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Article: New Insights Into Peptidergic Abnormalities In Hirschsprung's Disease By Wholemount Immunohistochemistry

TitleNew Insights Into Peptidergic Abnormalities In Hirschsprung's Disease By Wholemount Immunohistochemistry
Authors
Issue Date1991
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/jpedsurg
Citation
Journal Of Pediatric Surgery, 1991, v. 26 n. 5, p. 595-597 How to Cite?
AbstractIn A Pilot Study Previously Reported, We Showed That Individual Nerves Could Be Traced In The Different Layers Of The Gut In Hirschsprung's Disease (Hd) Using Wholemount Immunohistochemistry (Wi). Little Is Known About The Course Of The Important Nonadrenergic, Noncholinergic Nerves Containing Neuropeptides In Hd. Therefore, We Studied The Distribution Of Neuropeptides In 9 Hd Patients And 5 Controls Using Wi. The New Findings Include The Following: (1) There Were Two Populations Of Substance P (Sp) Nerves-In Aganglionic Gut, Sp-Efferent Nerves Were Decreased But Sp-Afferent Fibres Innervating Blood Vessels And Mucosa Remained Unchanged; (2) Met-Enkephin Was Present Only In Efferent Nerves To Muscle And Was Decreased In Aganglionic Gut; And (3) Peptidergic Nerves Have A Disorganised Pattern In Hd Affecting Not Only Aganglionic Gut But Also 'Normal' Gut At The Colostomy Site. These Peptidergic Abnormalities May Play An Important Role In The Pathophysiology Of Hd. In Particular, The Imbalance Of Afferent And Efferent Innervation, A Finding Not Previously Described In Hd, Warrants Special Attention In Future Studies.
Persistent Identifierhttp://hdl.handle.net/10722/220800
ISSN
2015 Impact Factor: 1.733
2015 SCImago Journal Rankings: 0.802
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTam, PKHen_US
dc.contributor.authorBoyd, GPen_US
dc.date.accessioned2015-10-19T03:53:35Z-
dc.date.available2015-10-19T03:53:35Z-
dc.date.issued1991-
dc.identifier.citationJournal Of Pediatric Surgery, 1991, v. 26 n. 5, p. 595-597en_US
dc.identifier.issn0022-3468-
dc.identifier.urihttp://hdl.handle.net/10722/220800-
dc.description.abstractIn A Pilot Study Previously Reported, We Showed That Individual Nerves Could Be Traced In The Different Layers Of The Gut In Hirschsprung's Disease (Hd) Using Wholemount Immunohistochemistry (Wi). Little Is Known About The Course Of The Important Nonadrenergic, Noncholinergic Nerves Containing Neuropeptides In Hd. Therefore, We Studied The Distribution Of Neuropeptides In 9 Hd Patients And 5 Controls Using Wi. The New Findings Include The Following: (1) There Were Two Populations Of Substance P (Sp) Nerves-In Aganglionic Gut, Sp-Efferent Nerves Were Decreased But Sp-Afferent Fibres Innervating Blood Vessels And Mucosa Remained Unchanged; (2) Met-Enkephin Was Present Only In Efferent Nerves To Muscle And Was Decreased In Aganglionic Gut; And (3) Peptidergic Nerves Have A Disorganised Pattern In Hd Affecting Not Only Aganglionic Gut But Also 'Normal' Gut At The Colostomy Site. These Peptidergic Abnormalities May Play An Important Role In The Pathophysiology Of Hd. In Particular, The Imbalance Of Afferent And Efferent Innervation, A Finding Not Previously Described In Hd, Warrants Special Attention In Future Studies.en_US
dc.languageengen_US
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/jpedsurgen_US
dc.relation.ispartofJournal Of Pediatric Surgeryen_US
dc.titleNew Insights Into Peptidergic Abnormalities In Hirschsprung's Disease By Wholemount Immunohistochemistryen_US
dc.typeArticleen_US
dc.identifier.emailTam, PKH:paultam@hkucc.hku.hk-
dc.identifier.authorityTam, PKH=rp00060-
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0022-3468(91)90715-6-
dc.identifier.pmid1712036-
dc.identifier.scopuseid_2-s2.0-0025865648-
dc.identifier.volume26-
dc.identifier.issue5-
dc.identifier.spage595-
dc.identifier.epage597-
dc.identifier.isiWOS:A1991FL02600022-

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