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Article: Abnormal Expression And Distribution Of Nidogen In Hirschsprung's Disease

TitleAbnormal Expression And Distribution Of Nidogen In Hirschsprung's Disease
Authors
Issue Date1995
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/jpedsurg
Citation
Journal Of Pediatric Surgery, 1995, v. 30 n. 12, p. 1687-1693 How to Cite?
AbstractHirschsprung's Disease (Congenital Colonic Aganglionosis) Is Associated With Abnormalities In The Distributions And Amounts Of Basement Membrane And Other Extracellular Matrix Components In The Human Gut. The Authors Have Investigated The Possible Significance Of Nidogen In Hirschsprung's Disease, Because This Glycoprotein Is Necessary For The Formation Of Ternary Complexes With The Other Basement Membrane Components, Laminin And Collagen Type Iv, And Thus May Contribute The Pathology Of The Disease. Increased Nidogen Immunoreactivity In The Smooth Muscle Basement Membranes And Muscularis Mucosae Of The Distal Aganglionic Zone In Hirschsprung's Bowel Was Observed, The Nidogen Immunoreactivity Demonstrating That The Thickness Of The Muscularis Mucosae Was Increased In This Region. However, Steady-State Nidogen Mrna Levels Were Found To Be Significantly Lower In Both Proximal And Distal Hirschsprung's Bowel (Relative To Controls). In Contrast, No Significant Differences Were Observed In The Steady-State Levels Of The Mrnas Coding For Laminin Subunits. These Results Indicate That Although Abnormalities In The Amount Or Distribution Of Nidogen May Contribute To The Abnormalities Seen In The Extracellular Matrix In Hirschsprung's Disease, The Levels Of Expression Of The Genes Coding For Either Nidogen Or Laminin Are Unlikely To Be Primarily Responsible For The Lesions.
Persistent Identifierhttp://hdl.handle.net/10722/220779
ISSN
2015 Impact Factor: 1.733
2015 SCImago Journal Rankings: 0.802
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorParikh, DHen_US
dc.contributor.authorLeibl, Men_US
dc.contributor.authorTam, PKHen_US
dc.contributor.authorEdgar, Den_US
dc.date.accessioned2015-10-19T03:32:36Z-
dc.date.available2015-10-19T03:32:36Z-
dc.date.issued1995-
dc.identifier.citationJournal Of Pediatric Surgery, 1995, v. 30 n. 12, p. 1687-1693en_US
dc.identifier.issn0022-3468-
dc.identifier.urihttp://hdl.handle.net/10722/220779-
dc.description.abstractHirschsprung's Disease (Congenital Colonic Aganglionosis) Is Associated With Abnormalities In The Distributions And Amounts Of Basement Membrane And Other Extracellular Matrix Components In The Human Gut. The Authors Have Investigated The Possible Significance Of Nidogen In Hirschsprung's Disease, Because This Glycoprotein Is Necessary For The Formation Of Ternary Complexes With The Other Basement Membrane Components, Laminin And Collagen Type Iv, And Thus May Contribute The Pathology Of The Disease. Increased Nidogen Immunoreactivity In The Smooth Muscle Basement Membranes And Muscularis Mucosae Of The Distal Aganglionic Zone In Hirschsprung's Bowel Was Observed, The Nidogen Immunoreactivity Demonstrating That The Thickness Of The Muscularis Mucosae Was Increased In This Region. However, Steady-State Nidogen Mrna Levels Were Found To Be Significantly Lower In Both Proximal And Distal Hirschsprung's Bowel (Relative To Controls). In Contrast, No Significant Differences Were Observed In The Steady-State Levels Of The Mrnas Coding For Laminin Subunits. These Results Indicate That Although Abnormalities In The Amount Or Distribution Of Nidogen May Contribute To The Abnormalities Seen In The Extracellular Matrix In Hirschsprung's Disease, The Levels Of Expression Of The Genes Coding For Either Nidogen Or Laminin Are Unlikely To Be Primarily Responsible For The Lesions.en_US
dc.languageengen_US
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/jpedsurgen_US
dc.relation.ispartofJournal Of Pediatric Surgeryen_US
dc.titleAbnormal Expression And Distribution Of Nidogen In Hirschsprung's Diseaseen_US
dc.typeArticleen_US
dc.identifier.emailTam, PKH:paultam@hkucc.hku.hk-
dc.identifier.authorityTam, PKH=rp00060-
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid8749925-
dc.identifier.scopuseid_2-s2.0-0028856735-
dc.identifier.volume30-
dc.identifier.issue12-
dc.identifier.spage1687-
dc.identifier.epage1693-
dc.identifier.isiWOS:A1995TK76500014-

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