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Article: Neurosurgical Treatments of Depression

TitleNeurosurgical Treatments of Depression
Authors
KeywordsTreatment resistant depression
Ablative surgery
Deep brain stimulation
Neurosurgery
Vagal nerve stimulation
Issue Date2013
Citation
Current Topics in Behavioral Neurosciences, 2013, v. 14, p. 327-339 How to Cite?
AbstractThe neurosurgical treatment of treatment-resistant depression (TRD) has entered a new era with more and more patients being treated with deep brain stimulation (DBS) via surgically implanted intracerebral electrodes. Although the mechanisms of action of DBS are still not fully understood, preclinical studies are being conducted to elucidate how the treatment might work. DBS in its present form can be considered as a relatively new neurosurgical treatment for TRD. However, the use of neurosurgery in the management of depression has a much longer history particularly with ablative procedures but also vagal nerve stimulation. Here, we provide a review of the clinical neurosurgical treatments for TRD, with a main emphasis on DBS. In addition, we discuss relevant preclinical data that are revealing new information about DBS mechanisms. © Springer-Verlag Berlin Heidelberg 2012.
Persistent Identifierhttp://hdl.handle.net/10722/219882
ISSN
2015 SCImago Journal Rankings: 1.307

 

DC FieldValueLanguage
dc.contributor.authorTemel, Yasin-
dc.contributor.authorLim, Lee Wei-
dc.date.accessioned2015-09-24T04:44:15Z-
dc.date.available2015-09-24T04:44:15Z-
dc.date.issued2013-
dc.identifier.citationCurrent Topics in Behavioral Neurosciences, 2013, v. 14, p. 327-339-
dc.identifier.issn1866-3370-
dc.identifier.urihttp://hdl.handle.net/10722/219882-
dc.description.abstractThe neurosurgical treatment of treatment-resistant depression (TRD) has entered a new era with more and more patients being treated with deep brain stimulation (DBS) via surgically implanted intracerebral electrodes. Although the mechanisms of action of DBS are still not fully understood, preclinical studies are being conducted to elucidate how the treatment might work. DBS in its present form can be considered as a relatively new neurosurgical treatment for TRD. However, the use of neurosurgery in the management of depression has a much longer history particularly with ablative procedures but also vagal nerve stimulation. Here, we provide a review of the clinical neurosurgical treatments for TRD, with a main emphasis on DBS. In addition, we discuss relevant preclinical data that are revealing new information about DBS mechanisms. © Springer-Verlag Berlin Heidelberg 2012.-
dc.languageeng-
dc.relation.ispartofCurrent Topics in Behavioral Neurosciences-
dc.subjectTreatment resistant depression-
dc.subjectAblative surgery-
dc.subjectDeep brain stimulation-
dc.subjectNeurosurgery-
dc.subjectVagal nerve stimulation-
dc.titleNeurosurgical Treatments of Depression-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1007/7854_2012_222-
dc.identifier.pmid22865464-
dc.identifier.scopuseid_2-s2.0-84880061071-
dc.identifier.volume14-
dc.identifier.spage327-
dc.identifier.epage339-
dc.identifier.eissn1866-3389-

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