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Article: Multistep DNA-Templated Synthesis Using a Universal Template

TitleMultistep DNA-Templated Synthesis Using a Universal Template
Authors
Issue Date2013
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/jacsat/index.html
Citation
Journal of the American Chemical Society, 2013, v. 135 n. 47, p. 17727-17730 How to Cite?
AbstractWe report a DNA-templated synthesis method that allows construction of the entire DNA-encoded library with a single DNA template. Taking advantage of deoxyinosine's indiscriminate base-pairing property, we designed a 'universal template' that is capable of directing chemical reactions with multiple reactant DNAs with different sequences. In combination with other design features including photocleavable linkers and direct encoding by the reactant DNA, we demonstrated the capabilities of the universal template in library synthesis, target selection, and hit decoding. Our method can be generally and straightforwardly applied to prepare a variety of chemically diverse DNA-encoded libraries. © 2013 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/221119
ISSN
2015 Impact Factor: 13.038
2015 SCImago Journal Rankings: 7.123
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, Y-
dc.contributor.authorZhao, P-
dc.contributor.authorZhang, M-
dc.contributor.authorZhao, X-
dc.contributor.authorLi, X-
dc.date.accessioned2015-10-27T09:08:02Z-
dc.date.available2015-10-27T09:08:02Z-
dc.date.issued2013-
dc.identifier.citationJournal of the American Chemical Society, 2013, v. 135 n. 47, p. 17727-17730-
dc.identifier.issn0002-7863-
dc.identifier.urihttp://hdl.handle.net/10722/221119-
dc.description.abstractWe report a DNA-templated synthesis method that allows construction of the entire DNA-encoded library with a single DNA template. Taking advantage of deoxyinosine's indiscriminate base-pairing property, we designed a 'universal template' that is capable of directing chemical reactions with multiple reactant DNAs with different sequences. In combination with other design features including photocleavable linkers and direct encoding by the reactant DNA, we demonstrated the capabilities of the universal template in library synthesis, target selection, and hit decoding. Our method can be generally and straightforwardly applied to prepare a variety of chemically diverse DNA-encoded libraries. © 2013 American Chemical Society.-
dc.languageeng-
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/jacsat/index.html-
dc.relation.ispartofJournal of the American Chemical Society-
dc.titleMultistep DNA-Templated Synthesis Using a Universal Template-
dc.typeArticle-
dc.identifier.emailLi, X: xiaoyuli@hku.hk-
dc.identifier.authorityLi, X=rp02080-
dc.identifier.doi10.1021/ja409936r-
dc.identifier.pmid24229415-
dc.identifier.scopuseid_2-s2.0-84889241150-
dc.identifier.volume135-
dc.identifier.issue47-
dc.identifier.spage17727-
dc.identifier.epage17730-
dc.identifier.isiWOS:000328099400019-
dc.publisher.placeUnited States-

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