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Conference Paper: Influenza: An idea model bridging epidemiological and evolutionary dynamics

TitleInfluenza: An idea model bridging epidemiological and evolutionary dynamics
Authors
KeywordsInfluenza
Co-circulation
Predator-prey model
Epidemiological dynamics
Evolutionary dynamics
Issue Date2008
PublisherElsevier BV.
Citation
The 8th International Congress of Molecular Epidemiology and Evolutionary Genetics of Infectious Diseases, Bangkok, Thailand, 30 November-2 December 2006. In Infection Genetics and Evolution, 2008, v. 8 n. 4, p. S10-S11 How to Cite?
AbstractAnnual outbreaks of influenza cause substantial morbidity and mortality, and also cause heavy economic losses. In recent years the threat of a human influenza pandemic has increased considerably as humans have become susceptible to infection by the avian influenza virus H5N1. However, our current understanding of influenza and the ability to evaluate the threat are limited. Several important issues, including the influence of climate variability on influenza epidemic patterns and intraspecific and interspecific interactions between various circulating influenza types, subtypes and strains, have not yet been sufficiently studied. In this study, we explored the immunological dynamics and epidemiological dynamics of influenza using our host immune unit-virus-susceptible (HVS) model. By matching model output to epidemiological patterns identified in surveillance data collected from United States, we found that three types of interspecific competitions (between influenza A and B, influenza A subtypes H1 and H3, and new and circulating strains) are essential to depict phylogenetic patterns of influenza. The study therefore, illustrates the population dynamics of the emergence, circulation and elimination of new influenza variants (subtypes or strains).
Persistent Identifierhttp://hdl.handle.net/10722/221820
ISSN
2015 Impact Factor: 2.591
2015 SCImago Journal Rankings: 1.431
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWang, Z-
dc.contributor.authorHon, CC-
dc.contributor.authorLam, TY-
dc.contributor.authorZeng, F-
dc.contributor.authorLeung, FCC-
dc.date.accessioned2015-12-10T01:57:18Z-
dc.date.available2015-12-10T01:57:18Z-
dc.date.issued2008-
dc.identifier.citationThe 8th International Congress of Molecular Epidemiology and Evolutionary Genetics of Infectious Diseases, Bangkok, Thailand, 30 November-2 December 2006. In Infection Genetics and Evolution, 2008, v. 8 n. 4, p. S10-S11-
dc.identifier.issn1567-1348-
dc.identifier.urihttp://hdl.handle.net/10722/221820-
dc.description.abstractAnnual outbreaks of influenza cause substantial morbidity and mortality, and also cause heavy economic losses. In recent years the threat of a human influenza pandemic has increased considerably as humans have become susceptible to infection by the avian influenza virus H5N1. However, our current understanding of influenza and the ability to evaluate the threat are limited. Several important issues, including the influence of climate variability on influenza epidemic patterns and intraspecific and interspecific interactions between various circulating influenza types, subtypes and strains, have not yet been sufficiently studied. In this study, we explored the immunological dynamics and epidemiological dynamics of influenza using our host immune unit-virus-susceptible (HVS) model. By matching model output to epidemiological patterns identified in surveillance data collected from United States, we found that three types of interspecific competitions (between influenza A and B, influenza A subtypes H1 and H3, and new and circulating strains) are essential to depict phylogenetic patterns of influenza. The study therefore, illustrates the population dynamics of the emergence, circulation and elimination of new influenza variants (subtypes or strains).-
dc.languageeng-
dc.publisherElsevier BV.-
dc.relation.ispartofInfection Genetics and Evolution-
dc.rights© <2008>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.subjectInfluenza-
dc.subjectCo-circulation-
dc.subjectPredator-prey model-
dc.subjectEpidemiological dynamics-
dc.subjectEvolutionary dynamics-
dc.titleInfluenza: An idea model bridging epidemiological and evolutionary dynamics-
dc.typeConference_Paper-
dc.identifier.emailLam, TY: ttylam@hku.hk-
dc.identifier.emailLeung, FCC: fcleung@hkucc.hku.hk-
dc.identifier.authorityLam, TY=rp01733-
dc.identifier.authorityLeung, FCC=rp00731-
dc.description.natureabstract-
dc.identifier.doi10.1016/j.meegid.2008.01.008-
dc.identifier.volume8-
dc.identifier.issue4-
dc.identifier.spageS10-
dc.identifier.epageS11-
dc.identifier.isiWOS:000257001400040-
dc.publisher.placeThe Netherlands-

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