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Article: Eveningness and insomnia: Independent risk factors of Nonremission in major depressive disorder

TitleEveningness and insomnia: Independent risk factors of Nonremission in major depressive disorder
Authors
KeywordsInsomnia
Depression
Chronotype
Nonremission
Issue Date2014
Citation
Sleep, 2014, v. 37, n. 5, p. 911-917 How to Cite?
AbstractBackground: It is unclear whether there is an association between chronotype and nonremission of depression, and whether the association is related to the confounding effect of insomnia. Method: A cohort of patients with major depressive disorder were assessed for chronotype (by Morningness- Eveningness Questinnaire [MEQ]), depressive symptoms, insomnia severity and clinical outcomes in a naturalistic follow-up study. Results: Of the 253 recruited subjects (age 50.8 ± 10.2 y; female: 82.6%; response rate 90.0%), 19.4%, 56.1% and 24.5% patients were classified as eveningness, intermediate, and morningness, respectively. Evening-type subjects had higher insomnia severity, more severe depressive symptoms, and higher suicidality. Eveningness was associated with nonremission of depression with an odds ratio (OR) of 3.36 (95% confidence interval [CI] 1.35-8.34, P < 0.01), independent of insomnia severity. In addition, insomnia was an independent significant factor in contributing to nonremission of depression (OR = 1.12; 95% CI 1.05-1.19, P < 0.001). Conclusion: The independent association of eveningness with nonremission of depression suggested a significant underpinning of circadian involvement in major depressive disorder. Our findings support the need for a comprehensive assessment of sleep and circadian disturbances as well as integration of sleep and chronotherapeutic intervention in the management of depression.
Persistent Identifierhttp://hdl.handle.net/10722/222157
ISSN
2015 Impact Factor: 4.793
2015 SCImago Journal Rankings: 2.606

 

DC FieldValueLanguage
dc.contributor.authorYan Chan, Joey Wing-
dc.contributor.authorLam, Siu Ping-
dc.contributor.authorLi, Shirley Xin-
dc.contributor.authorMan Yu, Mandy Wai-
dc.contributor.authorChan, Ngan Yin-
dc.contributor.authorZhang, Jihui-
dc.contributor.authorWing, Yun Kwok-
dc.date.accessioned2015-12-21T06:49:03Z-
dc.date.available2015-12-21T06:49:03Z-
dc.date.issued2014-
dc.identifier.citationSleep, 2014, v. 37, n. 5, p. 911-917-
dc.identifier.issn0161-8105-
dc.identifier.urihttp://hdl.handle.net/10722/222157-
dc.description.abstractBackground: It is unclear whether there is an association between chronotype and nonremission of depression, and whether the association is related to the confounding effect of insomnia. Method: A cohort of patients with major depressive disorder were assessed for chronotype (by Morningness- Eveningness Questinnaire [MEQ]), depressive symptoms, insomnia severity and clinical outcomes in a naturalistic follow-up study. Results: Of the 253 recruited subjects (age 50.8 ± 10.2 y; female: 82.6%; response rate 90.0%), 19.4%, 56.1% and 24.5% patients were classified as eveningness, intermediate, and morningness, respectively. Evening-type subjects had higher insomnia severity, more severe depressive symptoms, and higher suicidality. Eveningness was associated with nonremission of depression with an odds ratio (OR) of 3.36 (95% confidence interval [CI] 1.35-8.34, P < 0.01), independent of insomnia severity. In addition, insomnia was an independent significant factor in contributing to nonremission of depression (OR = 1.12; 95% CI 1.05-1.19, P < 0.001). Conclusion: The independent association of eveningness with nonremission of depression suggested a significant underpinning of circadian involvement in major depressive disorder. Our findings support the need for a comprehensive assessment of sleep and circadian disturbances as well as integration of sleep and chronotherapeutic intervention in the management of depression.-
dc.languageeng-
dc.relation.ispartofSleep-
dc.subjectInsomnia-
dc.subjectDepression-
dc.subjectChronotype-
dc.subjectNonremission-
dc.titleEveningness and insomnia: Independent risk factors of Nonremission in major depressive disorder-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.5665/sleep-
dc.identifier.scopuseid_2-s2.0-84899669309-
dc.identifier.volume37-
dc.identifier.issue5-
dc.identifier.spage911-
dc.identifier.epage917-
dc.identifier.eissn1550-9109-

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