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Article: Modulation of potential respiratory pathogens by pH1N1 viral infection

TitleModulation of potential respiratory pathogens by pH1N1 viral infection
Authors
KeywordsMicrobiota
PH1N1
Pneumonia
Cell motility
Chemotaxis
Issue Date2013
Citation
Clinical Microbiology and Infection, 2013, v. 19, n. 10, p. 930-935 How to Cite?
AbstractWhile much effort has been made to characterize influenza A pdm09 virus (pH1N1), the flu that was responsible for the fourth influenza pandemic, there is a lack of study on the composition of bacteria that lead to secondary infection. In this study, we recruited pneumonia patients with and without pH1N1 infection and characterized their oropharyngeal microbiota by the unbiased high-throughput sequencing method. While there were no significant differences in common bacterial pneumonia-causative agents (Acinetobacter and Streptococcus species), previously unreported Pseudomonas species equipped with chemotaxis and flagellar assembly genes significantly increased (>20-fold) in the pH1N1-infected group. Bacillus and Ralstonia species that also increased significantly (5-10-fold) were also found to possess similar signaling and motility genes. In contrast, no such genes were found in oral commensal Prevotella, Veillonella and Neisseria species, which decreased significantly, or in either Acinetobacter or 10 out of 21 Streptococcus species, including Streptococcus pneumoniae. Our results support the notion that pH1N1 infection provides a niche for previously unnoticed potential respiratory pathogens that were able to access the lower respiratory tract with weakened immunity. The Authors Clinical Microbiology and Infection © 2012 European Society of Clinical Microbiology and Infectious Diseases.
Persistent Identifierhttp://hdl.handle.net/10722/222148
ISSN
2015 Impact Factor: 4.575
2015 SCImago Journal Rankings: 2.530

 

DC FieldValueLanguage
dc.contributor.authorLeung, R. K K-
dc.contributor.authorZhou, J. W.-
dc.contributor.authorGuan, W.-
dc.contributor.authorLi, S. K.-
dc.contributor.authorYang, Z. F.-
dc.contributor.authorTsui, S. K W-
dc.date.accessioned2015-12-21T06:48:54Z-
dc.date.available2015-12-21T06:48:54Z-
dc.date.issued2013-
dc.identifier.citationClinical Microbiology and Infection, 2013, v. 19, n. 10, p. 930-935-
dc.identifier.issn1198-743X-
dc.identifier.urihttp://hdl.handle.net/10722/222148-
dc.description.abstractWhile much effort has been made to characterize influenza A pdm09 virus (pH1N1), the flu that was responsible for the fourth influenza pandemic, there is a lack of study on the composition of bacteria that lead to secondary infection. In this study, we recruited pneumonia patients with and without pH1N1 infection and characterized their oropharyngeal microbiota by the unbiased high-throughput sequencing method. While there were no significant differences in common bacterial pneumonia-causative agents (Acinetobacter and Streptococcus species), previously unreported Pseudomonas species equipped with chemotaxis and flagellar assembly genes significantly increased (>20-fold) in the pH1N1-infected group. Bacillus and Ralstonia species that also increased significantly (5-10-fold) were also found to possess similar signaling and motility genes. In contrast, no such genes were found in oral commensal Prevotella, Veillonella and Neisseria species, which decreased significantly, or in either Acinetobacter or 10 out of 21 Streptococcus species, including Streptococcus pneumoniae. Our results support the notion that pH1N1 infection provides a niche for previously unnoticed potential respiratory pathogens that were able to access the lower respiratory tract with weakened immunity. The Authors Clinical Microbiology and Infection © 2012 European Society of Clinical Microbiology and Infectious Diseases.-
dc.languageeng-
dc.relation.ispartofClinical Microbiology and Infection-
dc.subjectMicrobiota-
dc.subjectPH1N1-
dc.subjectPneumonia-
dc.subjectCell motility-
dc.subjectChemotaxis-
dc.titleModulation of potential respiratory pathogens by pH1N1 viral infection-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1111/1469-0691.12054-
dc.identifier.pmid23167452-
dc.identifier.scopuseid_2-s2.0-84884713908-
dc.identifier.volume19-
dc.identifier.issue10-
dc.identifier.spage930-
dc.identifier.epage935-
dc.identifier.eissn1469-0691-

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