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Article: Polyketides, Toxins and Pigments in Penicillium marneffei

TitlePolyketides, Toxins and Pigments in Penicillium marneffei
Authors
Issue Date2015
PublisherMDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/toxins/
Citation
Toxins, 2015, v. 7 n. 11, p. 4421-4436 How to Cite?
AbstractPenicillium marneffei (synonym: Talaromyces marneffei) is the most important pathogenic thermally dimorphic fungus in China and Southeastern Asia. The HIV/AIDS pandemic, particularly in China and other Southeast Asian countries, has led to the emergence of P. marneffei infection as an important AIDS-defining condition. Recently, we published the genome sequence of P. marneffei. In the P. marneffei genome, 23 polyketide synthase genes and two polyketide synthase-non-ribosomal peptide synthase hybrid genes were identified. This number is much higher than those of Coccidioides immitis and Histoplasma capsulatum, important pathogenic thermally dimorphic fungi in the Western world. Phylogenetically, these polyketide synthase genes were distributed evenly with their counterparts found in Aspergillus species and other fungi, suggesting that polyketide synthases in P. marneffei did not diverge from lineage-specific gene duplication through a recent expansion. Gene knockdown experiments and ultra-high performance liquid chromatography-photodiode array detector/electrospray ionization-quadruple time of flight-mass spectrometry analysis confirmed that at least four of the polyketide synthase genes were involved in the biosynthesis of various pigments in P. marneffei, including melanin, mitorubrinic acid, mitorubrinol, monascorubrin, rubropunctatin, citrinin and ankaflavin, some of which were mycotoxins and virulence factors of the fungus.
Persistent Identifierhttp://hdl.handle.net/10722/223224
ISSN
2015 Impact Factor: 3.571
2015 SCImago Journal Rankings: 0.978
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorTam, EWT-
dc.contributor.authorTsang, CC-
dc.contributor.authorLau, SKP-
dc.contributor.authorWoo, PCY-
dc.date.accessioned2016-02-23T01:55:44Z-
dc.date.available2016-02-23T01:55:44Z-
dc.date.issued2015-
dc.identifier.citationToxins, 2015, v. 7 n. 11, p. 4421-4436-
dc.identifier.issn2072-6651-
dc.identifier.urihttp://hdl.handle.net/10722/223224-
dc.description.abstract<i>Penicillium marneffei</i> (synonym: <i>Talaromyces marneffei</i>) is the most important pathogenic thermally dimorphic fungus in China and Southeastern Asia. The HIV/AIDS pandemic, particularly in China and other Southeast Asian countries, has led to the emergence of P. marneffei infection as an important AIDS-defining condition. Recently, we published the genome sequence of <i>P. marneffei</i>. In the <i>P. marneffei</i> genome, 23 polyketide synthase genes and two polyketide synthase-non-ribosomal peptide synthase hybrid genes were identified. This number is much higher than those of <i>Coccidioides immitis</i> and <i>Histoplasma capsulatum</i>, important pathogenic thermally dimorphic fungi in the Western world. Phylogenetically, these polyketide synthase genes were distributed evenly with their counterparts found in <i>Aspergillus</i> species and other fungi, suggesting that polyketide synthases in <i>P. marneffei</i> did not diverge from lineage-specific gene duplication through a recent expansion. Gene knockdown experiments and ultra-high performance liquid chromatography-photodiode array detector/electrospray ionization-quadruple time of flight-mass spectrometry analysis confirmed that at least four of the polyketide synthase genes were involved in the biosynthesis of various pigments in <i>P. marneffei</i>, including melanin, mitorubrinic acid, mitorubrinol, monascorubrin, rubropunctatin, citrinin and ankaflavin, some of which were mycotoxins and virulence factors of the fungus.-
dc.languageeng-
dc.publisherMDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/toxins/-
dc.relation.ispartofToxins-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titlePolyketides, Toxins and Pigments in Penicillium marneffei-
dc.typeArticle-
dc.identifier.emailLau, SKP: skplau@hkucc.hku.hk-
dc.identifier.emailWoo, PCY: pcywoo@hkucc.hku.hk-
dc.identifier.authorityLau, SKP=rp00486-
dc.identifier.authorityWoo, PCY=rp00430-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3390/toxins7114421-
dc.identifier.pmid26529013-
dc.identifier.pmcidPMC4663511-
dc.identifier.hkuros256893-
dc.identifier.volume7-
dc.identifier.issue11-
dc.identifier.spage4421-
dc.identifier.epage4436-
dc.publisher.placeSwitzerland-

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