (P=0.04), total skin score>20 (P=0.03) and lSSc subset (P<0.001). Multivariate analysis identified disease duration as the only independent predictor for circulating EPC count (P=0.04). Conclusion: Endothelial dysfunction was demonstrated in SSc and correlated with biochemical markers of endothelial injury. Lower circulating EPCs might contribute to deficient vascular repair in SSc patients.
Persistent Identifierhttp://hdl.handle.net/10722/223461
ISSN
2015 Impact Factor: 12.384
2015 SCImago Journal Rankings: 4.537

 

DC FieldValueLanguage
dc.contributor.authorMok, TMY-
dc.contributor.authorTse, HF-
dc.contributor.authorLo, Y-
dc.contributor.authorWong, RWS-
dc.contributor.authorLau, WCS-
dc.date.accessioned2016-02-29T03:03:40Z-
dc.date.available2016-02-29T03:03:40Z-
dc.date.issued2009-
dc.identifier.citationThe 2009 ACR/ARHP Annual Scientific Meeting, Philadelphia, PA., 16-21 October 2009. In Annals of the Rheumatic Diseases, 2009, v. 60 n. S10, p. 1710-
dc.identifier.issn0003-4967-
dc.identifier.urihttp://hdl.handle.net/10722/223461-
dc.description.abstractBackground: The role of circulating bone marrow derived endothelial progenitor cells (EPCs) for vascular repair in scleroderma (SSc) remains unclear. Purpose: To examine endothelial dysfunction in SSc patients and to correlate findings with biochemical markers of endothelial injury, circulating EPC count, disease activity and organ involvement. Methods: Endothelial dependent and independent vasodilation responses were assessed by changes in flow mediated dilation (FMD%) and nitroglycerin challenge (NTG%) in the brachial artery respectively in SSc patients compared to age- and sex- matched controls. Serum levels of vascular endothelial growth factor (VEGF) and soluble vascular cell adhesion molecule (sVCAM)-1 were measured by ELISA. Enumeration of circulating CD133/VEGFR2+ EPCs was performed by flow cytometry. Results: Median FMD% (4.8% vs. 7.8%, P<0.001) and NTG% (17.0% vs. 21.4%, P=0.002) were found to be significantly lower in SSc patients (n=52) than controls (n=52), especially in patients with limited disease (lSSc). Median circulating EPC count was significantly lower in lSSc patients (23.0/ml) compared to controls (73.0/ml) (P<0.001). This was accompanied by higher level of sVCAM-1 in these patients compared to those with diffuse disease (P=0.01). Lower circulating EPC count was found to be associated with high disease activity (P=0.04), abnormal forced vital capacity (P=0.003), longer disease duration (P=0.04), total skin score>20 (P=0.03) and lSSc subset (P<0.001). Multivariate analysis identified disease duration as the only independent predictor for circulating EPC count (P=0.04). Conclusion: Endothelial dysfunction was demonstrated in SSc and correlated with biochemical markers of endothelial injury. Lower circulating EPCs might contribute to deficient vascular repair in SSc patients.-
dc.languageeng-
dc.publisherBMJ Publishing Group. The Journal's web site is located at http://ard.bmjjournals.com/-
dc.relation.ispartofAnnals of the Rheumatic Diseases-
dc.rightsAnnals of the Rheumatic Diseases. Copyright © BMJ Publishing Group.-
dc.titleEndothelial Dysfunction Is Associated With Decreased Circulating Endothelial Progenitor Cells In Pateints With Systemic Sclerosis-
dc.typeConference_Paper-
dc.identifier.emailMok, TMY: temy@hkucc.hku.hk-
dc.identifier.emailTse, HF: hftse@hkucc.hku.hk-
dc.identifier.emailLai, KWH: kwhlai@hku.hk-
dc.identifier.emailLo, Y: yloa@HKUCC.hku.hk-
dc.identifier.emailWong, RWS: rwswong@HKUCC.hku.hk-
dc.identifier.emailLau, WCS: cslau@hku.hk-
dc.identifier.authorityMok, TMY=rp00490-
dc.identifier.authorityTse, HF=rp00428-
dc.identifier.authorityLau, WCS=rp01348-
dc.description.natureabstract-
dc.identifier.doi10.1002/art.26784-
dc.identifier.hkuros160321-
dc.identifier.volume60-
dc.identifier.issueS10-
dc.identifier.spage1710-
dc.identifier.epage1710-
dc.publisher.placeUnited Kingdom-

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