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Article: Genetic diversity of Aspergillus species isolated from onychomycosis and Aspergillus hongkongensis sp. nov., with implications to antifungal susceptibility testing

TitleGenetic diversity of Aspergillus species isolated from onychomycosis and Aspergillus hongkongensis sp. nov., with implications to antifungal susceptibility testing
Authors
Issue Date2016
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/diagmicrobio
Citation
Diagnostic Microbiology and Infectious Disease, 2016, v. 84 n. 2, p. 125-134 How to Cite?
AbstractThirteen Aspergillus isolates recovered from nails of 13 patients (fingernails, n = 2; toenails, n = 11) with onychomycosis were characterized. Twelve strains were identified by multilocus sequencing as Aspergillus spp. (Aspergillus sydowii [n = 4], Aspergillus welwitschiae [n = 3], Aspergillus terreus [n = 2], Aspergillus flavus [n = 1], Aspergillus tubingensis [n = 1], and Aspergillus unguis [n = 1]). Isolates of A. terreus, A. flavus, and A. unguis were also identifiable by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. The 13th isolate (HKU49T) possessed unique morphological characteristics different from other Aspergillus spp. Molecular characterization also unambiguously showed that HKU49T was distinct from other Aspergillus spp. We propose the novel species Aspergillus hongkongensis to describe this previously unknown fungus. Antifungal susceptibility testing showed most Aspergillus isolates had low MICs against itraconazole and voriconazole, but all Aspergillus isolates had high MICs against fluconazole. A diverse spectrum of Aspergillus species is associated with onychomycosis. Itraconazole and voriconazole are probably better drug options for Aspergillus onychomycosis.
Persistent Identifierhttp://hdl.handle.net/10722/223226
ISSN
2015 Impact Factor: 2.45
2015 SCImago Journal Rankings: 1.142

 

DC FieldValueLanguage
dc.contributor.authorTsang, CC-
dc.contributor.authorHui, TWS-
dc.contributor.authorLee, KC-
dc.contributor.authorChen, JHK-
dc.contributor.authorNgan, AHY-
dc.contributor.authorTam, EWT-
dc.contributor.authorChan, JFW-
dc.contributor.authorWu, AL-
dc.contributor.authorCheung, M-
dc.contributor.authorTse, BPH-
dc.contributor.authorWu, AKL-
dc.contributor.authorLai, CKC-
dc.contributor.authorTsang, DNC-
dc.contributor.authorQue, TL-
dc.contributor.authorLam, CW-
dc.contributor.authorYuen, KY-
dc.contributor.authorLau, SKP-
dc.contributor.authorWoo, PCY-
dc.date.accessioned2016-02-23T01:55:45Z-
dc.date.available2016-02-23T01:55:45Z-
dc.date.issued2016-
dc.identifier.citationDiagnostic Microbiology and Infectious Disease, 2016, v. 84 n. 2, p. 125-134-
dc.identifier.issn0732-8893-
dc.identifier.urihttp://hdl.handle.net/10722/223226-
dc.description.abstractThirteen <i>Aspergillus</i> isolates recovered from nails of 13 patients (fingernails, n = 2; toenails, n = 11) with onychomycosis were characterized. Twelve strains were identified by multilocus sequencing as <i>Aspergillus</i> spp. (<i>Aspergillus sydowii</i> [n = 4], <i>Aspergillus welwitschiae</i> [n = 3], <i>Aspergillus terreus</i> [n = 2], <i>Aspergillus flavus</i> [n = 1], <i>Aspergillus tubingensis</i> [n = 1], and <i>Aspergillus unguis</i> [n = 1]). Isolates of <i>A. terreus</i>, <i>A. flavus</i>, and <i>A. unguis</i> were also identifiable by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. The 13th isolate (HKU49<font size=-1><sup>T</sup></font>) possessed unique morphological characteristics different from other <i>Aspergillus</i> spp. Molecular characterization also unambiguously showed that HKU49<font size=-1><sup>T</sup></font> was distinct from other <i>Aspergillus</i> spp. We propose the novel species <i>Aspergillus hongkongensis</i> to describe this previously unknown fungus. Antifungal susceptibility testing showed most <i>Aspergillus</i> isolates had low MICs against itraconazole and voriconazole, but all <i>Aspergillus</i> isolates had high MICs against fluconazole. A diverse spectrum of <i>Aspergillus</i> species is associated with onychomycosis. Itraconazole and voriconazole are probably better drug options for <i>Aspergillus</i> onychomycosis.-
dc.languageeng-
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/diagmicrobio-
dc.relation.ispartofDiagnostic Microbiology and Infectious Disease-
dc.titleGenetic diversity of Aspergillus species isolated from onychomycosis and Aspergillus hongkongensis sp. nov., with implications to antifungal susceptibility testing-
dc.typeArticle-
dc.identifier.emailChen, JHK: jonchk@hku.hk-
dc.identifier.emailChan, JFW: jfwchan@hku.hk-
dc.identifier.emailWu, AKL: alanklwu@hkucc.hku.hk-
dc.identifier.emailLam, CW: ching-wanlam@pathology.hku.hk-
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hk-
dc.identifier.emailLau, SKP: skplau@hkucc.hku.hk-
dc.identifier.emailWoo, PCY: pcywoo@hkucc.hku.hk-
dc.identifier.authorityChan, JFW=rp01736-
dc.identifier.authorityLam, CW=rp00260-
dc.identifier.authorityYuen, KY=rp00366-
dc.identifier.authorityLau, SKP=rp00486-
dc.identifier.authorityWoo, PCY=rp00430-
dc.identifier.doi10.1016/j.diagmicrobio.2015.10.027-
dc.identifier.pmid26658315-
dc.identifier.hkuros256895-
dc.identifier.volume84-
dc.identifier.issue2-
dc.identifier.spage125-
dc.identifier.epage134-
dc.publisher.placeUnited States-

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