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Conference Paper: Evaluation of glutamatergic metabolism and its role in neurovascular coupling by combined proton magnetic resonance spectroscopy and pseudo-continuous arterial spin labeling in aging

TitleEvaluation of glutamatergic metabolism and its role in neurovascular coupling by combined proton magnetic resonance spectroscopy and pseudo-continuous arterial spin labeling in aging
Authors
Issue Date2015
Citation
The 23rd Annual Meeting & Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM) & SMRT 24th Annual Meeting, Toronto, ON., Canada, 30-31 May 2015. How to Cite?
AbstractIn this study, we evaluated the age-related change in glutamatergic metabolism and its role in neurovascular coupling via quantitiave proton magnetic resonance spectroscopy and pseudo-continuous arterial spin labeling in anterior cingulate cortex (ACC). Glutamine concentration was found to increase with age, whereas as both global and regional cerebral blood flow (CBF) in ACC showed age-related decline. However, no direct relationship was found between CBF and glutamatergic synaptic activity in aging suggesting the age-related alteration in glutamatergic metabolism might not directly affect CBF.
DescriptionTraditional Poster Session • MR Spectroscopy, Spectroscopic & Non-Proton Imaging, ESR - MRS Normal & Ageing Brain: no. 2006
Persistent Identifierhttp://hdl.handle.net/10722/220244

 

DC FieldValueLanguage
dc.contributor.authorChiu, PW-
dc.contributor.authorLiu, P-
dc.contributor.authorChan, Q-
dc.contributor.authorChang, RCC-
dc.contributor.authorChu, LW-
dc.contributor.authorLu, H-
dc.contributor.authorMak, HKF-
dc.date.accessioned2015-10-16T06:33:31Z-
dc.date.available2015-10-16T06:33:31Z-
dc.date.issued2015-
dc.identifier.citationThe 23rd Annual Meeting & Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM) & SMRT 24th Annual Meeting, Toronto, ON., Canada, 30-31 May 2015.-
dc.identifier.urihttp://hdl.handle.net/10722/220244-
dc.descriptionTraditional Poster Session • MR Spectroscopy, Spectroscopic & Non-Proton Imaging, ESR - MRS Normal & Ageing Brain: no. 2006-
dc.description.abstractIn this study, we evaluated the age-related change in glutamatergic metabolism and its role in neurovascular coupling via quantitiave proton magnetic resonance spectroscopy and pseudo-continuous arterial spin labeling in anterior cingulate cortex (ACC). Glutamine concentration was found to increase with age, whereas as both global and regional cerebral blood flow (CBF) in ACC showed age-related decline. However, no direct relationship was found between CBF and glutamatergic synaptic activity in aging suggesting the age-related alteration in glutamatergic metabolism might not directly affect CBF.-
dc.languageeng-
dc.relation.ispartofISMRM 23rd Annual Meeting and Exhibition 2015-
dc.titleEvaluation of glutamatergic metabolism and its role in neurovascular coupling by combined proton magnetic resonance spectroscopy and pseudo-continuous arterial spin labeling in aging-
dc.typeConference_Paper-
dc.identifier.emailChang, RCC: rccchang@hku.hk-
dc.identifier.emailChu, LW: lwchu@hkucc.hku.hk-
dc.identifier.emailMak, HKF: makkf@hkucc.hku.hk-
dc.identifier.authorityChang, RCC=rp00470-
dc.identifier.authorityMak, HKF=rp00533-
dc.identifier.hkuros255761-

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