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Article: Fos immunoreactivity in the rat forebrain induced by electrical stimulation of the dorsolateral periaqueductal gray matter

TitleFos immunoreactivity in the rat forebrain induced by electrical stimulation of the dorsolateral periaqueductal gray matter
Authors
KeywordsForebrain
Escape behaviour
c-Fos immunoreactivity
Periaqueductal gray
Panic-like behaviour
Neuroanatomy
Fear-like behaviour
Issue Date2009
Citation
Journal of Chemical Neuroanatomy, 2009, v. 38, n. 2, p. 83-96 How to Cite?
AbstractElectrical stimulation of the dorsolateral periaqueductal gray (dlPAG) matter induces panic- or fear-like responses with intense emotional distress and severe anxiety. In this study, we evoked panic-like behaviour by dlPAG stimulation and evaluated the effect on neuronal activation in different brain regions. The number of c-Fos immunoreactive (c-Fos-ir) cells was measured semi-quantitatively through series of stained rat brain sections. Our results demonstrate strong neural activation in the medial prefrontal cortex, orbital cortex, anterior olfactory nuclei, secondary motor cortex, and the somatosensory cortex. Moderate increases in the number of c-Fos-ir cells were detected in various regions, including the hypothalamus, amygdala, and striatum. Additionally, there was mild expression of c-Fos-ir cells in the hippocampus, thalamus, and habenula regions. In conclusion, we have shown that deep brain stimulation of the dlPAG produced a distinctive pattern of neuronal activation across forebrain regions as compared to the sham and control animals. © 2009 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/219858
ISSN
2015 Impact Factor: 1.8
2015 SCImago Journal Rankings: 0.908

 

DC FieldValueLanguage
dc.contributor.authorLim, Lee Wei-
dc.contributor.authorTemel, Yasin-
dc.contributor.authorVisser-Vandewalle, Veerle-
dc.contributor.authorBlokland, Arjan-
dc.contributor.authorSteinbusch, Harry-
dc.date.accessioned2015-09-24T04:44:08Z-
dc.date.available2015-09-24T04:44:08Z-
dc.date.issued2009-
dc.identifier.citationJournal of Chemical Neuroanatomy, 2009, v. 38, n. 2, p. 83-96-
dc.identifier.issn0891-0618-
dc.identifier.urihttp://hdl.handle.net/10722/219858-
dc.description.abstractElectrical stimulation of the dorsolateral periaqueductal gray (dlPAG) matter induces panic- or fear-like responses with intense emotional distress and severe anxiety. In this study, we evoked panic-like behaviour by dlPAG stimulation and evaluated the effect on neuronal activation in different brain regions. The number of c-Fos immunoreactive (c-Fos-ir) cells was measured semi-quantitatively through series of stained rat brain sections. Our results demonstrate strong neural activation in the medial prefrontal cortex, orbital cortex, anterior olfactory nuclei, secondary motor cortex, and the somatosensory cortex. Moderate increases in the number of c-Fos-ir cells were detected in various regions, including the hypothalamus, amygdala, and striatum. Additionally, there was mild expression of c-Fos-ir cells in the hippocampus, thalamus, and habenula regions. In conclusion, we have shown that deep brain stimulation of the dlPAG produced a distinctive pattern of neuronal activation across forebrain regions as compared to the sham and control animals. © 2009 Elsevier B.V. All rights reserved.-
dc.languageeng-
dc.relation.ispartofJournal of Chemical Neuroanatomy-
dc.subjectForebrain-
dc.subjectEscape behaviour-
dc.subjectc-Fos immunoreactivity-
dc.subjectPeriaqueductal gray-
dc.subjectPanic-like behaviour-
dc.subjectNeuroanatomy-
dc.subjectFear-like behaviour-
dc.titleFos immunoreactivity in the rat forebrain induced by electrical stimulation of the dorsolateral periaqueductal gray matter-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jchemneu.2009.06.011-
dc.identifier.pmid19589381-
dc.identifier.scopuseid_2-s2.0-68349155698-
dc.identifier.volume38-
dc.identifier.issue2-
dc.identifier.spage83-
dc.identifier.epage96-

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