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Article: Deep brain stimulation in dementia-related disorders

TitleDeep brain stimulation in dementia-related disorders
Authors
KeywordsFornix
Alzheimer's disease
Deep brain stimulation
Dementia
Papez circuit
Nucleus basalis of Meynert
Neuroanatomy
Memory
Limbic system
Hippocampus
Entorhinal cortex
Issue Date2013
Citation
Neuroscience and Biobehavioral Reviews, 2013, v. 37, n. 10, p. 2666-2675 How to Cite?
AbstractMemory loss is the key symptom of dementia-related disorders, including the prevalent Alzheimer's disease (AD). To date, pharmacological treatments for AD have limited and short-lasting effects. Therefore, researchers are investigating novel therapies such as deep brain stimulation (DBS) to treat memory impairment and to reduce or stop the progression of it. Clinical and preclinical studies have been performed and stimulations of the fornix, entorhinal cortex and nucleus basalis of Meynert have been carried out. The results of these studies suggest that DBS has the potential to enhance memory functions in patients and animal models. The mechanisms underlying memory enhancement may include the release of specific neurotransmitters and neuroplasticity. Some authors suggest that DBS might even be disease-modifying. Nevertheless, it is still premature to conclude that DBS can be used in the treatment of AD, and the field will wait for the results of ongoing clinical trials. © 2013 Elsevier Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/219884
ISSN
2015 Impact Factor: 8.58
2015 SCImago Journal Rankings: 5.290

 

DC FieldValueLanguage
dc.contributor.authorHescham, Sarah-
dc.contributor.authorLim, Lee Wei-
dc.contributor.authorJahanshahi, Ali-
dc.contributor.authorBlokland, Arjan-
dc.contributor.authorTemel, Yasin-
dc.date.accessioned2015-09-24T04:44:15Z-
dc.date.available2015-09-24T04:44:15Z-
dc.date.issued2013-
dc.identifier.citationNeuroscience and Biobehavioral Reviews, 2013, v. 37, n. 10, p. 2666-2675-
dc.identifier.issn0149-7634-
dc.identifier.urihttp://hdl.handle.net/10722/219884-
dc.description.abstractMemory loss is the key symptom of dementia-related disorders, including the prevalent Alzheimer's disease (AD). To date, pharmacological treatments for AD have limited and short-lasting effects. Therefore, researchers are investigating novel therapies such as deep brain stimulation (DBS) to treat memory impairment and to reduce or stop the progression of it. Clinical and preclinical studies have been performed and stimulations of the fornix, entorhinal cortex and nucleus basalis of Meynert have been carried out. The results of these studies suggest that DBS has the potential to enhance memory functions in patients and animal models. The mechanisms underlying memory enhancement may include the release of specific neurotransmitters and neuroplasticity. Some authors suggest that DBS might even be disease-modifying. Nevertheless, it is still premature to conclude that DBS can be used in the treatment of AD, and the field will wait for the results of ongoing clinical trials. © 2013 Elsevier Ltd.-
dc.languageeng-
dc.relation.ispartofNeuroscience and Biobehavioral Reviews-
dc.subjectFornix-
dc.subjectAlzheimer's disease-
dc.subjectDeep brain stimulation-
dc.subjectDementia-
dc.subjectPapez circuit-
dc.subjectNucleus basalis of Meynert-
dc.subjectNeuroanatomy-
dc.subjectMemory-
dc.subjectLimbic system-
dc.subjectHippocampus-
dc.subjectEntorhinal cortex-
dc.titleDeep brain stimulation in dementia-related disorders-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.neubiorev.2013.09.002-
dc.identifier.pmid24060532-
dc.identifier.scopuseid_2-s2.0-84889632158-
dc.identifier.volume37-
dc.identifier.issue10-
dc.identifier.spage2666-
dc.identifier.epage2675-
dc.identifier.eissn1873-7528-

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