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Article: Complexes with the fac-{M(CO)3}+ (M = 99mTc, Re) moiety and long alkyl chain ligands as Lipiodol surrogates

TitleComplexes with the fac-{M(CO)3}+ (M = 99mTc, Re) moiety and long alkyl chain ligands as Lipiodol surrogates
Authors
KeywordsBioorganometallic
Lipiodol
Liver cancer
Technetium complexes
Fatty acid
Labelling
Issue Date2006
Citation
Inorganica Chimica Acta, 2006, v. 359, n. 12, p. 4087-4094 How to Cite?
AbstractAccumulation of radiopharmaceuticals in the liver is frequently observed and represents in general a limiting factor when developing novel labeled compounds for any purpose in nuclear medicine. Aiming at the treatment of liver cancer with radiopharmaceuticals, such accumulation is desired but the compounds have to remain in the liver over an extended time period rather than being washed out or redistributed over time in the whole body. Lipiodol is known to remain in the liver and we present here a study for the preparation of 186Re and 99mTc labeled Lipiodol surrogates expected to behave similarly. We have synthesized two bidentate and two tridentate ligands conjugated to a pendant C18 chain as well as their corresponding fac-[Re(CO)3]+ and fac-[Tc(CO)3]+ complexes. Three of the rhenium complexes have been structurally characterized. Labelling with [186Re(OH2)3(CO)3] + and [99mTc(OH2)3(CO)3] +, respectively, gave yields in the range of 90%. The complexes could be extracted into Lipiodol due to their high lipophilicity and close structural relationship with the major components of Lipiodol. The complexes are stable in water and in Lipiodol for more than 24 h. These Lipiodol surrogates present new low-valent technetium and rhenium complexes for applications in liver cancer imaging and therapy. © 2006 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/219513
ISSN
2015 Impact Factor: 1.918
2015 SCImago Journal Rankings: 0.584

 

DC FieldValueLanguage
dc.contributor.authorSaw, Maung M.-
dc.contributor.authorKurz, Philipp-
dc.contributor.authorAgorastos, Nikos-
dc.contributor.authorHor, T. S Andy-
dc.contributor.authorSundram, Felix X.-
dc.contributor.authorYan, Yaw Kai-
dc.contributor.authorAlberto, Roger-
dc.date.accessioned2015-09-23T02:57:16Z-
dc.date.available2015-09-23T02:57:16Z-
dc.date.issued2006-
dc.identifier.citationInorganica Chimica Acta, 2006, v. 359, n. 12, p. 4087-4094-
dc.identifier.issn0020-1693-
dc.identifier.urihttp://hdl.handle.net/10722/219513-
dc.description.abstractAccumulation of radiopharmaceuticals in the liver is frequently observed and represents in general a limiting factor when developing novel labeled compounds for any purpose in nuclear medicine. Aiming at the treatment of liver cancer with radiopharmaceuticals, such accumulation is desired but the compounds have to remain in the liver over an extended time period rather than being washed out or redistributed over time in the whole body. Lipiodol is known to remain in the liver and we present here a study for the preparation of 186Re and 99mTc labeled Lipiodol surrogates expected to behave similarly. We have synthesized two bidentate and two tridentate ligands conjugated to a pendant C18 chain as well as their corresponding fac-[Re(CO)3]+ and fac-[Tc(CO)3]+ complexes. Three of the rhenium complexes have been structurally characterized. Labelling with [186Re(OH2)3(CO)3] + and [99mTc(OH2)3(CO)3] +, respectively, gave yields in the range of 90%. The complexes could be extracted into Lipiodol due to their high lipophilicity and close structural relationship with the major components of Lipiodol. The complexes are stable in water and in Lipiodol for more than 24 h. These Lipiodol surrogates present new low-valent technetium and rhenium complexes for applications in liver cancer imaging and therapy. © 2006 Elsevier B.V. All rights reserved.-
dc.languageeng-
dc.relation.ispartofInorganica Chimica Acta-
dc.subjectBioorganometallic-
dc.subjectLipiodol-
dc.subjectLiver cancer-
dc.subjectTechnetium complexes-
dc.subjectFatty acid-
dc.subjectLabelling-
dc.titleComplexes with the fac-{M(CO)3}+ (M = 99mTc, Re) moiety and long alkyl chain ligands as Lipiodol surrogates-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ica.2006.04.023-
dc.identifier.scopuseid_2-s2.0-33746584401-
dc.identifier.volume359-
dc.identifier.issue12-
dc.identifier.spage4087-
dc.identifier.epage4094-

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