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Article: Maldevelopment Of Spinal Cord--Substance P In Spina Bifida.

TitleMaldevelopment Of Spinal Cord--Substance P In Spina Bifida.
Authors
Issue Date1986
Citation
Zeitschrift Fur Kinderchirurgie : Organ Der Deutschen, Der Schweizerischen Und Der Osterreichischen Gesellschaft Fur Kinderchirurgie = Surgery In Infancy And Childhood, 1986, v. 41 n. 4, p. 206-208 How to Cite?
AbstractRecent Works Have Shown That The Neuropeptide, Substance P, Is An Important Element Of The Central Nervous System, Functioning As A Neurotransmitter As Well As Moderating Neural Development. In A Previous Communication, We Provided Indirect Evidence That Substance P Played A Role In The Pathogenesis And Pathophysiology Of Spina Bifida By Showing An Elevation Of Csf Substance P Concentrations In Affected Foetuses And Babies. In This Study, We Investigated Directly The Occurrence Of Substance P In Spinal Cord Tissues In Spina Bifida And Compared It To That Found During Normal Development. Using Radioimmunoassay, Concentrations Of Substance P Were Measured In The Spinal Cords Of 20 Normal Human Foetuses (Aged 9-21 Weeks) And 4 Foetuses With Spina Bifida (Aged 17-19 Weeks). Substance P Was Detected In Substantial Amounts In The Normal Foetal Spinal Cord As Early As 9 Weeks' Gestation, And There Was Progressive Accumulation With Age: Mean Concentrations +/- S.E.M. In 3 Subgroups Were 56.3 +/- 4.9 Pmol G-1 (9-12 Weeks), 59.5 +/- 7.2 Pmol G-1 (13-16 Weeks) And 117.3 +/- 7.2 Pmol G-1 (17-21 Weeks). In Spina Bifida, Substance P Was Severely Depleted In The Dysraphic Segment Of The Cord (Mean Concentration +/- S.E.M. = 22.1 +/- 2.3 Pmol G-1) And Moderately So In The Segment Above The Dysraphism (Mean Concentration +/- S.E.M. = 47.2 +/- 4.2 Pmol G-1).(Abstract Truncated At 250 Words)
Persistent Identifierhttp://hdl.handle.net/10722/220831
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTam, PKHen_US
dc.contributor.authorLister, Jen_US
dc.date.accessioned2015-10-19T07:18:55Z-
dc.date.available2015-10-19T07:18:55Z-
dc.date.issued1986-
dc.identifier.citationZeitschrift Fur Kinderchirurgie : Organ Der Deutschen, Der Schweizerischen Und Der Osterreichischen Gesellschaft Fur Kinderchirurgie = Surgery In Infancy And Childhood, 1986, v. 41 n. 4, p. 206-208en_US
dc.identifier.issn0174-3082-
dc.identifier.urihttp://hdl.handle.net/10722/220831-
dc.description.abstractRecent Works Have Shown That The Neuropeptide, Substance P, Is An Important Element Of The Central Nervous System, Functioning As A Neurotransmitter As Well As Moderating Neural Development. In A Previous Communication, We Provided Indirect Evidence That Substance P Played A Role In The Pathogenesis And Pathophysiology Of Spina Bifida By Showing An Elevation Of Csf Substance P Concentrations In Affected Foetuses And Babies. In This Study, We Investigated Directly The Occurrence Of Substance P In Spinal Cord Tissues In Spina Bifida And Compared It To That Found During Normal Development. Using Radioimmunoassay, Concentrations Of Substance P Were Measured In The Spinal Cords Of 20 Normal Human Foetuses (Aged 9-21 Weeks) And 4 Foetuses With Spina Bifida (Aged 17-19 Weeks). Substance P Was Detected In Substantial Amounts In The Normal Foetal Spinal Cord As Early As 9 Weeks' Gestation, And There Was Progressive Accumulation With Age: Mean Concentrations +/- S.E.M. In 3 Subgroups Were 56.3 +/- 4.9 Pmol G-1 (9-12 Weeks), 59.5 +/- 7.2 Pmol G-1 (13-16 Weeks) And 117.3 +/- 7.2 Pmol G-1 (17-21 Weeks). In Spina Bifida, Substance P Was Severely Depleted In The Dysraphic Segment Of The Cord (Mean Concentration +/- S.E.M. = 22.1 +/- 2.3 Pmol G-1) And Moderately So In The Segment Above The Dysraphism (Mean Concentration +/- S.E.M. = 47.2 +/- 4.2 Pmol G-1).(Abstract Truncated At 250 Words)en_US
dc.languageengen_US
dc.relation.ispartofZeitschrift Fur Kinderchirurgie : Organ Der Deutschen, Der Schweizerischen Und Der Osterreichischen Gesellschaft Fur Kinderchirurgie = Surgery In Infancy And Childhooden_US
dc.titleMaldevelopment Of Spinal Cord--Substance P In Spina Bifida.en_US
dc.typeArticleen_US
dc.identifier.emailTam, PKH:paultam@hkucc.hku.hk-
dc.identifier.authorityTam, PKH=rp00060-
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid2429475-
dc.identifier.scopuseid_2-s2.0-0022764235-
dc.identifier.volume41-
dc.identifier.issue4-
dc.identifier.spage206-
dc.identifier.epage208-
dc.identifier.isiWOS:A1986D727500003-

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