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Article: Chemotherapy in pregnancy

TitleChemotherapy in pregnancy
Authors
Issue Date2015
PublisherBailliere Tindall. The Journal's web site is located at http://www.elsevier.com/locate/bpobgyn
Citation
Best Practice & Research: Clinical Obstetrics & Gynaecology, 2015 How to Cite?
AbstractCancer diagnosed during pregnancy is uncommon, complicating between 0.02% and 0.1% of all pregnancies. Nonetheless, due to increasing age of childbearing, the incidence of cancer during pregnancy is likely to increase due to higher incidence of several age-dependent malignancies. The most common malignancies include breast cancer, cervical cancer, malignant melanoma and lymphoma. One of the key challenges in the management of cancer in pregnancy is treating the women with standard chemotherapy regimen, without compromising the safety of the developing foetus. Exposure of chemotherapy in the first trimester is associated with an increased risk of major birth defects, whereas use in the second and third trimesters is associated with intrauterine growth restriction, low birthweight and stillbirth. In this article, we review available data regarding the use of chemotherapeutic agents in pregnancy, and we summarise the neonatal outcomes, including malformations, perinatal complications and long-term follow-up. In addition, the management plan during pregnancy is also discussed.
Persistent Identifierhttp://hdl.handle.net/10722/223263
ISSN
2015 Impact Factor: 2.291
2015 SCImago Journal Rankings: 1.123

 

DC FieldValueLanguage
dc.contributor.authorNgu, SF-
dc.contributor.authorNgan, HYS-
dc.date.accessioned2016-02-23T01:56:20Z-
dc.date.available2016-02-23T01:56:20Z-
dc.date.issued2015-
dc.identifier.citationBest Practice & Research: Clinical Obstetrics & Gynaecology, 2015-
dc.identifier.issn1521-6934-
dc.identifier.urihttp://hdl.handle.net/10722/223263-
dc.description.abstractCancer diagnosed during pregnancy is uncommon, complicating between 0.02% and 0.1% of all pregnancies. Nonetheless, due to increasing age of childbearing, the incidence of cancer during pregnancy is likely to increase due to higher incidence of several age-dependent malignancies. The most common malignancies include breast cancer, cervical cancer, malignant melanoma and lymphoma. One of the key challenges in the management of cancer in pregnancy is treating the women with standard chemotherapy regimen, without compromising the safety of the developing foetus. Exposure of chemotherapy in the first trimester is associated with an increased risk of major birth defects, whereas use in the second and third trimesters is associated with intrauterine growth restriction, low birthweight and stillbirth. In this article, we review available data regarding the use of chemotherapeutic agents in pregnancy, and we summarise the neonatal outcomes, including malformations, perinatal complications and long-term follow-up. In addition, the management plan during pregnancy is also discussed.-
dc.languageeng-
dc.publisherBailliere Tindall. The Journal's web site is located at http://www.elsevier.com/locate/bpobgyn-
dc.relation.ispartofBest Practice & Research: Clinical Obstetrics & Gynaecology-
dc.titleChemotherapy in pregnancy-
dc.typeArticle-
dc.identifier.emailNgu, SF: ngusiewf@hku.hk-
dc.identifier.emailNgan, HYS: hysngan@hkucc.hku.hk-
dc.identifier.authorityNgu, SF=rp01367-
dc.identifier.authorityNgan, HYS=rp00346-
dc.identifier.doi10.1016/j.bpobgyn.2015.10.007-
dc.identifier.pmid26553395-
dc.identifier.hkuros256954-
dc.publisher.placeUnited Kingdom-

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