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Article: Deactivation of the parvalbumin-positive interneurons in the hippocampus after fear-like behaviour following electrical stimulation of the dorsolateral periaqueductal gray of rats

TitleDeactivation of the parvalbumin-positive interneurons in the hippocampus after fear-like behaviour following electrical stimulation of the dorsolateral periaqueductal gray of rats
Authors
KeywordsHippocampus
Fear
Panic
Parvalbumin
Periaqueductal gray
Issue Date2012
Citation
Behavioural Brain Research, 2012, v. 233, n. 2, p. 322-325 How to Cite?
AbstractThe majority of patients with panic disorder express a fearful sensation when encountered with panic-related cues. A subpopulation of GABAergic interneurons in the hippocampus has been demonstrated in the regulation of behavioural learning, especially during the contextual fear-conditioning. Here, we examined the influence of panic/fear response induced by deep brain stimulation (DBS) of the periaqueductal gray on these hippocampal parvalbumin-positive interneurons. We found that fear-like behaviour did not change the number of c-Fos immunoreactive and parvalbumin-positive cells. However, a remarkable decrease of c-Fos and parvalbumin co-localization was shown in the hippocampal regions when compared to non-stimulated sham animals. In line with previous studies, our results support the hypothesis that GABAergic regulation resulted in enhanced behavioural reactivity to fear conditioning. In conclusion, our findings indicate that the inhibition of this subpopulation of hippocampal parvalbumin-positive interneurons induced a long lasting anxiety- or fear-like behaviour. © 2012 Elsevier B.V.
Persistent Identifierhttp://hdl.handle.net/10722/219878
ISSN
2015 Impact Factor: 3.002
2015 SCImago Journal Rankings: 1.533

 

DC FieldValueLanguage
dc.contributor.authorTemel, Yasin-
dc.contributor.authorBlokland, Arjan-
dc.contributor.authorLim, Lee Wei-
dc.date.accessioned2015-09-24T04:44:14Z-
dc.date.available2015-09-24T04:44:14Z-
dc.date.issued2012-
dc.identifier.citationBehavioural Brain Research, 2012, v. 233, n. 2, p. 322-325-
dc.identifier.issn0166-4328-
dc.identifier.urihttp://hdl.handle.net/10722/219878-
dc.description.abstractThe majority of patients with panic disorder express a fearful sensation when encountered with panic-related cues. A subpopulation of GABAergic interneurons in the hippocampus has been demonstrated in the regulation of behavioural learning, especially during the contextual fear-conditioning. Here, we examined the influence of panic/fear response induced by deep brain stimulation (DBS) of the periaqueductal gray on these hippocampal parvalbumin-positive interneurons. We found that fear-like behaviour did not change the number of c-Fos immunoreactive and parvalbumin-positive cells. However, a remarkable decrease of c-Fos and parvalbumin co-localization was shown in the hippocampal regions when compared to non-stimulated sham animals. In line with previous studies, our results support the hypothesis that GABAergic regulation resulted in enhanced behavioural reactivity to fear conditioning. In conclusion, our findings indicate that the inhibition of this subpopulation of hippocampal parvalbumin-positive interneurons induced a long lasting anxiety- or fear-like behaviour. © 2012 Elsevier B.V.-
dc.languageeng-
dc.relation.ispartofBehavioural Brain Research-
dc.subjectHippocampus-
dc.subjectFear-
dc.subjectPanic-
dc.subjectParvalbumin-
dc.subjectPeriaqueductal gray-
dc.titleDeactivation of the parvalbumin-positive interneurons in the hippocampus after fear-like behaviour following electrical stimulation of the dorsolateral periaqueductal gray of rats-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.bbr.2012.05.029-
dc.identifier.pmid22633919-
dc.identifier.scopuseid_2-s2.0-84862292661-
dc.identifier.volume233-
dc.identifier.issue2-
dc.identifier.spage322-
dc.identifier.epage325-
dc.identifier.eissn1872-7549-

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