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Article: Motor and non-motor behaviour in experimental Huntington's disease

TitleMotor and non-motor behaviour in experimental Huntington's disease
Authors
KeywordsTransgenic rats
Motivation
Huntington's disease
Hypermobility
Anxiety
Food intake
Hedonia
Issue Date2012
Citation
Behavioural Brain Research, 2012, v. 226, n. 2, p. 435-439 How to Cite?
AbstractIn this study, we investigated motor and non-motor behaviour in the transgenic rat model of Huntington's disease (tgHD). In particular, we were interested in the development and changes of motor and non-motor features (anxiety, motivation and hedonia) of disease over time and their interactions. We found tgHD animals to be hyperkinetic in the open field test compared to their wild-type littermates at all ages tested, which was accompanied by reduced anxiety-like behaviour in the open field test and the elevated zero maze, but not in the home cage emergence test. No major changes were found in hedonia (sucrose intake test) and motivation for food (food intake test). Our data suggest that hyperkinetic features and reduced-anxiety in the tgHD rats are associated behaviours and are seen in the earlier stages of the disease. © 2011 Elsevier B.V.
Persistent Identifierhttp://hdl.handle.net/10722/219875
ISSN
2015 Impact Factor: 3.002
2015 SCImago Journal Rankings: 1.533

 

DC FieldValueLanguage
dc.contributor.authorZeef, Dagmar H.-
dc.contributor.authorVlamings, Rinske-
dc.contributor.authorLim, Lee Wei-
dc.contributor.authorTan, Sonny-
dc.contributor.authorJanssen, Marcus L F-
dc.contributor.authorJahanshahi, Ali-
dc.contributor.authorHoogland, Govert-
dc.contributor.authorPrickaerts, Jos-
dc.contributor.authorSteinbusch, Harry W M-
dc.contributor.authorTemel, Yasin-
dc.date.accessioned2015-09-24T04:44:13Z-
dc.date.available2015-09-24T04:44:13Z-
dc.date.issued2012-
dc.identifier.citationBehavioural Brain Research, 2012, v. 226, n. 2, p. 435-439-
dc.identifier.issn0166-4328-
dc.identifier.urihttp://hdl.handle.net/10722/219875-
dc.description.abstractIn this study, we investigated motor and non-motor behaviour in the transgenic rat model of Huntington's disease (tgHD). In particular, we were interested in the development and changes of motor and non-motor features (anxiety, motivation and hedonia) of disease over time and their interactions. We found tgHD animals to be hyperkinetic in the open field test compared to their wild-type littermates at all ages tested, which was accompanied by reduced anxiety-like behaviour in the open field test and the elevated zero maze, but not in the home cage emergence test. No major changes were found in hedonia (sucrose intake test) and motivation for food (food intake test). Our data suggest that hyperkinetic features and reduced-anxiety in the tgHD rats are associated behaviours and are seen in the earlier stages of the disease. © 2011 Elsevier B.V.-
dc.languageeng-
dc.relation.ispartofBehavioural Brain Research-
dc.subjectTransgenic rats-
dc.subjectMotivation-
dc.subjectHuntington's disease-
dc.subjectHypermobility-
dc.subjectAnxiety-
dc.subjectFood intake-
dc.subjectHedonia-
dc.titleMotor and non-motor behaviour in experimental Huntington's disease-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.bbr.2011.09.041-
dc.identifier.pmid22001615-
dc.identifier.scopuseid_2-s2.0-81355148484-
dc.identifier.volume226-
dc.identifier.issue2-
dc.identifier.spage435-
dc.identifier.epage439-
dc.identifier.eissn1872-7549-

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