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Article: Dynamic 14-3-3/client protein interactions integrate survival and apoptotic pathways

TitleDynamic 14-3-3/client protein interactions integrate survival and apoptotic pathways
Authors
Keywords14-3-3
Apoptosis
Survival signaling
BAD
JNK
Issue Date2006
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/semcancer
Citation
Seminars in Cancer Biology, 2006, v. 16 n. 3, p. 193-202 How to Cite?
AbstractThe serine/threonine binding protein, 14-3-3, possesses a diverse array of client proteins. It is involved in the regulation of apoptosis through multiple interactions with proteins of the core mitochondrial machinery, pro-apoptotic transcription factors, and their upstream signaling pathways. 14-3-3 coordinates with survival kinases to inhibit multiple pro-apoptotic molecules. One prominent mechanism for the suppression of apoptosis is through 14-3-3-mediated sequestration of pro-apoptotic client proteins. On the other hand, cellular stresses appear to signal through the inhibition of 14-3-3 function to exert their pro-apoptotic effect. Global inhibition of 14-3-3/client protein interaction induces apoptosis, and stands as an attractive intervention in diseases involving overactive survival signaling pathways. Because dysregulation of 14-3-3 has been associated with poor survival of cancer patients, targeting 14-3-3 may provide a novel therapeutic approach for the treatment of cancer. © 2006 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/219910
ISSN
2015 Impact Factor: 9.955
2015 SCImago Journal Rankings: 6.320
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorPorter, GW-
dc.contributor.authorKhuri, FR-
dc.contributor.authorFu, H-
dc.date.accessioned2015-09-30T08:43:26Z-
dc.date.available2015-09-30T08:43:26Z-
dc.date.issued2006-
dc.identifier.citationSeminars in Cancer Biology, 2006, v. 16 n. 3, p. 193-202-
dc.identifier.issn1044-579X-
dc.identifier.urihttp://hdl.handle.net/10722/219910-
dc.description.abstractThe serine/threonine binding protein, 14-3-3, possesses a diverse array of client proteins. It is involved in the regulation of apoptosis through multiple interactions with proteins of the core mitochondrial machinery, pro-apoptotic transcription factors, and their upstream signaling pathways. 14-3-3 coordinates with survival kinases to inhibit multiple pro-apoptotic molecules. One prominent mechanism for the suppression of apoptosis is through 14-3-3-mediated sequestration of pro-apoptotic client proteins. On the other hand, cellular stresses appear to signal through the inhibition of 14-3-3 function to exert their pro-apoptotic effect. Global inhibition of 14-3-3/client protein interaction induces apoptosis, and stands as an attractive intervention in diseases involving overactive survival signaling pathways. Because dysregulation of 14-3-3 has been associated with poor survival of cancer patients, targeting 14-3-3 may provide a novel therapeutic approach for the treatment of cancer. © 2006 Elsevier Ltd. All rights reserved.-
dc.languageeng-
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/semcancer-
dc.relation.ispartofSeminars in Cancer Biology-
dc.subject14-3-3-
dc.subjectApoptosis-
dc.subjectSurvival signaling-
dc.subjectBAD-
dc.subjectJNK-
dc.titleDynamic 14-3-3/client protein interactions integrate survival and apoptotic pathways-
dc.typeArticle-
dc.identifier.emailPorter, GW: porterg@hku.hk-
dc.identifier.authorityPorter, GW=rp02099-
dc.identifier.doi10.1016/j.semcancer.2006.03.003-
dc.identifier.pmid16697216-
dc.identifier.scopuseid_2-s2.0-33646903670-
dc.identifier.volume16-
dc.identifier.issue3-
dc.identifier.spage193-
dc.identifier.epage202-
dc.identifier.isiWOS:000238730800005-
dc.publisher.placeUnited Kingdom-

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