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Article: Attenuation of fear-like response by escitalopram treatment after electrical stimulation of the midbrain dorsolateral periaqueductal gray

TitleAttenuation of fear-like response by escitalopram treatment after electrical stimulation of the midbrain dorsolateral periaqueductal gray
Authors
KeywordsAgoraphobia
Electrical stimulation
Panic disorder
Anticipatory anxiety
Periaqueductal gray
Issue Date2010
Citation
Experimental Neurology, 2010, v. 226, n. 2, p. 293-300 How to Cite?
AbstractElectrical stimulation of the dorsolateral periaqueductal gray (dlPAG) has frequently been shown to induce escape and freezing/decreased locomotion responses which mimic panic- and fear-like behaviour. In the present study we tested whether such spontaneous fear-like behaviour could be observed in an open-field test 12. h after dlPAG stimulation. Further, we tested whether this fear-like behaviour could be attenuated by acute or chronic administration of buspirone and escitalopram. Our data demonstrate for the first time that animals showed fear-like behaviour 12. h after dlPAG stimulation, which may possibly reflect panic disorder with anticipatory anxiety/agoraphobic symptoms. Acute and chronic escitalopram, but not buspirone, treatment attenuated the fear-related behaviour. Besides, our data also showed that the stimulation intensities to evoke an escape reaction, a panicogenic response, were significantly higher after chronic buspirone and escitalopram treatment. These results suggest that the fear-like response, which was observed 12. h after dlPAG stimulation, could be considered as a relevant animal model for panic disorder with anticipatory anxiety/agoraphobic symptoms. © 2010 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/219865
ISSN
2015 Impact Factor: 4.657
2015 SCImago Journal Rankings: 2.427

 

DC FieldValueLanguage
dc.contributor.authorLim, Lee Wei-
dc.contributor.authorBlokland, Arjan-
dc.contributor.authorTan, Sonny-
dc.contributor.authorVlamings, Rinske-
dc.contributor.authorSesia, Thibaut-
dc.contributor.authorAziz-Mohammadi, Mujzgan-
dc.contributor.authorVisser-Vandewalle, Veerle-
dc.contributor.authorSteinbusch, Harry W M-
dc.contributor.authorSchruers, Koen-
dc.contributor.authorTemel, Yasin-
dc.date.accessioned2015-09-24T04:44:10Z-
dc.date.available2015-09-24T04:44:10Z-
dc.date.issued2010-
dc.identifier.citationExperimental Neurology, 2010, v. 226, n. 2, p. 293-300-
dc.identifier.issn0014-4886-
dc.identifier.urihttp://hdl.handle.net/10722/219865-
dc.description.abstractElectrical stimulation of the dorsolateral periaqueductal gray (dlPAG) has frequently been shown to induce escape and freezing/decreased locomotion responses which mimic panic- and fear-like behaviour. In the present study we tested whether such spontaneous fear-like behaviour could be observed in an open-field test 12. h after dlPAG stimulation. Further, we tested whether this fear-like behaviour could be attenuated by acute or chronic administration of buspirone and escitalopram. Our data demonstrate for the first time that animals showed fear-like behaviour 12. h after dlPAG stimulation, which may possibly reflect panic disorder with anticipatory anxiety/agoraphobic symptoms. Acute and chronic escitalopram, but not buspirone, treatment attenuated the fear-related behaviour. Besides, our data also showed that the stimulation intensities to evoke an escape reaction, a panicogenic response, were significantly higher after chronic buspirone and escitalopram treatment. These results suggest that the fear-like response, which was observed 12. h after dlPAG stimulation, could be considered as a relevant animal model for panic disorder with anticipatory anxiety/agoraphobic symptoms. © 2010 Elsevier Inc.-
dc.languageeng-
dc.relation.ispartofExperimental Neurology-
dc.subjectAgoraphobia-
dc.subjectElectrical stimulation-
dc.subjectPanic disorder-
dc.subjectAnticipatory anxiety-
dc.subjectPeriaqueductal gray-
dc.titleAttenuation of fear-like response by escitalopram treatment after electrical stimulation of the midbrain dorsolateral periaqueductal gray-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.expneurol.2010.08.035-
dc.identifier.pmid20837005-
dc.identifier.scopuseid_2-s2.0-77958493029-
dc.identifier.volume226-
dc.identifier.issue2-
dc.identifier.spage293-
dc.identifier.epage300-
dc.identifier.eissn1090-2430-

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