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postgraduate thesis: The effect of neoadjuvant radiotherapy on colorectal cancer : a systematic review

TitleThe effect of neoadjuvant radiotherapy on colorectal cancer : a systematic review
Authors
Issue Date2015
PublisherThe University of Hong Kong (Pokfulam, Hong Kong)
Citation
Wong, H. [黃凱烽]. (2015). The effect of neoadjuvant radiotherapy on colorectal cancer : a systematic review. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5662877
AbstractBackground: Colorectal cancer is one of the common form of cancer in Hong Kong. Neoadjuvant radiotherapy is used to reduce the size of the tumour to achieve better treatment outcome. Previous studies on reducing local recurrence are positive, but improvement in survival still remains controversial. Study Objective: To systematically review the effect of neoadjuvant radiotherapy for patients with colorectal cancer. Method: Systematic review of relevant Randomised Controlled Trials (RCT) using electronic databases PubMed and Cochrane Library. The articles were retrieved through a screening process by hand. RCTs that have compared the effect of neoadjuvant radiotherapy on patients’ survival were included. Data were extracted and pooled for analysis. Results: Nine RCTs were included in this review. The characteristics of the trials, the patients of each trial, treatment assignments, effect of treatment and the quality of each trial were summarised. Benefit in survival cannot be seen in patients assigned to radiotherapy compared to the surgery only group. Conclusion: Neoadjuvant radiotherapy do not show a beneficial effect on patients with colorectal cancer. This result shows consistency with previous studies. Despite a potential benefit in local recurrence, the lack of evidence of survival improvement places the treatment in a less preferred position. Decision analysis should be performed to carefully weight out the cost, adverse effect from the treatment and its benefit.
DegreeMaster of Public Health
SubjectColon (Anatomy) - Cancer - Radiotherapy
Rectum - Cancer - Radiotherapy
Dept/ProgramPublic Health
Persistent Identifierhttp://hdl.handle.net/10722/221865

 

DC FieldValueLanguage
dc.contributor.authorWong, Hoi-fung-
dc.contributor.author黃凱烽-
dc.date.accessioned2015-12-16T23:18:20Z-
dc.date.available2015-12-16T23:18:20Z-
dc.date.issued2015-
dc.identifier.citationWong, H. [黃凱烽]. (2015). The effect of neoadjuvant radiotherapy on colorectal cancer : a systematic review. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5662877-
dc.identifier.urihttp://hdl.handle.net/10722/221865-
dc.description.abstractBackground: Colorectal cancer is one of the common form of cancer in Hong Kong. Neoadjuvant radiotherapy is used to reduce the size of the tumour to achieve better treatment outcome. Previous studies on reducing local recurrence are positive, but improvement in survival still remains controversial. Study Objective: To systematically review the effect of neoadjuvant radiotherapy for patients with colorectal cancer. Method: Systematic review of relevant Randomised Controlled Trials (RCT) using electronic databases PubMed and Cochrane Library. The articles were retrieved through a screening process by hand. RCTs that have compared the effect of neoadjuvant radiotherapy on patients’ survival were included. Data were extracted and pooled for analysis. Results: Nine RCTs were included in this review. The characteristics of the trials, the patients of each trial, treatment assignments, effect of treatment and the quality of each trial were summarised. Benefit in survival cannot be seen in patients assigned to radiotherapy compared to the surgery only group. Conclusion: Neoadjuvant radiotherapy do not show a beneficial effect on patients with colorectal cancer. This result shows consistency with previous studies. Despite a potential benefit in local recurrence, the lack of evidence of survival improvement places the treatment in a less preferred position. Decision analysis should be performed to carefully weight out the cost, adverse effect from the treatment and its benefit.-
dc.languageeng-
dc.publisherThe University of Hong Kong (Pokfulam, Hong Kong)-
dc.relation.ispartofHKU Theses Online (HKUTO)-
dc.rightsThe author retains all proprietary rights, (such as patent rights) and the right to use in future works.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.lcshColon (Anatomy) - Cancer - Radiotherapy-
dc.subject.lcshRectum - Cancer - Radiotherapy-
dc.titleThe effect of neoadjuvant radiotherapy on colorectal cancer : a systematic review-
dc.typePG_Thesis-
dc.identifier.hkulb5662877-
dc.description.thesisnameMaster of Public Health-
dc.description.thesislevelMaster-
dc.description.thesisdisciplinePublic Health-
dc.description.naturepublished_or_final_version-

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