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Article: Prospective study on the efficacy of treating normal tension glaucoma with a single session of selective laser trabeculoplasty

TitleProspective study on the efficacy of treating normal tension glaucoma with a single session of selective laser trabeculoplasty
Authors
Issue Date2015
Citation
Journal of glaucoma, 2015, v. 24, n. 1, p. 77-80 How to Cite?
AbstractPURPOSE: The purpose of this study was to investigate the efficacy of selective laser trabeculoplasty (SLT) in the treatment of normal tension glaucoma (NTG). METHODS: This prospective cohort study recruited consecutive cases of NTG on antiglaucoma medication. Cases were excluded for previous glaucoma surgery or laser. All patients underwent a 1-month washout of medication followed by a mean baseline intraocular pressure (IOP) measured at 9 AM, 1 PM, and 5 PM. A 30% reduction from baseline was set as the target IOP. A single session of SLT was performed to 360 degrees of the trabecular meshwork. IOP phasing was repeated at 1 month after SLT and medication was resumed to achieve the target IOP. Patients were followed up to 6 months after SLT. RESULTS: In 83 eyes of 46 subjects, the mean prestudy IOP was 14.2 ± 3.1 mm Hg when on 1.5 ± 0.9 antiglaucoma medication. The mean baseline IOP without medication was 16.1 ± 2.2 mm Hg. The mean SLT shots applied was 187.8 ± 27.5 using a mean energy of 1.0 ± 0.07 mJ. At 1-month post-SLT, the IOP was 12.7 ± 2.0 mm Hg (21.6% IOP reduction) from baseline without medication (P<0.05). The 6-month IOP was 11.4 ± 1.6 mm Hg when on 1.1± 1.0 medications, representing a 19.7% reduction from prestudy IOP, a 29.6% reduction from baseline IOP, and a 26.7% reduction in antiglaucoma medication (all P< 0.05). A higher baseline IOP was correlated with greater IOP reduction with SLT (r=0.3, P=0.009). CONCLUSIONS: A single session of SLT for NTG achieved an additional 20% reduction in IOP with 27% less medication at 6 months compared with prestudy levels while maintaining a 30% reduction from baseline IOP.
Persistent Identifierhttp://hdl.handle.net/10722/222172

 

DC FieldValueLanguage
dc.contributor.authorLee, Jacky W Y-
dc.contributor.authorGangwani, Rita A.-
dc.contributor.authorChan, Jonathan C H-
dc.contributor.authorLai, Jimmy S M-
dc.date.accessioned2015-12-21T06:49:10Z-
dc.date.available2015-12-21T06:49:10Z-
dc.date.issued2015-
dc.identifier.citationJournal of glaucoma, 2015, v. 24, n. 1, p. 77-80-
dc.identifier.urihttp://hdl.handle.net/10722/222172-
dc.description.abstractPURPOSE: The purpose of this study was to investigate the efficacy of selective laser trabeculoplasty (SLT) in the treatment of normal tension glaucoma (NTG). METHODS: This prospective cohort study recruited consecutive cases of NTG on antiglaucoma medication. Cases were excluded for previous glaucoma surgery or laser. All patients underwent a 1-month washout of medication followed by a mean baseline intraocular pressure (IOP) measured at 9 AM, 1 PM, and 5 PM. A 30% reduction from baseline was set as the target IOP. A single session of SLT was performed to 360 degrees of the trabecular meshwork. IOP phasing was repeated at 1 month after SLT and medication was resumed to achieve the target IOP. Patients were followed up to 6 months after SLT. RESULTS: In 83 eyes of 46 subjects, the mean prestudy IOP was 14.2 ± 3.1 mm Hg when on 1.5 ± 0.9 antiglaucoma medication. The mean baseline IOP without medication was 16.1 ± 2.2 mm Hg. The mean SLT shots applied was 187.8 ± 27.5 using a mean energy of 1.0 ± 0.07 mJ. At 1-month post-SLT, the IOP was 12.7 ± 2.0 mm Hg (21.6% IOP reduction) from baseline without medication (P<0.05). The 6-month IOP was 11.4 ± 1.6 mm Hg when on 1.1± 1.0 medications, representing a 19.7% reduction from prestudy IOP, a 29.6% reduction from baseline IOP, and a 26.7% reduction in antiglaucoma medication (all P< 0.05). A higher baseline IOP was correlated with greater IOP reduction with SLT (r=0.3, P=0.009). CONCLUSIONS: A single session of SLT for NTG achieved an additional 20% reduction in IOP with 27% less medication at 6 months compared with prestudy levels while maintaining a 30% reduction from baseline IOP.-
dc.languageeng-
dc.relation.ispartofJournal of glaucoma-
dc.titleProspective study on the efficacy of treating normal tension glaucoma with a single session of selective laser trabeculoplasty-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1097/IJG.0000000000000089-
dc.identifier.pmid25068466-
dc.identifier.scopuseid_2-s2.0-84924922034-
dc.identifier.hkuros234667-
dc.identifier.hkuros264617-
dc.identifier.volume24-
dc.identifier.issue1-
dc.identifier.spage77-
dc.identifier.epage80-
dc.identifier.eissn1536-481X-

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