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Conference Paper: Does cervical disc arthroplasty reduce adjacent segment disease and other complications in comparison to anterior cervical discectomy and fusion? A meta-analysis of randomized controlled trials

TitleDoes cervical disc arthroplasty reduce adjacent segment disease and other complications in comparison to anterior cervical discectomy and fusion? A meta-analysis of randomized controlled trials
Authors
Issue Date2012
PublisherGeorg Thieme Verlag.
Citation
The World Forum for Spine Research (WSR 2012): The Intervertebral Disc - from Degeneration to Pain, Helsinki, Finland, 18-21 June 2012. In Global Spine Journal, 2012, v. 2 suppl. 1, abstract P146 How to Cite?
AbstractINTRODUCTION: To reduce the risk of adjacent segment disease and other procedure-related complications following anterior cervical discectomy and fusion (ACDF), cervical disk arthroplasty (CDA) has been advocated for one-level cervical disk disease. However, it remains unknown whether CDA decreases the occurrence of such complications. As such, the following study addressed a meta-analysis of randomized controlled trials assessing the efficacy of CDA in reducing adjacent segment disease and other complications in comparison to ACDF. MATERIALS AND METHODS: Three reviewers performed a literature search for randomized controlled trials comparing CDA to ACDF for radiculopathy and/or myelopathy for one-level cervical disk disease. Studies with 2 years or greater follow-up were selected. Adjacent segment disease, secondary surgery (i.e., revision, reoperation, instrumentation/graft removal), and adverse events were assessed and pooled for analyses. RESULTS: Eight studies were included for review. Due to limitations with study design, studies presented with Level II evidence. CDA exhibited a decrease risk for reoperation attributed to adjacent segment disease, but was not statistically significant (p > 0.05). Additional procedure-related complications did not statistically differ between groups (p > 0.05). CONCLUSION: Up to 4-year follow-up, CDA does not significantly reduce the risk of adjacent segment disease and other complications in comparison to ACDF. Due to the lack of blinding, variation in surgical management and relatively high withdrawal/drop-out rates among studies at 2 and 4 year follow-up, robust conclusions supporting the advocacy of CDA over ACDF cannot be made at this stage. High-quality studies are needed to properly assess the true efficacy of such interventions.
DescriptionThis free journal suppl. contain congress abstracts of WSR 2012
Persistent Identifierhttp://hdl.handle.net/10722/220391
ISSN
2015 SCImago Journal Rankings: 0.108

 

DC FieldValueLanguage
dc.contributor.authorSamartzis, D-
dc.contributor.authorVavken, P-
dc.contributor.authorModi, HN-
dc.contributor.authorLuk, K-
dc.contributor.authorCheung, K-
dc.date.accessioned2015-10-16T06:40:43Z-
dc.date.available2015-10-16T06:40:43Z-
dc.date.issued2012-
dc.identifier.citationThe World Forum for Spine Research (WSR 2012): The Intervertebral Disc - from Degeneration to Pain, Helsinki, Finland, 18-21 June 2012. In Global Spine Journal, 2012, v. 2 suppl. 1, abstract P146-
dc.identifier.issn2192-5682-
dc.identifier.urihttp://hdl.handle.net/10722/220391-
dc.descriptionThis free journal suppl. contain congress abstracts of WSR 2012-
dc.description.abstractINTRODUCTION: To reduce the risk of adjacent segment disease and other procedure-related complications following anterior cervical discectomy and fusion (ACDF), cervical disk arthroplasty (CDA) has been advocated for one-level cervical disk disease. However, it remains unknown whether CDA decreases the occurrence of such complications. As such, the following study addressed a meta-analysis of randomized controlled trials assessing the efficacy of CDA in reducing adjacent segment disease and other complications in comparison to ACDF. MATERIALS AND METHODS: Three reviewers performed a literature search for randomized controlled trials comparing CDA to ACDF for radiculopathy and/or myelopathy for one-level cervical disk disease. Studies with 2 years or greater follow-up were selected. Adjacent segment disease, secondary surgery (i.e., revision, reoperation, instrumentation/graft removal), and adverse events were assessed and pooled for analyses. RESULTS: Eight studies were included for review. Due to limitations with study design, studies presented with Level II evidence. CDA exhibited a decrease risk for reoperation attributed to adjacent segment disease, but was not statistically significant (p > 0.05). Additional procedure-related complications did not statistically differ between groups (p > 0.05). CONCLUSION: Up to 4-year follow-up, CDA does not significantly reduce the risk of adjacent segment disease and other complications in comparison to ACDF. Due to the lack of blinding, variation in surgical management and relatively high withdrawal/drop-out rates among studies at 2 and 4 year follow-up, robust conclusions supporting the advocacy of CDA over ACDF cannot be made at this stage. High-quality studies are needed to properly assess the true efficacy of such interventions.-
dc.languageeng-
dc.publisherGeorg Thieme Verlag.-
dc.relation.ispartofGlobal Spine Journal-
dc.rightsGlobal Spine Journal. Copyright © Georg Thieme Verlag.-
dc.titleDoes cervical disc arthroplasty reduce adjacent segment disease and other complications in comparison to anterior cervical discectomy and fusion? A meta-analysis of randomized controlled trials-
dc.typeConference_Paper-
dc.identifier.emailSamartzis, D: dspine@hku.hk-
dc.identifier.emailLuk, K: hrmoldk@hkucc.hku.hk-
dc.identifier.emailCheung, K: cheungmc@hku.hk-
dc.identifier.authoritySamartzis, D=rp01430-
dc.identifier.authorityLuk, K=rp00333-
dc.identifier.authorityCheung, K=rp00387-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1055/s-0032-1320007-
dc.identifier.hkuros255937-
dc.identifier.volume2-
dc.identifier.issuesuppl. 1-
dc.publisher.placeGermany-
dc.customcontrol.immutablesml 151209-

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