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Article: Viral evolution explains the associations among hepatitis C virus genotype, clinical outcomes, and human genetic variation

TitleViral evolution explains the associations among hepatitis C virus genotype, clinical outcomes, and human genetic variation
Authors
KeywordsCo-evolution
Hepatitis C virus
Phylogeny
SNPs
IFNL3
Issue Date2013
PublisherElsevier BV.
Citation
Infection Genetics and Evolution, 2013, v. 20, p. 418-421 How to Cite?
AbstractSpecific human polymorphisms, most commonly found in Central Africa, can predict the success of drug treatment against the hepatitis C virus (HCV), a significant and globally-distributed human pathogen. However, this association is only found for a subset of HCV genotypes. Despite receiving considerable attention in the medical and virological literature, no evolutionary explanation for this curious pattern has been put forward. Here we suggest that the ‘drug treatment resistance’ phenotype exhibited today by some HCV genotypes evolved hundreds to thousands of years ago in response to human genetic variation local to Central Africa: an adaptation that has since accrued a new function in the era of anti-viral drug treatment. This could represent one of the oldest known examples of viral exaptation at the population level.
Persistent Identifierhttp://hdl.handle.net/10722/221827
ISSN
2015 Impact Factor: 2.591
2015 SCImago Journal Rankings: 1.431
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorRose, R-
dc.contributor.authorMarkov, PV-
dc.contributor.authorLam, TY-
dc.contributor.authorPybus, OG-
dc.date.accessioned2015-12-10T04:03:54Z-
dc.date.available2015-12-10T04:03:54Z-
dc.date.issued2013-
dc.identifier.citationInfection Genetics and Evolution, 2013, v. 20, p. 418-421-
dc.identifier.issn1567-1348-
dc.identifier.urihttp://hdl.handle.net/10722/221827-
dc.description.abstractSpecific human polymorphisms, most commonly found in Central Africa, can predict the success of drug treatment against the hepatitis C virus (HCV), a significant and globally-distributed human pathogen. However, this association is only found for a subset of HCV genotypes. Despite receiving considerable attention in the medical and virological literature, no evolutionary explanation for this curious pattern has been put forward. Here we suggest that the ‘drug treatment resistance’ phenotype exhibited today by some HCV genotypes evolved hundreds to thousands of years ago in response to human genetic variation local to Central Africa: an adaptation that has since accrued a new function in the era of anti-viral drug treatment. This could represent one of the oldest known examples of viral exaptation at the population level.-
dc.languageeng-
dc.publisherElsevier BV.-
dc.relation.ispartofInfection Genetics and Evolution-
dc.rights© <2013>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.subjectCo-evolution-
dc.subjectHepatitis C virus-
dc.subjectPhylogeny-
dc.subjectSNPs-
dc.subjectIFNL3-
dc.titleViral evolution explains the associations among hepatitis C virus genotype, clinical outcomes, and human genetic variation-
dc.typeArticle-
dc.identifier.emailLam, TY: ttylam@hku.hk-
dc.identifier.authorityLam, TY=rp01733-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.meegid.2013.09.029-
dc.identifier.volume20-
dc.identifier.spage418-
dc.identifier.epage421-
dc.identifier.isiWOS:000327701200053-
dc.publisher.placeNetherlands-

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