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Article: Abnormalities In The Distribution Of Laminin And Collagen Type Iv In Hirschsprung's Disease

TitleAbnormalities In The Distribution Of Laminin And Collagen Type Iv In Hirschsprung's Disease
Authors
Issue Date1992
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/gastro
Citation
Gastroenterology, 1992, v. 102 n. 4, p. 1236-1241 How to Cite?
AbstractIn Vitro Neurite Outgrowth And Neuronal Survival Are Promoted By Laminin, And Neuronal Migration Is Promoted By Collagen Type Iv. This Led To The Hypothesis That Hirschsprung's Disease (Hd) Could Be The Result Of An Abnormal Extracellular Matrix Microenvironment In The Affected Bowel During Embryogenesis. Using Indirect Immunohistochemistry, We Studied The Distribution Of Laminin And Collagen Type Iv In The Bowel Specimens Of Eight Hd Patients (Four Neonates And Four Infants) And 16 Age- And Site-Matched Controls From Non-Hd Patients. In Eight Hd Specimens, The Tissue Studied Was From The Aganglionic, Transitional, And Proximal Normoganglionic Zones. Uniform Distribution Of Laminin And Collagen Type Iv Was Observed In The Basement Membranes Of All Control Specimens. The Semiquantitative Abnormality In The Distribution Of These Proteins In Hd Occurred As Follows: Immunoreactivities Were More Intense In The Inner Circular Layer, Diminishing With A Gradient In The Outer Muscularis Externa In Six Of Six Aganglionic, Four Of Five Transitional, And Three Of Eight Normoganglionic Sections. The Qualitative Abnormality Of These Proteins In Hd Was Speckled Immunofluorescence Outside The Basement Membranes Of The Muscularis Externa In All Three Zones Of Neonatal Specimens Only. These Findings Support The Microenvironment Hypothesis Of The Pathogenesis Of Hd.
Persistent Identifierhttp://hdl.handle.net/10722/220798
ISSN
2015 Impact Factor: 18.187
2015 SCImago Journal Rankings: 7.170
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorParikh, DHen_US
dc.contributor.authorTam, PKHen_US
dc.contributor.authorVan Velzen, Den_US
dc.contributor.authorEdgar, Den_US
dc.date.accessioned2015-10-19T03:51:40Z-
dc.date.available2015-10-19T03:51:40Z-
dc.date.issued1992-
dc.identifier.citationGastroenterology, 1992, v. 102 n. 4, p. 1236-1241en_US
dc.identifier.issn0016-5085-
dc.identifier.urihttp://hdl.handle.net/10722/220798-
dc.description.abstractIn Vitro Neurite Outgrowth And Neuronal Survival Are Promoted By Laminin, And Neuronal Migration Is Promoted By Collagen Type Iv. This Led To The Hypothesis That Hirschsprung's Disease (Hd) Could Be The Result Of An Abnormal Extracellular Matrix Microenvironment In The Affected Bowel During Embryogenesis. Using Indirect Immunohistochemistry, We Studied The Distribution Of Laminin And Collagen Type Iv In The Bowel Specimens Of Eight Hd Patients (Four Neonates And Four Infants) And 16 Age- And Site-Matched Controls From Non-Hd Patients. In Eight Hd Specimens, The Tissue Studied Was From The Aganglionic, Transitional, And Proximal Normoganglionic Zones. Uniform Distribution Of Laminin And Collagen Type Iv Was Observed In The Basement Membranes Of All Control Specimens. The Semiquantitative Abnormality In The Distribution Of These Proteins In Hd Occurred As Follows: Immunoreactivities Were More Intense In The Inner Circular Layer, Diminishing With A Gradient In The Outer Muscularis Externa In Six Of Six Aganglionic, Four Of Five Transitional, And Three Of Eight Normoganglionic Sections. The Qualitative Abnormality Of These Proteins In Hd Was Speckled Immunofluorescence Outside The Basement Membranes Of The Muscularis Externa In All Three Zones Of Neonatal Specimens Only. These Findings Support The Microenvironment Hypothesis Of The Pathogenesis Of Hd.en_US
dc.languageengen_US
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/gastroen_US
dc.relation.ispartofGastroenterologyen_US
dc.titleAbnormalities In The Distribution Of Laminin And Collagen Type Iv In Hirschsprung's Diseaseen_US
dc.typeArticleen_US
dc.identifier.emailTam, PKH:paultam@hkucc.hku.hk-
dc.identifier.authorityTam, PKH=rp00060-
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid1551530-
dc.identifier.scopuseid_2-s2.0-0026516299-
dc.identifier.volume102-
dc.identifier.issue4-
dc.identifier.spage1236-
dc.identifier.epage1241-
dc.identifier.isiWOS:A1992HK97600018-

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