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Conference Paper: Small-molecule suppressors of proteoglycan catabolism in degenerative disc cells

TitleSmall-molecule suppressors of proteoglycan catabolism in degenerative disc cells
Authors
Issue Date2015
Citation
The 61st Annual Meeting of the Orthopaedic Research Society (ORS 2015), Las Vegas, NV., 28-31 March 2015. How to Cite?
AbstractINTRODUCTION: Proteoglycans (PGs) occupy the predominant extracellular matrix (ECM) components in cartilages and intervertebral discs (IVDs). Large numbers of compositional glycosaminoglycans (GAGs) render PG highly hydrophilic for providing water retention capacity and swelling pressure to the connective tissues to neutralize the axial mechanical loads [1]. Its loss of content is tightly associated with the tissue degeneration. In the intervertebral disc degeneration (IDD), a reduction of PGs in central gelatinous nucleus pulposus (NP) was characterized as the first event, which consequently leads to a replacement of fibrocartilaginous ...
Persistent Identifierhttp://hdl.handle.net/10722/220258

 

DC FieldValueLanguage
dc.contributor.authorSun, Y-
dc.contributor.authorMasuda, K-
dc.contributor.authorChan, D-
dc.contributor.authorCheung, K-
dc.contributor.authorLeung, V-
dc.date.accessioned2015-10-16T06:34:03Z-
dc.date.available2015-10-16T06:34:03Z-
dc.date.issued2015-
dc.identifier.citationThe 61st Annual Meeting of the Orthopaedic Research Society (ORS 2015), Las Vegas, NV., 28-31 March 2015.-
dc.identifier.urihttp://hdl.handle.net/10722/220258-
dc.description.abstractINTRODUCTION: Proteoglycans (PGs) occupy the predominant extracellular matrix (ECM) components in cartilages and intervertebral discs (IVDs). Large numbers of compositional glycosaminoglycans (GAGs) render PG highly hydrophilic for providing water retention capacity and swelling pressure to the connective tissues to neutralize the axial mechanical loads [1]. Its loss of content is tightly associated with the tissue degeneration. In the intervertebral disc degeneration (IDD), a reduction of PGs in central gelatinous nucleus pulposus (NP) was characterized as the first event, which consequently leads to a replacement of fibrocartilaginous ...-
dc.languageeng-
dc.relation.ispartofAnnual Meeting of Orthopaedic Research Society, ORS 2015-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleSmall-molecule suppressors of proteoglycan catabolism in degenerative disc cells-
dc.typeConference_Paper-
dc.identifier.emailChan, D: chand@hku.hk-
dc.identifier.emailCheung, K: cheungmc@hku.hk-
dc.identifier.emailLeung, V: vicleung@hku.hk-
dc.identifier.authorityChan, D=rp00540-
dc.identifier.authorityCheung, K=rp00387-
dc.identifier.authorityLeung, V=rp01764-
dc.description.naturepostprint-
dc.identifier.hkuros256068-

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