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Article: Behavioral effects of deep brain stimulation of different areas of the Papez circuit on memory- and anxiety-related functions

TitleBehavioral effects of deep brain stimulation of different areas of the Papez circuit on memory- and anxiety-related functions
Authors
KeywordsCircuit of Papez
Memory
Hippocampus
Enthorhinal cortex
Deep brain stimulation
Issue Date2015
Citation
Behavioural Brain Research, 2015, v. 292, p. 353-360 How to Cite?
Abstract© 2015 Elsevier B.V. Deep brain stimulation (DBS) has gained interest as a potential therapy for advanced treatment-resistant dementia. However, possible targets for DBS and the optimal stimulation parameters are not yet clear. Here, we compared the effects of DBS of the CA1 sub-region of the hippocampus, mammillothalamic tract, anterior thalamic nucleus, and entorhinal cortex in an experimental rat model of dementia. Rats with scopolamine-induced amnesia were assessed in the object location task with different DBS parameters. Moreover, anxiety-related side effects were evaluated in the elevated zero maze and open field. After sacrifice, we applied c-Fos immunohistochemistry to assess which memory-related regions were affected by DBS. When comparing all structures, DBS of the entorhinal cortex and CA1 sub-region was able to restore memory loss when a specific set of stimulation parameters was used. No anxiety-related side effects were found following DBS. The beneficial behavioral performance of CA1 DBS rats was accompanied with an activation of cells in the anterior cingulate gyrus. Therefore, we conclude that acute CA1 DBS restores memory loss possibly through improved attentional and cognitive processes in the limbic cortex.
Persistent Identifierhttp://hdl.handle.net/10722/219895
ISSN
2015 Impact Factor: 3.002
2015 SCImago Journal Rankings: 1.533

 

DC FieldValueLanguage
dc.contributor.authorHescham, Sarah-
dc.contributor.authorJahanshahi, Ali-
dc.contributor.authorMeriaux, Céline-
dc.contributor.authorLim, Lee Wei-
dc.contributor.authorBlokland, Arjan-
dc.contributor.authorTemel, Yasin-
dc.date.accessioned2015-09-24T04:44:18Z-
dc.date.available2015-09-24T04:44:18Z-
dc.date.issued2015-
dc.identifier.citationBehavioural Brain Research, 2015, v. 292, p. 353-360-
dc.identifier.issn0166-4328-
dc.identifier.urihttp://hdl.handle.net/10722/219895-
dc.description.abstract© 2015 Elsevier B.V. Deep brain stimulation (DBS) has gained interest as a potential therapy for advanced treatment-resistant dementia. However, possible targets for DBS and the optimal stimulation parameters are not yet clear. Here, we compared the effects of DBS of the CA1 sub-region of the hippocampus, mammillothalamic tract, anterior thalamic nucleus, and entorhinal cortex in an experimental rat model of dementia. Rats with scopolamine-induced amnesia were assessed in the object location task with different DBS parameters. Moreover, anxiety-related side effects were evaluated in the elevated zero maze and open field. After sacrifice, we applied c-Fos immunohistochemistry to assess which memory-related regions were affected by DBS. When comparing all structures, DBS of the entorhinal cortex and CA1 sub-region was able to restore memory loss when a specific set of stimulation parameters was used. No anxiety-related side effects were found following DBS. The beneficial behavioral performance of CA1 DBS rats was accompanied with an activation of cells in the anterior cingulate gyrus. Therefore, we conclude that acute CA1 DBS restores memory loss possibly through improved attentional and cognitive processes in the limbic cortex.-
dc.languageeng-
dc.relation.ispartofBehavioural Brain Research-
dc.subjectCircuit of Papez-
dc.subjectMemory-
dc.subjectHippocampus-
dc.subjectEnthorhinal cortex-
dc.subjectDeep brain stimulation-
dc.titleBehavioral effects of deep brain stimulation of different areas of the Papez circuit on memory- and anxiety-related functions-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.bbr.2015.06.032-
dc.identifier.scopuseid_2-s2.0-84936940756-
dc.identifier.hkuros258256-
dc.identifier.volume292-
dc.identifier.spage353-
dc.identifier.epage360-
dc.identifier.eissn1872-7549-

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