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Conference Paper: Outcomes of hepatectomy for hepatocellular carcinoma with bile duct tumour thrombus

TitleOutcomes of hepatectomy for hepatocellular carcinoma with bile duct tumour thrombus
Authors
Issue Date2015
Citation
HPB, 2015, v. 17, n. 5, p. 401-408 How to Cite?
AbstractBackground Hepatocellular carcinoma (HCC) with bile duct tumour thrombus (BDTT) is rare. The aim of the present study was to determine the prognosis of HCC with BDTT after a hepatectomy. Methods A retrospective analysis was performed on all HCC patients with BDTT having a hepatectomy from 1989 to 2012. The outcomes in these patients were compared with those in the control patients matched on a 1:6 ratio. Results Thirty-seven HCC patients with BDTT having a hepatectomy (the BDTT group) were compared with 222 control patients. Patients in the BDTT group had poorer liver function (43.2% had Child-Pugh B disease). More patients in this group had a major hepatectomy (91.9% versus 27.5%, P = 0.001), portal vein resection (10.8% versus 1.4%, P = 0.006), en-bloc resection with adjacent structures (16.2% versus 5.4%, P = 0.041), hepaticojejunostomy (75.7% versus 1.6%, P < 0.001) and complications (51.4% versus 31.1%, P = 0.016). The two groups had similar hospital mortality (2.7% versus 5.0%, P = 0.856), 5-year overall survival (38.5% versus 34.6%, P = 0.59) and 5-year disease-free survival (21.1% versus 20.8%, P = 0.81). Multivariate analysis showed that lymphovascular permeation, tumour size and post-operative complication were significant predictors for worse survival whereas BDTT was not. Discussion A major hepatectomy, extrahepatic biliary resection and hepaticojejunostomy should be the standard for HCC with BDTT, and long-term survival is possible after radical surgery.
Persistent Identifierhttp://hdl.handle.net/10722/221378
ISSN
2015 Impact Factor: 2.918
2015 SCImago Journal Rankings: 1.586

 

DC FieldValueLanguage
dc.contributor.authorWong, TCL-
dc.contributor.authorCheung, TT-
dc.contributor.authorChok, KSH-
dc.contributor.authorChan, ACY-
dc.contributor.authorDai, WC-
dc.contributor.authorChan, SC-
dc.contributor.authorPoon, RTP-
dc.contributor.authorFan, ST-
dc.contributor.authorLo, CM-
dc.date.accessioned2015-11-18T06:09:09Z-
dc.date.available2015-11-18T06:09:09Z-
dc.date.issued2015-
dc.identifier.citationHPB, 2015, v. 17, n. 5, p. 401-408-
dc.identifier.issn1365-182X-
dc.identifier.urihttp://hdl.handle.net/10722/221378-
dc.description.abstractBackground Hepatocellular carcinoma (HCC) with bile duct tumour thrombus (BDTT) is rare. The aim of the present study was to determine the prognosis of HCC with BDTT after a hepatectomy. Methods A retrospective analysis was performed on all HCC patients with BDTT having a hepatectomy from 1989 to 2012. The outcomes in these patients were compared with those in the control patients matched on a 1:6 ratio. Results Thirty-seven HCC patients with BDTT having a hepatectomy (the BDTT group) were compared with 222 control patients. Patients in the BDTT group had poorer liver function (43.2% had Child-Pugh B disease). More patients in this group had a major hepatectomy (91.9% versus 27.5%, P = 0.001), portal vein resection (10.8% versus 1.4%, P = 0.006), en-bloc resection with adjacent structures (16.2% versus 5.4%, P = 0.041), hepaticojejunostomy (75.7% versus 1.6%, P < 0.001) and complications (51.4% versus 31.1%, P = 0.016). The two groups had similar hospital mortality (2.7% versus 5.0%, P = 0.856), 5-year overall survival (38.5% versus 34.6%, P = 0.59) and 5-year disease-free survival (21.1% versus 20.8%, P = 0.81). Multivariate analysis showed that lymphovascular permeation, tumour size and post-operative complication were significant predictors for worse survival whereas BDTT was not. Discussion A major hepatectomy, extrahepatic biliary resection and hepaticojejunostomy should be the standard for HCC with BDTT, and long-term survival is possible after radical surgery.-
dc.languageeng-
dc.relation.ispartofHPB-
dc.titleOutcomes of hepatectomy for hepatocellular carcinoma with bile duct tumour thrombus-
dc.typeConference_Paper-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1111/hpb.12368-
dc.identifier.scopuseid_2-s2.0-84927515203-
dc.identifier.hkuros241968-
dc.identifier.volume17-
dc.identifier.issue5-
dc.identifier.spage401-
dc.identifier.epage408-
dc.identifier.eissn1477-2574-

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