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Article: Durability of small-for-size living donor allografts

TitleDurability of small-for-size living donor allografts
Authors
Issue Date2015
Citation
Liver Transplantation, 2015, v. 21, n. 11, p. 1374-1382 How to Cite?
Abstract© 2015 AASLD. © 2015 American Association for the Study of Liver Diseases. Our aim was to study the long-term outcomes of living donor liver transplantation using small-for-size (SFS) grafts. From July 2002 to July 2009, 233 patients received a right liver graft with a middle hepatic vein from a living donor in our center. Recipients were stratified according to the graft weight to recipient standard liver volume (GW/SLV) ratio into 4 groups: >50% (n = 89), >40% to 50% (n = 85), >35% to 40% (n = 38), and ≤35% (n = 21). They were compared in terms of graft survivals, biliary stricture rates, renal function in terms of estimated glomerular filtration rate (eGFR), platelet counts, and graft function in terms of serum bilirubin and international normalized ratio (INR). The 5-year graft survivals for patients with GW/SLV of >50%, >40% to 50%, >35% to 40% and ≤35% were 88.8%, 88.2%, 81.5%, and 81.0%, respectively. Transplantation for hepatocellular carcinoma affected graft survivals (P = 0.02), but graft size did not (P = 0.66). There were no differences in frequency of biliary stricture (21.3% versus 17.1% versus 21.1% versus 28.6%; P = 0.75). At each year after transplant, their platelet counts (P = 0.12-0.65), eGFR (P = 0.49-0.91), bilirubin (P = 0.14-0.51), and INR (P = 0.20-0.98) remained comparable. SFS grafts with GW/SLV ≤35% and >35% to 40% had comparable long-term outcomes with larger liver grafts. Graft size did not affect long-term graft survivals. Liver Transpl 21:1374-1382, 2015.
Persistent Identifierhttp://hdl.handle.net/10722/221395
ISSN
2015 Impact Factor: 3.951
2015 SCImago Journal Rankings: 1.763

 

DC FieldValueLanguage
dc.contributor.authorAu, KP-
dc.contributor.authorChan, SC-
dc.contributor.authorChok, KSH-
dc.contributor.authorChan, ACY-
dc.contributor.authorWong, TCL-
dc.contributor.authorSharr, WW-
dc.contributor.authorLo, CM-
dc.date.accessioned2015-11-18T06:09:12Z-
dc.date.available2015-11-18T06:09:12Z-
dc.date.issued2015-
dc.identifier.citationLiver Transplantation, 2015, v. 21, n. 11, p. 1374-1382-
dc.identifier.issn1527-6465-
dc.identifier.urihttp://hdl.handle.net/10722/221395-
dc.description.abstract© 2015 AASLD. © 2015 American Association for the Study of Liver Diseases. Our aim was to study the long-term outcomes of living donor liver transplantation using small-for-size (SFS) grafts. From July 2002 to July 2009, 233 patients received a right liver graft with a middle hepatic vein from a living donor in our center. Recipients were stratified according to the graft weight to recipient standard liver volume (GW/SLV) ratio into 4 groups: >50% (n = 89), >40% to 50% (n = 85), >35% to 40% (n = 38), and ≤35% (n = 21). They were compared in terms of graft survivals, biliary stricture rates, renal function in terms of estimated glomerular filtration rate (eGFR), platelet counts, and graft function in terms of serum bilirubin and international normalized ratio (INR). The 5-year graft survivals for patients with GW/SLV of >50%, >40% to 50%, >35% to 40% and ≤35% were 88.8%, 88.2%, 81.5%, and 81.0%, respectively. Transplantation for hepatocellular carcinoma affected graft survivals (P = 0.02), but graft size did not (P = 0.66). There were no differences in frequency of biliary stricture (21.3% versus 17.1% versus 21.1% versus 28.6%; P = 0.75). At each year after transplant, their platelet counts (P = 0.12-0.65), eGFR (P = 0.49-0.91), bilirubin (P = 0.14-0.51), and INR (P = 0.20-0.98) remained comparable. SFS grafts with GW/SLV ≤35% and >35% to 40% had comparable long-term outcomes with larger liver grafts. Graft size did not affect long-term graft survivals. Liver Transpl 21:1374-1382, 2015.-
dc.languageeng-
dc.relation.ispartofLiver Transplantation-
dc.titleDurability of small-for-size living donor allografts-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1002/lt.24205-
dc.identifier.scopuseid_2-s2.0-84945892716-
dc.identifier.hkuros250854-
dc.identifier.volume21-
dc.identifier.issue11-
dc.identifier.spage1374-
dc.identifier.epage1382-
dc.identifier.eissn1527-6473-

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