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Article: Facile solid-phase synthesis of PNA–peptide conjugates using pNZ-protected PNA monomers

TitleFacile solid-phase synthesis of PNA–peptide conjugates using pNZ-protected PNA monomers
Authors
Issue Date2014
PublisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/journals-books-databases/about-journals/organic-chemistry-frontiers/
Citation
Organic Chemistry Frontiers: an international journal of organic chemistry, 2014, v. 1 n. 9, p. 1050-1054 How to Cite?
AbstractPNA-peptide conjugates are useful molecular tools in chemical biology and biotechnology. Although several approaches have been developed to synthesize PNA-peptide conjugates, more efficient methods are still needed. In this report a new pNZ (p-nitrobenzyloxycarbonyl)/bis-Boc strategy was developed as an alternative backbone/nucleobase protecting group method. The mild deprotection conditions of pNZ group and pNZ's full orthogonality with Fmoc solid-phase synthesis enable a new dimension of synthetic flexibility and practicality to generate versatile PNA-peptide conjugates. © 2014 the Partner Organisations.
Persistent Identifierhttp://hdl.handle.net/10722/221114
ISSN
2015 SCImago Journal Rankings: 2.436

 

DC FieldValueLanguage
dc.contributor.authorHuang, YC-
dc.contributor.authorCao, C-
dc.contributor.authorTan, XL-
dc.contributor.authorLi, X-
dc.contributor.authorLiu, L-
dc.date.accessioned2015-10-27T08:20:44Z-
dc.date.available2015-10-27T08:20:44Z-
dc.date.issued2014-
dc.identifier.citationOrganic Chemistry Frontiers: an international journal of organic chemistry, 2014, v. 1 n. 9, p. 1050-1054-
dc.identifier.issn2052-4110-
dc.identifier.urihttp://hdl.handle.net/10722/221114-
dc.description.abstractPNA-peptide conjugates are useful molecular tools in chemical biology and biotechnology. Although several approaches have been developed to synthesize PNA-peptide conjugates, more efficient methods are still needed. In this report a new pNZ (p-nitrobenzyloxycarbonyl)/bis-Boc strategy was developed as an alternative backbone/nucleobase protecting group method. The mild deprotection conditions of pNZ group and pNZ's full orthogonality with Fmoc solid-phase synthesis enable a new dimension of synthetic flexibility and practicality to generate versatile PNA-peptide conjugates. © 2014 the Partner Organisations.-
dc.languageeng-
dc.publisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/journals-books-databases/about-journals/organic-chemistry-frontiers/-
dc.relation.ispartofOrganic Chemistry Frontiers: an international journal of organic chemistry-
dc.titleFacile solid-phase synthesis of PNA–peptide conjugates using pNZ-protected PNA monomers-
dc.typeArticle-
dc.identifier.emailLi, X: xiaoyuli@hku.hk-
dc.identifier.authorityLi, X=rp02080-
dc.identifier.doi10.1039/C4QO00217B-
dc.identifier.scopuseid_2-s2.0-84939504803-
dc.identifier.volume1-
dc.identifier.issue9-
dc.identifier.spage1050-
dc.identifier.epage1054-
dc.publisher.placeUnited Kingdom-

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