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Article: Analysis of long-term survival after hepatectomy for isolated liver metastasis of gastrointestinal stromal tumour

TitleAnalysis of long-term survival after hepatectomy for isolated liver metastasis of gastrointestinal stromal tumour
Authors
KeywordsLiver resection
TKI
GIST
Tyrosine-kinase inhibitor
Liver metastasis
Issue Date2013
Citation
ANZ Journal of Surgery, 2013 How to Cite?
AbstractBackground: In the treatment of liver metastasis of gastrointestinal stromal tumour (GIST), the role of hepatectomy is controversial. This study tried to identify such role by investigating the immediate and long-term surgical outcomes. Methods: Data of patients who underwent hepatectomy to treat their metastatic disease were reviewed. Patients whose liver tumours were confirmed to be metastatic GISTs were included for analysis. Clinicopathological characteristics of the primary disease, time of metastasis development and modes of treatment were recorded. Immediate outcome and long-term survival after hepatectomy were analysed. Results: Ten patients were confirmed to have isolated liver metastasis of GIST. Their median age was 61 (42-74) years. All of them had normal liver function and no cirrhosis. Seven patients received major hepatectomy and three patients received minor hepatectomy. The median operation time was 319.5 (122-735)min. The median tumor size was 5.5 (1.5-15) cm. No hospital death occurred. The 1-, 3- and 5-year overall survival rates were 100, 75 and 50%, respectively and the corresponding disease-free survival rates were 70, 42 and 14%, respectively. Conclusion: Treating isolated liver metastasis of GIST with hepatectomy is effective and safe. Favourable long-term overall survival and disease-free survival can be achieved. © 2013 Royal Australasian College of Surgeons.
Persistent Identifierhttp://hdl.handle.net/10722/221341
ISSN
2015 Impact Factor: 1.158
2015 SCImago Journal Rankings: 0.432

 

DC FieldValueLanguage
dc.contributor.authorCheung, TT-
dc.contributor.authorChok, KSH-
dc.contributor.authorChan, ACY-
dc.contributor.authorYau, TCC-
dc.contributor.authorChan, SC-
dc.contributor.authorPoon, RTP-
dc.contributor.authorFan, ST-
dc.contributor.authorLo, CM-
dc.date.accessioned2015-11-18T06:09:03Z-
dc.date.available2015-11-18T06:09:03Z-
dc.date.issued2013-
dc.identifier.citationANZ Journal of Surgery, 2013-
dc.identifier.issn1445-1433-
dc.identifier.urihttp://hdl.handle.net/10722/221341-
dc.description.abstractBackground: In the treatment of liver metastasis of gastrointestinal stromal tumour (GIST), the role of hepatectomy is controversial. This study tried to identify such role by investigating the immediate and long-term surgical outcomes. Methods: Data of patients who underwent hepatectomy to treat their metastatic disease were reviewed. Patients whose liver tumours were confirmed to be metastatic GISTs were included for analysis. Clinicopathological characteristics of the primary disease, time of metastasis development and modes of treatment were recorded. Immediate outcome and long-term survival after hepatectomy were analysed. Results: Ten patients were confirmed to have isolated liver metastasis of GIST. Their median age was 61 (42-74) years. All of them had normal liver function and no cirrhosis. Seven patients received major hepatectomy and three patients received minor hepatectomy. The median operation time was 319.5 (122-735)min. The median tumor size was 5.5 (1.5-15) cm. No hospital death occurred. The 1-, 3- and 5-year overall survival rates were 100, 75 and 50%, respectively and the corresponding disease-free survival rates were 70, 42 and 14%, respectively. Conclusion: Treating isolated liver metastasis of GIST with hepatectomy is effective and safe. Favourable long-term overall survival and disease-free survival can be achieved. © 2013 Royal Australasian College of Surgeons.-
dc.languageeng-
dc.relation.ispartofANZ Journal of Surgery-
dc.subjectLiver resection-
dc.subjectTKI-
dc.subjectGIST-
dc.subjectTyrosine-kinase inhibitor-
dc.subjectLiver metastasis-
dc.titleAnalysis of long-term survival after hepatectomy for isolated liver metastasis of gastrointestinal stromal tumour-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1111/ans.12249-
dc.identifier.scopuseid_2-s2.0-84879060408-
dc.identifier.hkuros216960-
dc.identifier.eissn1445-2197-

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